Impregnation of a biocompatible polymer aided by supercritical CO2: Evaluation of drug stability and drug–matrix interactions

Drug loading of polymer implants by supercritical CO 2 assisted impregnation: A review

“…Thanks to UV-vis or infrared or Raman analysis, the establishment of hydrogen bonding between polymers and drugs have been referred in many systems such as {chitosan + quercetin}, {PMMA + ibuprofen}, {PMMA + triflusal}, {PVP + ketoprofen}, {acrylic based hydrogel + flurbiprofen}, {acrylic based hydrogel + norfloxacin}, {P(D,L)LA + indomethacin}, and {PLGA + indomethacin}[24,33,34,[39][40][41]49,52,58].…”

Solid-state radical grafting reaction of glycidyl methacrylate and poly(4-methyl-1-pentene) in supercritical carbon dioxide: Surface morphology and adhesion

“…Supercritical CO 2 (scCO 2 ) impregnation technology could be an attractive reaction strategy to make graft polymers of high quality and good macromolecular stability, thus minimizing the risk of degradation. The use of scCO 2 as an impregnating agent for organic molecules has been widely reported [23][24][25]. An important advantage of scCO 2 technology for impregnation of polymers is that it can be viewed as a green chemistry alternative due to the absence of potentially toxic solvents or any other impurities, and there is still the possibility of recycling gas by its reintroduction into new process [26][27][28].…”

Supercritical carbon dioxide in organometallic synthesis: Combination of sc-CO2 with Nafion film as a novel reagent in the synthesis of ethers from hydroxymethylmetallocenes

“…Supercritical carbon dioxide, sc-CO 2 , one of the most usable supercritical fluids, is capable of dissolving many organic and organometallic compounds and introducing them into porous materials and also through sorption procedure into nonporous substances that founds an application for the modification of polymers [1][2][3][4]. Application of the supercritical carbon dioxide in organometallic chemistry, mostly as a reaction medium, has been pioneered by Polyakoff and co-workers [5].…”