Imprecision Investigation and Analysis of Routine Chemistry in China

Abstract

There is huge space for us to enhance and substantial effort is needed in improving and implementing quality management in China.

Status of internal quality control for thyroid hormones immunoassays from 2011 to 2016 in China

“…Actually, the calculation of current CVs was performed according to all in‐control results judged by laboratories’ own IQC control rules in February of each year. But to calculate the cumulative CVs, laboratories need to collect all in‐control results from the first day on which the same lot of control material was used to the last day until February . Due to the different collecting time among all laboratories, this study only analyze current CVs to ensure the comparability of data.…”

“…Internal quality control (IQC), as an effective tool to discover detection errors in the analytical phase, plays a key role in improving precision level of clinical laboratories . Through collecting 2011‐2016 IQC results in the national External Quality Assessment (EQA) programs and assessing percentages of laboratories meeting five different performance specifications of precision, this study was to make a conclusion for FT3, TT3, FT4, TT4, and TSH whether the IQC practice had changed and whether the precision performance of Chinese clinical laboratories had made great progress, also help laboratories select the most appropriate allowable imprecision specification and raise precision level.…”

Evaluation of Sigma value and quality goal index for brain natriuretic peptide test

“…The percentage CV for monitoring the imprecision of measurements reflects the quality of the laboratory analysis phase [22]. In a study of 72 laboratories in China, the findings showed that using the Siemens BNP kits, the median CV ranged from 4.87% (interquartile range [IQR] 2.38) to 5.17% (IQR 3.33) [23].…”

Internal quality control status for BNP and NT‐proBNP in China from 2014 to 2017

“…To calculate current CVs, laboratories have to collect all in‐control results judged by their own quality control rules in April yearly. But the calculation of cumulative CVs is based on all in‐control results from the first day on which the same lot of control materials is used to the last day until April . Considering the difference in collecting time among various laboratories, this study only used current CVs to make sure the data could be compared and analyzed.…”

“…The coefficient of variation (CV) is an indicator that describes the degree of data variation and is calculated as the standard deviation divided by the mean value multiplied by 100. Derived from IQC data, CV can be used to monitor the imprecision of measurement and reflect the quality of laboratory analysis phase . Therefore, laboratories can evaluate and control the imprecision level of BNP and NT‐proBNP by monitoring CVs and performing appropriate IQC programs.…”