Improve Solubility and Bioavailability of Silver Sulfadiazine via Formation of Inclusion Complex by Cyclodextrin

Amiri, Sahar; Nalbandi, Bahareh

doi:10.1007/s10904-018-0809-8

Cited by 12 publications

(18 citation statements)

References 17 publications

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“…XRD is one of the most accurate methods for characterising the formation of inclusion complexes between HP-β-CD and guest molecules. The crystalline properties of a guest molecule can change upon forming an inclusion complex with HP-β-CD [25,31]. Figure 2 shows that the X-ray diffraction pattern of HP-β-CD has a broad diffraction peak at 2θ of 9.6° and 24.7°, confirming its amorphous structure [27].…”

Section: Xrd Analysismentioning

confidence: 92%

“…The melting point of GSE disappeared, and the thermal properties of HP-β-CD were altered following formation of the inclusion complex between GSE and HP-β-CD, resulting in a shift in the melting peak. DSC analysis provides exhaustive data related to physical changes [32] and can be used to determine the formation of solid inclusion complexes, and the disappearance of thermal peaks containing the guest molecule further indicates the successful preparation of the inclusion complex [25,31,33].…”

Section: Xrd Analysismentioning

confidence: 99%

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Preparation and Characterisation of Polyphenol-HP-β-Cyclodextrin Inclusion Complex that Protects Lamb Tripe Protein against Oxidation

Lidan

Liu

et al. 2019

Molecules

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Grape seed extract (GSE) displays strong antioxidant activity, but its instability creates barriers to its applications. Herein, three HP-β-CD/GSE inclusion complexes with host–guest ratios of 1:0.5, 1:1, and 1:2 were successfully prepared by co-precipitation method to improve stability. Successful embedding of GSE in the HP-β-CD cavity was confirmed by fourier-transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), differential scanning calorimetry (DSC), and scanning electron microscopy (SEM) analyses. The Autodock Tools 1.5.6 was used to simulate the three-dimensional supramolecular structure of the inclusion complex of 2-hydroxypropyl-β-cyclodextrin and grape seed extract (HP-β-CD/GSE) by molecular docking. The MALDI-TOF-MS technology and chemical database Pubchem, and structural database PDB were combined to reconstitute the three-dimensional structure of target protein. The binding mode of the HP-β-CD/GSE inclusion complex to target protein was studied at the molecular level, and the antioxidant ability of the resulting HP-β-CD/GSE inclusion complexes was investigated by measuring 2,2-diphenyl-1-picrylhydrazyl (DPPH) free radical scavenging. The effects of HP-β-CD/GSE on myofibrillar protein from lamb tripe were also investigated under oxidative conditions. The positions and interactions of the binding sites of HP-β-CD/GSE inclusion complexes and target protein receptors were simulated by molecular docking. The results showed that HP-β-CD/GSE inclusion complexes were successfully prepared, optimally at a molar ratio of 1:2. At low (5 μmol/g) to medium (105 μmol/g) concentrations, HP-β-CD/GSE inclusion complexes decreased the carbonyl content, hydrophobicity, and protein aggregation of myofibrillar protein from lamb tripe, and increased the sulphydryl content. Furthermore, high concentration (155 μmol/g) of HP-β-CD/GSE inclusion complexes promoted protein oxidation.

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Section: Xrd Analysismentioning

confidence: 92%

Section: Xrd Analysismentioning

confidence: 99%

Preparation and Characterisation of Polyphenol-HP-β-Cyclodextrin Inclusion Complex that Protects Lamb Tripe Protein against Oxidation

Lidan

Liu

et al. 2019

Molecules

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“…Effect of light on drug toxicity [3]. hydrophobic cavity of cyclodextrins [5] [6]. CDs can encapsulate the hydrophobic substances into their cavities and prevent the direct contact of substances with light.…”

Section: Formation Of Inclusion Complex May Change Guest Molecules Prmentioning

confidence: 99%

“…CDs can encapsulate the hydrophobic substances into their cavities and prevent the direct contact of substances with light. In fact, if using CD, we can cover some parts of ofloxacin which show light sensitivity and are degraded by contact with light, then the degradation rate will be significantly reduced and the drug exposed to light will maintain its integrity and efficacy for a longer time [5] [6].…”

Section: Formation Of Inclusion Complex May Change Guest Molecules Prmentioning

confidence: 99%

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PVA Nanofibers Containing Ofloxacin-Cyclodextrin Inclusion Complex: Improve Optical Stability of Ofloxacin

Mehrizi¹,

Amiri²,

Bahrami³

2019

OJOPM

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Ofloxacin is an antibiotic with a wide range of activity against bacterial infections, but due to the high potential for toxicity when exposed to light, resolving this problem and further stabilizing the drug are among the posed challenges. Inclusion complex formation between α-cyclodextrin (α-CD), ofloxacin (OFL) and polyethylene glycol (PEG) was prepared via two methods to produce nanocontainers with desirable stability. The effect of PEG as compatible solubilizing agent and mixing condition (in ultrasonic bath) were investigated in formation of an inclusion complex between α-CD/OFL. Obtained complexes were examined by FTIR, H-NMR, SEM, EDX and UV which indicated the formation of an inclusion complex between α-CD/OFL, in turn, is a mixture of the cage and channel structures. Differences between 1 H-NMR, FTIR and XRD spectra of OFL, CDs and inclusion complex indicated the formation of α-CD/OFL and supramolecular containers in solid phase. These inclusion complexes loaded in PVA-based nanofibers for smart nanofibers with controlled release manner and higher stability of OFL. Obtained nanofiber showed that nanofibers containing CDs/OFL under sonic energy containing higher degree of OFL.

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CDs: A Potential Candidate for Improving Water Solubility and Stability of Hydrophobic Guest Molecules

Amiri

2022

Micro- And Nano-Containers for Smart Applications

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Improve Solubility and Bioavailability of Silver Sulfadiazine via Formation of Inclusion Complex by Cyclodextrin

Cited by 12 publications

References 17 publications

Preparation and Characterisation of Polyphenol-HP-β-Cyclodextrin Inclusion Complex that Protects Lamb Tripe Protein against Oxidation

Preparation and Characterisation of Polyphenol-HP-β-Cyclodextrin Inclusion Complex that Protects Lamb Tripe Protein against Oxidation

PVA Nanofibers Containing Ofloxacin-Cyclodextrin Inclusion Complex: Improve Optical Stability of Ofloxacin

CDs: A Potential Candidate for Improving Water Solubility and Stability of Hydrophobic Guest Molecules

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