Improve it or lose it: Evolvability cost of competition for expression

Moran, Jacob; Finlay, D. E.; Tikhonov, Mikhail

doi:10.1103/physreve.103.062402

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“…All simulations were performed in MATLAB (Mathworks, Inc.). The associated code, data and scripts to reproduce all figures in this work are available at Mendeley Data, http://dx.doi.org/10.17632/zdsnttv2dt.1 [23].…”

Section: Data Availabilitymentioning

confidence: 99%

Improve it or lose it: evolvability costs of competition for expression

Moran,

Finlay,

Tikhonov

2020

Preprint

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Expression level is known to be a strong determinant of a protein's rate of evolution. But the converse can also be true: evolutionary dynamics can affect expression levels of proteins. Having implications in both directions fosters the possibility of a feedback loop, where higher expressed systems are more likely to improve and be expressed even higher, while those that are expressed less are eventually lost to drift. Using a minimal model to study this in the context of a changing environment, we demonstrate that one unexpected consequence of such a feedback loop is that a slow switch to a new environment can allow genotypes to reach higher fitness sooner than a direct exposure to it.

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Section: Data Availabilitymentioning

confidence: 99%