Imprinted polymer-based enantioselective acoustic sensor using a quartz crystal microbalance

Haupt, Karsten; Noworyta, Krzysztof; Kutner, Włodzimierz

doi:10.1039/a907844d

Cited by 140 publications

(91 citation statements)

References 22 publications

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“…Nevertheless, there are some reports on the use of quartz crystal microbalance (QCM) [10][11][12][13][14] and surface plasmon resonance (SPR) [15,16] based sensors for enantio-analysis of mixtures. For example, it has been shown that imprinted polymer films could be efficient QCM functional layers for enantioselective detection of serine [10], terpenes [11], dansyl-phenylalanine [12] and propanolol [13]. Paolese et al [14] have shown that a self assembled monolayer (SAM) of a porphyrin diad on a QCM electrode is able to enantio-discriminate analytes in the gas-phase.…”

Section: Introductionmentioning

confidence: 99%

A Cyclodextrin Self-Assembled Monolayer (SAM) Based Surface Plasmon Resonance (SPR) Sensor for Enantioselective Analysis of Thyroxine

Shahgaldian

Hegner

Pieles³

2005

J Incl Phenom Macrocycl Chem

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Heptakis{6-deoxy-6-[12-(thiododecyl) undecanamido-b-cyclodextrin has been produced by reaction of Heptakis(6-deoxy-6-amino)-b-cyclodextrin and 12-(thiododecyl)undecanoic acid using O-Benzotriazol-1-yl-N,N,N¢,N¢-tetramethyluronium tetrafluoroborate (TBTU) as activating agent. Self-assembled monolayers of this macrocycle have been used in a surface plasmon resonance (SPR) sensor; it has been shown that this system is suitable to discriminate between D and L enantiomers of thyroxine, with a greater affinity for the D -enantiomer.

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Section: Introductionmentioning

confidence: 99%

A Cyclodextrin Self-Assembled Monolayer (SAM) Based Surface Plasmon Resonance (SPR) Sensor for Enantioselective Analysis of Thyroxine

Shahgaldian

Hegner

Pieles³

2005

J Incl Phenom Macrocycl Chem

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“…10,[15][16][17][18][19]30 The combination of molecularly imprinted materials (MIPS) and SPR spectroscopy is a potent analytical method for the detection of a given target molecule 19,[31][32][33]35,36 like that of MIPS and surface-enhanced Raman scattering, 37 that of MIPS and conductimetry, 38 that of MIPS and fluorescence, 39 that of MIPS and quartz crystal microbalance (QCM), [40][41][42] and so forth.…”

Section: Adsorption Isotherms Of As and Gs On The 9-ea Imprinted Filmmentioning

confidence: 99%

Surface plasmon resonance studies on molecularly imprinted films

Yoshikawa

Guiver

Robertson

2008

J of Applied Polymer Sci

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Novel molecular recognition films were prepared from modified polysulfone having perillaldehyde moiety as a side group. The molecular recognition films were obtained from perillaldehyde polysulfone by adopting 9-ethyladenine as a print molecule. The molecular recognition phenomena were studied by surface plasmon resonance (SPR) spectroscopy. Adsorption of adenosine (As) and guanosine (Gs) in the molecularly imprinted film was studied. Dual adsorption isotherms were observed for As in 9-EA imprinted films, while nonspecific adsorption isotherms for Gs in those films. This revealed that the molecular recognition sites toward As were constructed in the films thus prepared. The apparent affinity constant toward As determined by using apparent adsorption isotherms ranged from 7.90 Â 10 3 to 3.31 Â 10 4 mol À1 dm 3 .

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“…Specific rebinding of the template occurs because the imprints are complementary to template surface properties, shape, and structure [1,2]. MIPs have demonstrated potential in a variety of fields where defined recognition is required, including separation [3,4], sensing [5][6][7], catalysis [8,9] and drug delivery [10]. Molecular imprinting has previously been applied to small molecules such as amino acids [11,12], toxins [13][14][15] and drugs [16][17][18].…”

Section: Introductionmentioning

confidence: 99%

Formation of protein molecular imprints within Langmuir monolayers: A quartz crystal microbalance study

Turner

Wright

Hlady

et al. 2007

Journal of Colloid and Interface Science

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Protein imprinting leading to enhanced rebinding of ferritin to ternary lipid monolayers is demonstrated using a quartz crystal microbalance. Monolayers consisting of cationic dioctadecyldimethylammonium bromide, non-ionic methyl stearate, and poly(ethylene glycol) bearing phospholipids were imprinted with ferritin at the air/water interface of a Langmuir-Blodgett trough and transferred hydrated to hydrophobic substrates for study. This immobilization was shown by fluorescence correlation spectroscopy to significantly hinder any further diffusion of lipids, while rebinding studies demonstrated up to a six-fold increase in ferritin adsorption to imprinted versus control monolayers. A diminished rebinding of ferritin to its imprint was observed through pH reduction to below the protein isoelectric point, demonstrating the electrostatic nature of the interaction. Rebinding to films where imprint pockets remained occupied by the template protein was also minimal. Studies with a smaller acidic protein revealed the importance of the steric influence of poly(ethylene glycol) in forming the protein binding pockets, as albumin-imprinted monolayers showed low binding of ferritin, while ferritin-imprinted monolayers readily accommodated albumin. The controllable structure-function relationship and limitations of this system are discussed with respect to the application of protein imprinting in sensor development as well as fundamental studies of proteins at dynamic interfaces.

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Imprinted polymer-based enantioselective acoustic sensor using a quartz crystal microbalance

Cited by 140 publications

References 22 publications

A Cyclodextrin Self-Assembled Monolayer (SAM) Based Surface Plasmon Resonance (SPR) Sensor for Enantioselective Analysis of Thyroxine

A Cyclodextrin Self-Assembled Monolayer (SAM) Based Surface Plasmon Resonance (SPR) Sensor for Enantioselective Analysis of Thyroxine

Surface plasmon resonance studies on molecularly imprinted films

Formation of protein molecular imprints within Langmuir monolayers: A quartz crystal microbalance study

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