Impression Smear of Liver Tissue from a Rabbit

Al-Rukibat, Raida K.; Irizarry, Armando R.; Lacey, Janice K.; Kazacos, Kevin R.; Storandt, Scott T.; DeNicola, Dennis B.

doi:10.1111/j.1939-165x.2001.tb00259.x

Cited by 14 publications

(10 citation statements)

References 6 publications

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“…In agreement with Al-Naimi [22], jaundice was only seen in very severe cases. The liver impression smears of hepatic coccidiosis described in this study were as described in other works [3, 33]. Our study demonstrated the superior efficacy of curative use of diclazuril and sulphachloropyrazine against rabbit coccidiosis.…”

Section: Discussionsupporting

confidence: 83%

Efficacy of Sulphachloropyrazine, Amprolium Hydrochloride, Trimethoprim-Sulphamethoxazole, and Diclazuril against Experimental and Natural Rabbit Coccidiosis

Ogolla

Gathumbi

Waruiru

et al. 2018

Journal of Veterinary Medicine

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There are no anticoccidial drugs labelled for rabbits in Kenya and those available are used as extra labels from poultry. The drugs are used in rabbits with limited knowledge of their efficacy and safety. The aim of this study was to determine the efficacy of sulphachloropyrazine, amprolium hydrochloride, and trimethoprim-sulphamethoxazole relative to diclazuril when used curatively against experimental and natural rabbit coccidiosis. In a controlled laboratory trial, sixty (60) rabbits were randomly allocated to six treatment groups, namely, 1A, 2B, 3C, 4D, 5E, and 6F, each with 10 rabbits. Groups 2B, 3C, 4D, 5E, and 6F were experimentally infected with mixed Eimeria species while group 1A served as uninfected-untreated (negative) control group. Four of the infected groups were treated with sulphachloropyrazine (5E), amprolium hydrochloride (2B), trimethoprim-sulphamethoxazole (6F), and diclazuril (4D) using dosages recommended by manufacturers. Group 3C served as infected-untreated (positive) control. A field efficacy trial in naturally infected rabbits was then undertaken. The results revealed that sulphachloropyrazine and diclazuril were effective against rabbit clinical coccidiosis by significantly reducing oocyst counts from 149.00±110.39 x 104 to 3.31±0.86 x 104 Eimeria spp. oocysts per gram of feces (opg) and 59.70±12.35 x 104 to 0.0±0.0 x 104 opg, respectively, in the laboratory trial. Similarly, sulphachloropyrazine and diclazuril recorded reduced oocyst counts in the field trial from 280.33±44.67 x 103 to 0.44±0.14 x 103 opg and 473.44±176.01 x 103 to 0.0±0.0 x 103 opg, respectively. Still, sulphachloropyrazine and diclazuril showed superior efficacy by registering lesion scores and fecal scores close to those of uninfected untreated control group. Trimethoprim-sulphamethoxazole recorded a satisfactory efficacy in the field trial by recording reduced oocyst counts from 266.78±37.03 x 103 to 0.75±0.11 x 103 opg but was not efficacious in the laboratory trial. Amprolium hydrochloride was not efficacious against clinical coccidiosis in both the experimental and field trials.

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Section: Discussionsupporting

confidence: 83%

Efficacy of Sulphachloropyrazine, Amprolium Hydrochloride, Trimethoprim-Sulphamethoxazole, and Diclazuril against Experimental and Natural Rabbit Coccidiosis

Ogolla

Gathumbi

Waruiru

et al. 2018

Journal of Veterinary Medicine

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“…In respect to the absence of E. stiedae in the present investigation, similar observation was reported previously in USA, France and Saudi Arabia, respectively (Al-Mathal 2008;Al-Rukibat et al 2001;Gres et al 2003).…”

Section: Discussionsupporting

confidence: 78%

An Epidemiological Study on Endoparasites of Domestic Rabbits (Oryctolagus cuniculus) in Egypt with Special Reference to Their Health Impact

Elshahawy¹,

El-Goniemy²

2018

JSM

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“…Kids are most susceptible; however, infected adults become carriers. There are 2 anatomical forms: hepatic caused by Eimeria stiedae (2), and intestinal caused by E. magna, E. irresidue, E. media, E. perforans, E. flavescens, E. intestinalis or other Eimeria species, transmission of both the hepatic and intestinal forms is by ingestion of sporulated oocysts usually in contaminated feed or water (3,4).The oocysts of Eimeria steidae were first seen by Antoni Van-Leewenhoek in the bile of a rabbit in 1674 (5). The disease is a ubiquitous protozoan infection of animals seriously impairing their growth and food utelization (6).…”

Section: Introductionmentioning

confidence: 99%

Pathological study of Hepatic coccidiosis in naturally infected rabbits

Naimi

Khalaf²,

Tano³

et al. 2012

QJVMS

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Thirty young domesticated rabbits (age 2-2.5 mo) of sexes showed clinical signs of anorexia, debilitation, diarrhea, icterus, rough hair coat and pendulous abdomen with hepatomegaly. Fecal samples were collected for demonstrated the presence of oocyts. Postmortem examination revealed presence of discrete yellowish-white nodules of 1mm to 2 cm size on the surface and throughout the parenchyma containing a thick creamy white fluid. The histopathological changes showed biliary hyperplasia with different developmental stages of Eimeria stiedae in the epithelial cells, cholangitis and peribiliary fibrosis with newly formed bile ductules, severe congestion and dilation of central veins and sinusoids with disruption hemorrhagic areas. The hepatocytes showed degenerative changes to necrosis with areas of fibrosis and mononuclear cell aggregation, obstructive jaundice and a tendency to form oocyst granuloma. In conclusion hepatic coccidiosis lead to severe pathological changes both in bile ducts and liver parenchyma especially in young animals.

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Impression Smear of Liver Tissue from a Rabbit

Cited by 14 publications

References 6 publications

Efficacy of Sulphachloropyrazine, Amprolium Hydrochloride, Trimethoprim-Sulphamethoxazole, and Diclazuril against Experimental and Natural Rabbit Coccidiosis

Efficacy of Sulphachloropyrazine, Amprolium Hydrochloride, Trimethoprim-Sulphamethoxazole, and Diclazuril against Experimental and Natural Rabbit Coccidiosis

An Epidemiological Study on Endoparasites of Domestic Rabbits (Oryctolagus cuniculus) in Egypt with Special Reference to Their Health Impact

Pathological study of Hepatic coccidiosis in naturally infected rabbits

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