2008
DOI: 10.1016/j.yfrne.2007.12.001
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Imprinted genes and neuroendocrine function

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Cited by 49 publications
(41 citation statements)
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“…Imprinted genes are known to be a key regulator of placental and hypothalamic development (7,28), and transcriptional silencing produces deficits in maternalism and placental growth, which are functionally coadapted (13). Thus, when Peg3 transcription is inactivated in the hypothalamus of the pregnant mother carrying wild-type offspring, the functional phenotypic outcomes are remarkably similar to those that occur when the same gene is inactivated selectively in the developing placenta and fetal hypothalamus in a wild-type mother (14).…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…Imprinted genes are known to be a key regulator of placental and hypothalamic development (7,28), and transcriptional silencing produces deficits in maternalism and placental growth, which are functionally coadapted (13). Thus, when Peg3 transcription is inactivated in the hypothalamus of the pregnant mother carrying wild-type offspring, the functional phenotypic outcomes are remarkably similar to those that occur when the same gene is inactivated selectively in the developing placenta and fetal hypothalamus in a wild-type mother (14).…”
Section: Discussionmentioning
confidence: 99%
“…The hormones produced by the placenta act on the maternal hypothalamus to silence sexual behavior and reproduction, increase maternal feeding, and prime the brain for postpartum maternal care by activating gene expression for synthesis of oxytocin and its receptors (3,4). The mammalian placenta is linked to the evolution of genomic imprinting (5,6); studies, primarily with mice, have shown that a number of imprinted genes are expressed in both the developing hypothalamus and placenta and influence neuroendocrine function (7). Necdin (8) and Magel2 (9) are two such imprinted genes whose dysregulation results in Prader-Willi syndrome characterized by a failure to suckle and development of a voracious appetite in early childhood.…”
mentioning
confidence: 99%
“…(i) Many IGs are expressed throughout the mouse olfactory system and limbic brain during development and into adulthood, and several encode proteins with known neurodevelopmental and neuroendocrine functionality [7,19,66]. (ii) Several disrupted IG KO mice exhibit disrupted distributions of hormones and their receptors that are known to be important for social behavior (e.g.…”
Section: Box 1 Igs and Mouse Social Behaviormentioning
confidence: 99%
“…It should be emphasized that Germline-Dependent epigenetic modifications are not equivalent to genomic imprinting in which genes are monoallelically expressed in a parent-of-origin dependent manner. 29,30 In the latter case of genomic imprinting, subsets of genes are silenced and influence development; silencing of genes is erased and not transmitted to the next generation. To date, there is but a single example of GermlineDependent epigenetic modification on behavior.…”
Section: Context-dependent Vs Germlinedependent Epigenetic Modificatmentioning
confidence: 99%