2024
DOI: 10.21203/rs.3.rs-4335092/v1
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Imprinting of B cells in SARS-CoV-2 prototype strain infection compared to AZD1222 (ChAdOx nCoV-19) vaccination

Débora Familiar-Macedo,
Elzinandes Leal de Azeredo,
Elba Regina Sampaio Lemos
et al.

Abstract: Understanding the behavior of B cell subsets in infections and vaccination is important to determine how protective humoral immunity is established. Here, we performed a cross-sectional study and evaluated subjects who were either acutely infected with SARS-CoV-2, recovered from COVID-19, or received two doses of the AZD1222 vaccine. PBMC collected from these subjects were subjected to in vitro stimulation with R848 + rIL-2 to promote terminal differentiation of B cells into antibody-secreting cells (ASC), and… Show more

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