Improved accuracy of intraocular lens power calculation by preoperative management of dry eye disease

Abstract

Background To evaluate the effects of pretreatment for dry eye disease (DED) on the accuracy of intraocular lens (IOL) power calculation. Methods Patients who underwent uneventful cataract surgery were included in the study. IOL power was determined using the SRK/T and Barrett Universal II (Barrett) formulas. The patients were divided into non-pretreatment and pretreatment groups, and those in the pretreatment group were treated with topical 0.5% loteprednol etabonate and 0.05% cyclosporin A for 2 weeks prior to cataract surgery. Ocular biometry was performed in all groups within 2 days before surgery. The mean prediction error, mean absolute error (MAE), and proportions of refractive surprise were compared between the non-pretreatment and pretreatment groups at 1 month postoperatively. Refractive surprise was defined as MAE ≥ 0.75D. Results In a total of 105 patients, 52 (52 eyes) were in the non-pretreatment group and 53 (53 eyes) in the pretreatment group. The MAE was 0.42 ± 0.33, 0.38 ± 0.34 (SRK/T, Barrett) and 0.23 ± 0.19, 0.24 ± 0.19 in the non-pretreatment and pretreatment groups, respectively (p < 0.001/=0.008). The number of refractive surprises was also significantly lower in the pretreatment group. [non-pretreatment/pretreatment: 9/2 (SRK/T); 8/1 (Barrett); p = 0.024/0.016]. Pretreatment of DED was related to a reduction in postoperative refractive surprise. [SRK/T/Barrett: OR = 0.18/0.17 (95% CI: 0.05–0.71/0.05–0.60), p = 0.014/0.006]. Conclusions The accuracy of IOL power prediction can be increased by actively treating DED prior to cataract surgery.

Repeatability of biometry in patients with meibomian gland dysfunction before and after vectored thermal pulsation therapy: A randomized, controlled trial

“…It is therefore mandatory to rule out any source of error in the preoperative setting to reduce the risk of postoperative refractive surprise. DED is a condition with high prevalence especially in the elderly population and has already been linked to impreciseness of preoperative biometry, particularly anterior keratometry, in previous clinical studies (Doğan et al, 2018; Epitropoulos et al, 2015; Kim et al, 2021). Within this study, we could not detect significant differences regarding the repeatability of EIOLP and other keratometry measures after VTPT therapy.…”

“…the epithelium, but is rather based on reflections of the tear film. Consequently, recent studies have investigated the influence of the tear film constitution on the repeatability of keratometry measurements (Epitropoulos et al, 2015; Gjerdrum et al, 2020; Kim et al, 2021; Röggla et al, 2021).…”

Investigating the Anti-Inflammatory Effects of RCI001 for Treating Ocular Surface Diseases: Insight Into the Mechanism of Action

“…Additionally, anti-inflammatory monoclonal antibodies, such as infliximab, adalimumab, tocilizumab, and rituximab, afford limited application against OSDs and remain extremely expensive. We have previously demonstrated the clinical efficacy of corticosteroids in managing DED ( 24 , 25 ). Nonetheless, the long-term use of topical corticosteroids can induce potential risks such as secondary infection, elevated intraocular pressure, and cataract formation ( 26 ).…”

Enhancement-Optionen nach Linsen- und refraktiver Hornhautchirurgie

“…Beobachtungsstudien haben gezeigt, dass ein symptomatisches trockenes Auge nach einer Kataraktoperation bei Patienten auftreten kann, die präoperativ keine oder nur minimale Beschwerden aufwiesen 24 . Darüber hinaus konnte nachgewiesen werden, dass ein präoperativ bestehendes trockenes Auge zu Messfehlern bei der IOL-Berechnung führt 25 .…”