Imprint cytology of osteosarcoma of the jaw: a case report

Cabral, Luiz Antônio Guimarães; Werkman, Cristina; Brandão, Adriana Aigotti Haberbeck; Almeida, Janete Días

doi:10.1186/1752-1947-3-9327

Cited by 14 publications

(9 citation statements)

References 14 publications

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“…The estimated incidence of OS is 4-5 per million in the population (Hori et al, 2010). OS is characterized by the proliferation of neoplastic cells directly from bone or osteoid tissue (Cabral et al, 2009). For the 40% of patients that develop disease progression of OS, after first line therapy, further treatment with additional chemotherapy is palliative and toxic (Dean et al, 2005).…”

Section: Introductionmentioning

confidence: 99%

Bisphosphonate enhances TRAIL sensitivity to human osteosarcoma cellsviadeath receptor 5 upregulation

et al. 2011

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Tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL), a member of the TNF superfamily of cytokines, is one of the most promising candidates for cancer therapeutics. However, many osteosarcomas are resistant to TRAIL. Bisphosphonates are very effective in the treatment of bone problems associated with malignancies; the antitumor effects are due to the inhibition of protein prenylation that is essential for cell function and survival. The purpose of this study was to determine the effects of bisphosphonates on TRAIL-resistant MG 63 human osteosarcoma cells. The cells showed no response to TRAIL alone; however, pre-treatment with bisphosphonates significantly increased TRAIL-mediated apoptosis and cellular activation of caspase-3. Bisphosphonates significantly induced mRNA and protein expression of the TRAIL receptor, DR5. Bisphosphonates induced protein unprenylation in MG 63 cells; in addition, co-treatment with TRAIL also significantly increased protein unprenylation. Blocking of protein unprenylation using geranylgeraniol attenuated the cellular responses, including cell apoptosis and protein unprenylation induced by bisphosphonates and TRAIL. This is the first study to demonstrate that bisphosphonates markedly enhanced TRAIL-induced apoptosis in human osteosarcoma cells. These findings suggest that bisphosphonates may be a new and effective anticancer treatment with TRAIL proteins for TRAIL-resistant cancer cells.

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Section: Introductionmentioning

confidence: 99%

Bisphosphonate enhances TRAIL sensitivity to human osteosarcoma cellsviadeath receptor 5 upregulation

et al. 2011

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“…A CT scan of an osteosarcoma often shows formation of irregular endosteal and extracortical bone as well as a destroyed or obliterated cortex. However, CT scan cannot differentiate between osteosarcoma and fibrous dysplasia, a typical sunray spiculations were seen in the soft tissue in this case which were highly suggestive of osteosarcoma (7). A tissue biopsy is the only means of making a definitive diagnosis and such cases presenting clinically of osteosarcoma requires a biopsy as soon as possible as done in our case.…”

Section: Discussionmentioning

confidence: 98%

“…A tissue biopsy is the only means of making a definitive diagnosis and such cases presenting clinically of osteosarcoma requires a biopsy as soon as possible as done in our case. The deep biopsy specimen should be taken from the centre of the lesion (1,7). This will avoid missing the diagnostic portion of the tumor because the superficial specimen will perhaps include the immature part of the lesion (1).…”

Section: Discussionmentioning

confidence: 99%

Osteosarcoma of maxilla: A case report

Sheikh¹,

Pallagatti²,

Aggarwal³

et al. 2010

J Clin Exp Dent

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Osteosarcoma is a common primary malignant bone tumor producing osteoid or bone. It occurs very infrequently in the jaws and comprises of 4% of the tumour number as compared to the osteosarcoma of the long bones. Osteosarcoma of the maxilla is even rarer presenting with common clinical features of pain and swelling. This presented case is a rare case of osteosarcoma of maxilla in a 21-year-old female patient. Diagnosis and pre-operative assessment was performed using a combination of intraoral periapical radiograph, occlusal radiograph, paranasal view and computed tomography (CT). CT revealed destruction of the walls of maxillary sinus and sunray type of ossification in the soft tissues. Conformation was done with histology report followed by surgical removal of the tumor with safety margins. Dental professionals may be the first to detect jaw osteosarcomas in their initial stages. Regardless of the favourable biological behaviour, the patients of jaw osteosarcoma usually exhibit advanced tumor as it often goes unnoticed by the dental professional thus stressing on the need for early diagnosis of the lesion. The aim of this case report is to draw attention to the possibility of diagnosing this tumor based on clinical and radiographical characteristics before confirmation by histology.

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“…In some cases, there should be widening of the periodontal ligament space also known as Garrington sign [10]. A plain radiograph usually demonstrates a destructive mass associated to irregular, spiculated periosteal reaction [11]. An integrative CT scan confirms irregular mass with periosteal and endosteal reaction even if osteosarcoma and fibrous dysplasia have a similar presentation even if as "sunray spiculations" in soft tissue could indicate osteosarcoma.…”

Section: Discussionmentioning

confidence: 99%

Local invasion of jaw osteosarcoma

Fiori¹,

Vivo²,

Scarano³

et al. 2015

IJCRI

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International Journal of Case Reports and Images (IJCRI) is an international, peer reviewed, monthly, open access, online journal, publishing high-quality, articles in all areas of basic medical sciences and clinical specialties.Aim of IJCRI is to encourage the publication of new information by providing a platform for reporting of unique, unusual and rare cases which enhance understanding of disease process, its diagnosis, management and clinico-pathologic correlations. One of the most common primary malignant bone tumor is osteosarcoma that counts high percentages in the level of incidence the 5% of all tumor in children, and the 9% of all sarcomas. Osteosarcoma are malignant bone tumors developing from mesenchymal tumor cells that growth as disorganized immature bone or osteoid tissue. Patients affected by osteosarcoma show a peak incidence related to puberty (for young female 12±2 years and for young male 16±1.8 years). Regardless of the favorable biological behaviour, the patients of jaw osteosarcoma usually exhibit advanced tumor as it often goes unnoticed by the dental professional thus stressing on the need for early diagnosis of the lesion. Case Report: We report an unusual case history of a 34-year-old male with swelling and blood loss in anterior gingival of maxilla with loss of teeth. Conclusion:There are three main methods to diagnose the tumor based on clinical and radiographic characteristics before confirmation by histology and to bring attention to dental professional to approach cases diagnosing them at an early stage leading to better prognosis.

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Imprint cytology of osteosarcoma of the jaw: a case report

Cited by 14 publications

References 14 publications

Bisphosphonate enhances TRAIL sensitivity to human osteosarcoma cellsviadeath receptor 5 upregulation

Bisphosphonate enhances TRAIL sensitivity to human osteosarcoma cellsviadeath receptor 5 upregulation

Osteosarcoma of maxilla: A case report

Local invasion of jaw osteosarcoma

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