Imprint cytologic features of pulmonary large cell neuroendocrine carcinoma: Comparison with classic large cell carcinoma

Iyoda, Akira; Baba, Masayuki; Hiroshima, Kenzo; Saitoh, Hideo; Moriya, Yasumitsu; Shibuya, Kiyoshi; Iwamoto, Toshihiko; Horiuchi, Fumio; Ohwada, Hayato; Fujisawa, Takehiko

doi:10.3892/or.11.2.285

Cited by 11 publications

(9 citation statements)

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“…In contrast, classic large cell carcinomas show bizarre cells with inflammatory cell infiltration. The morphometry analysis showed significantly different tumor cell sizes between LCNEC and classic large cell carcinoma 12 . Our case is compatible with the criteria of LCNEC.…”

Section: Discussionsupporting

confidence: 86%

Roentgenological occult large-cell neuroendocrine carcinoma: Report of a long-term survivor

Kamiyoshihara

Igarashi

Igai

et al. 2013

Respiratory Medicine Case Reports

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A 64-year-old male patient complained of a one-month history of bloody sputum. A polypoid tumor was almost obstructing the orifice of the subsegmental bronchus (B8b) of the anterior basal segment of the right lower lobe on bronchoscopy. Biopsy specimens of the tumor surface yielded a diagnosis of undifferentiated carcinoma. Clinical staging was T1aN0M0, stage IA. Surgical resection that comprised a right upper lobectomy with systematic mediastinal and hilar lymph node dissection was performed. Histopathologically, the tumor specimen was compatible with large-cell neuroendocrine carcinoma (LCNEC) of the subsegmental bronchus. Pathological staging was T1aN0M0, stage IA. To our knowledge, few cases of central-type LCNEC have been reported in the English literature, and ours is the first report of roentgenological occult LCNEC.

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Section: Discussionsupporting

confidence: 86%

Roentgenological occult large-cell neuroendocrine carcinoma: Report of a long-term survivor

Kamiyoshihara

Igarashi

Igai

et al. 2013

Respiratory Medicine Case Reports

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“…The WHO classification of tumors of the lungs indicates that large cell neuroendocrine carcinomas show histologic features such as organoid nesting, trabecular growth, and palisaded patterns with the tumor cells generally being large in size and having moderate to abundant cytoplasm with nucleoli being present [ 10 ]. Characteristic cellular features of large cell neuroendocrine carcinoma of the lungs have also been described in needle aspiration and imprint cytology studies with emphases placed on nuclear size, nuclear/cytoplasmic ratios, and perceptibility of nucleoli in tumor cells [ 11 – 13 ]. Touch preparations were made during the time of the intraoperative consultation in this case.…”

Section: Discussionmentioning

confidence: 99%

High Grade (Large Cell) Neuroendocrine Carcinoma of the Nasopharynx: Novel Case Report with Touch Preparation Cytology and Positive EBV Encoded Early RNA

Sturgis

Burkey

Momin

et al. 2015

Case Reports in Pathology

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Fewer than five case reports of primary large cell neuroendocrine carcinoma of the nasopharynx are known to the authors. No previous reports have included examples of cytomorphology or have proven association with Epstein-Barr virus. We herein illustrate MRI findings, histopathologic features, immunohistochemical characterization, cytologic details, and in situ hybridization studies from a unique case of primary large cell neuroendocrine carcinoma of the nasopharynx in a 38-year-old Caucasian male patient. Recognition of rare tumor types of the nasopharynx allows for refinements in disease management and prognostication.

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“…Although unique cytologic characteristics have been identified, immunohistochemical staining concentrating on neuroendocrine features and the evaluation of mitotic rate from histological sections are vital to a correct diagnosis [23][24][25][26][27]. Thus it is very difficult to diagnose patients preoperatively with small biopsy specimens [13].…”

Section: Diagnosismentioning

confidence: 99%

Large cell/neuroendocrine carcinoma

Gollard¹,

Jhatakia²,

Elliott³

et al. 2010

Lung Cancer

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Imprint cytologic features of pulmonary large cell neuroendocrine carcinoma: Comparison with classic large cell carcinoma

Cited by 11 publications

References 0 publications

Roentgenological occult large-cell neuroendocrine carcinoma: Report of a long-term survivor

Roentgenological occult large-cell neuroendocrine carcinoma: Report of a long-term survivor

High Grade (Large Cell) Neuroendocrine Carcinoma of the Nasopharynx: Novel Case Report with Touch Preparation Cytology and Positive EBV Encoded Early RNA

Large cell/neuroendocrine carcinoma

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