Imprint Cytology of Sentinel Lymph Nodes in Breast Cancer

Sauer, Torill; Engh, Vibeke; Holck, Anne Marie; Sørpebøl, Grete; Heim, Mette; Furu, Irene; Schlichting, Ellen

doi:10.1159/000326603

Cited by 24 publications

(2 citation statements)

References 27 publications

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“…Another specific disadvantage of FS is that in case of a small-sized SLN the possibility of tissue destruction with parallel absence of material for final histological examination is apparent. Therefore, FS cannot be performed on occasion because of inadequate safety of protecting the permanent specimen 30–33. Moreover, LC cells are morphologically similar to lymphoid cells, thus making identification of metastases more challenging on both IC and definitive postoperative histology 34.…”

Section: Discussionmentioning

confidence: 99%

Imprint cytology versus frozen section analysis for intraoperative assessment of sentinel lymph node in breast cancer

Petropoulou¹,

Kapoula²,

Mastoraki³

et al. 2017

BCTT

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IntroductionSentinel lymph node (SLN) biopsy is the gold standard for surgical staging of the axilla in breast cancer (BC). Frozen section (FS) remains the most popular means of intraoperative SLN diagnosis. Imprint cytology (IC) has also been suggested as a less expensive and equally accurate alternative to FS. The aim of our study was to perform a direct comparison between IC and FS on the same SLNs of BC cases operated in a single center by the same surgical team.Materials and methodsInto this prospective study we enrolled 60 consecutive patients with histologically proven T1–T3 BC and clinically negative axilla. Sentinel nodes were detected using a standard protocol. The SLN(s) was always assessed by IC as well as FS analysis and immunohistochemistry. Nevertheless, all intraoperative decisions were based on FS analysis.ResultsDuring the study period 60 patients with invasive BC were registered, with 80 SLNs harvested. Mean number of SLN(s) identified for each patient was 1.33. The sensitivity and specificity were 90% and 100%, respectively, for IC, and 80% and 100% for FS. Relevant positive/negative predictive values were 100%/98% for IC and 100%/96.15%, respectively, for FS. Overall accuracy was 98% for IC and 97% for FS. Therefore, statistically significant difference between the two methods in the detection of positive nodes was not elucidated (p=1.000).ConclusionsIC appeared to be marginally more sensitive than FS in detecting SLN metastatic activity. Overall accuracy was 98.75%. With regard to the primary lesion characteristics, we conclude that initial lesion size and lymphovascular invasion play a pivotal role in metastatic involvement of the SLN with the dimensions of metastasis bearing no correlation with tumor size. Therefore, IC appears to be a sensitive and accurate method for the intraoperative assessment of SLN in BC patients, but further studies are required to confirm this interesting data.

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Section: Discussionmentioning

confidence: 99%

Imprint cytology versus frozen section analysis for intraoperative assessment of sentinel lymph node in breast cancer

Petropoulou¹,

Kapoula²,

Mastoraki³

et al. 2017

BCTT

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“…All SNs were later formalin fixated, paraffin embedded and stained with hematoxylin-eosin and examined as part of the final histological evaluation. (Figure 1) In cases of doubt, immunohistochemical testing was performed [1].…”

Section: Histopathological Examination Of Sentinel Nodementioning

confidence: 99%

Axillary Recurrences after Sentinel Node Surgery—Results over Ten Years in a University Hospital

Eilertsen¹,

Schlichting²,

Harr³

et al. 2012

JCT

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Background: Sentinel node biopsy (SNB) was introduced at Ullevaal University Hospital in 2000. This article presents results from the first ten years use of the method. Material and Methods: A prospective registration of 2762 patients was made from 2000 through 2009. Results: The median follow-up time was 51 months. The overall detection rate was 93%. 36% of the patients with positive SNs had non-sentinel metastases. These were significantly associated with a macrometastatic SN and a primary tumour>20 mm. 18% of patients with sentinel metastasis≤2 mm had non-sentinel metastases. 14 patients with negative SN (0.7%) developed axillary recurrence. 32% with a preoperative diagnosis of ductal carcinoma in situ (DCIS) were upstaged to infiltrating carcinoma on final histology. None of the patients with pure DCIS had positive SNs. Conclusion: Few late events (0.7%) in SN negative axillas demonstrate the safety of the technique

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Normal and Benign Reactive Hematopoietic Tissues

Valli¹

2007

Veterinary Comparative Hematopathology

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Imprint Cytology of Sentinel Lymph Nodes in Breast Cancer

Cited by 24 publications

References 27 publications

Imprint cytology versus frozen section analysis for intraoperative assessment of sentinel lymph node in breast cancer

Imprint cytology versus frozen section analysis for intraoperative assessment of sentinel lymph node in breast cancer

Axillary Recurrences after Sentinel Node Surgery—Results over Ten Years in a University Hospital

Normal and Benign Reactive Hematopoietic Tissues

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