Improved Air Quality and Attenuated Lung Function Decline: Modification by Obesity in the SAPALDIA Cohort

Schikowski, Tamara; Schaffner, Emmanuel; Meier, Flurina; Phuleria, Harish C.; Vierkötter, Andrea; Schindler, Christian; Kriemler, Susi; Zemp, Elisabeth; Krämer, Ursula; Bridevaux, Pierre‐Olivier; Rochat, Thierry; Schwartz, Joel; Künzli, Nino; Probst‐Hensch, Nicole

doi:10.1289/ehp.1206145

Cited by 55 publications

(42 citation statements)

References 51 publications

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“…We found no study with stratified analysis on BMI or dietary factors, despite of the known association between BMI and asthma [43]. Several papers suggested that obesity can play a role in susceptibility to pollutants effects [41,42] in lung function, and in a randomized-trial [56] antioxidant intake was associated with a moderate impact of ozone exposure on lung function in children with moderate to severe asthma. Whereas susceptibility of older adults to the health effects of air pollution is well recognized, and particularly on lung function [57] where frailty was associated with a higher decline of forced vital capacity due to air pollution, we did not find study stratifying on these factors.…”

Section: Overall Discussion and Conclusionmentioning

confidence: 77%

“…-Body mass index (BMI): subjects with obesity have been found to be more susceptible to air pollution in terms of lung function (and as lung function is an asthma related phenotype, it seems plausible that susceptibility factors related to lung function may also be interesting to study regarding asthma incidence) and asthma [41][42][43].…”

Section: Susceptibility Factorsmentioning

confidence: 99%

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Susceptibility Factors Relevant for the Association Between Long-Term Air Pollution Exposure and Incident Asthma

Burte

Nadif

Jacquemin

2016

Curr Envir Health Rpt

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In this review, we identified 15 studies in children and 10 studies in adults that assessed the association between long-term exposure to air pollution and incident asthma and that conducted stratified analyses to explore potential susceptibility factors. Overall, adult never/former smokers seem to be at higher risk of incident asthma due to air pollution. Children without atopy and children from low socio-economic status families also seem to be at higher risk of incident asthma due to air pollution. While interaction between air pollution and genes involved in the response to oxidative stress pathways have been explored, results are somewhat inconsistent and in need of replication. To evaluate interactions, large sample sizes are necessary and much more research, including data pooling 2 from existing studies, is needed to further explore susceptible factors for asthma incidence due to long-term air pollution exposure.

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Section: Overall Discussion and Conclusionmentioning

confidence: 77%

Section: Susceptibility Factorsmentioning

confidence: 99%

Susceptibility Factors Relevant for the Association Between Long-Term Air Pollution Exposure and Incident Asthma

Burte

Nadif

Jacquemin

2016

Curr Envir Health Rpt

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show abstract

“…For example, improvements were not observed in symptoms following an allergen-reducing indoor air quality intervention in a public housing complex among asthmatic children reporting exposure to a psychosocial risk factor (e.g., fear of violence) [55]. Similarly, improved air quality was associated with a slower rate of decline in several lung function parameters among non-obese but not among obese participants in a study of Swiss adults [56]. Counter to initial hypotheses, those with factors typically thought to confer increased susceptibility to the adverse effects of air pollution exposures (e.g., psychosocial factors and obesity) did not experience greater benefits following reductions in air pollution exposures.…”

Section: Who Benefits From Cleaner-burning Cookstove Interventions Anmentioning

confidence: 99%

Perspectives in Household Air Pollution Research: Who Will Benefit from Interventions?

Clark

Peel

2014

Curr Envir Health Rpt

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Household air pollution from solid fuel combustion in inefficient and poorly vented cookstoves is estimated to be responsible for 3.9 million premature deaths per year and 4.8 % of the global burden of disease, making it the third leading risk factor for morbidity and mortality worldwide. Despite increasing recognition surrounding this global environmental health problem, much remains to be elucidated regarding exposure response relationships, particularly among potentially susceptible population subgroups. Given that many of the communities most affected by household air pollution exposures also experience elevated exposures to poverty, psychosocial stressors, other environmental pollutants, and comorbid conditions, research needs to correctly specify risks due to these potentially interacting risk factors. Although suggestive evidence exists for differential improvements in health following reductions in ambient air pollution concentrations among specific subgroups, the question remains as to who will benefit and to what extent from efforts to reduce exposures to emissions from household solid fuel combustion. The ability to know what to expect from cookstove interventions and to accurately describe the presence of distinct subgroup responses is crucial to reduce uncertainty and to encourage policy makers to enact change.

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“…Although previous reports have shown significant synergistic effects of obesity and exposure to ambient air pollutants such as nitrogen dioxide (NO 2 ) and PM 10 content on lung function using an indirect measurement of obesity including body mass index (BMI), 6,13,14 accurate quantitative measurement of adipose tissue mass by computed tomography (CT) is needed to understand the plausible mechanisms between adipose tissue and air pollution in lung function. However, to our knowledge, no studies have investigated whether there is an additive effect of fat accumulation in adipose tissue on the relationship between ambient air pollution and lung function.…”

Section: Introductionmentioning

confidence: 99%

Abdominal adiposity intensifies the negative effects of ambient air pollution on lung function in Korean men

Kim

et al. 2017

Int J Obes

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BACKGROUND: Some studies have provided the possibility that adipose tissue may mediate air pollution-induced lung dysfunction. Studies using quantified fat mass data are needed to understand the biological mechanisms between adipocyte and air pollution in lung function. We aimed to investigate whether abdominal adiposity measured by computed tomography (CT) modifies the effects of air pollution on lung function in Korean men. METHODS: A total of 1876 men who visited one of two health checkup centers were recruited for this study. Adiposity traits such as visceral adipose tissue (VAT), subcutaneous adipose tissue (SAT) and total adipose tissue (TAT) areas were measured by CT. We used the annual mean concentrations of ambient air pollutants including nitrogen dioxide (NO 2 ) and particulate matter with an aerodynamic diameter ⩽ 10 μm (PM 10 ). RESULTS: Interquartile range (IQR) increase in annual mean concentration of NO 2 was significantly associated with a 2.5% lower forced expiratory volume in 1 s (FEV 1 ) and 2.9% lower forced vital capacity (FVC) (both P o0.05). The decrease in lung function was more strongly associated with adiposity traits than with body mass index. In a stratified analysis of adiposity, compared with subjects with low-VAT area (VAT ⩽ 200 cm 2 ), those with high-VAT area (VAT4200 cm 2 ) showed a rapid decrease in FEV 1 with each IQR increase in PM 10 (β = -0.0812; 95% confidence interval (CI) = -0.1590, -0.0035) and NO 2 (β = -0.0979; 95% CI = -0.1611, -0.0346). In the high-VAT group, each IQR increase in NO 2 content was significantly associated with a 10.6% decrease (β = -0.1056; 95% CI = -0.1770, -0.0343) in FVC. SAT and TAT areas showed similar patterns. CONCLUSIONS: We report the first finding that abdominal adiposity intensifies the inverse relationship between air pollution and lung function.

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Improved Air Quality and Attenuated Lung Function Decline: Modification by Obesity in the SAPALDIA Cohort

Cited by 55 publications

References 51 publications

Susceptibility Factors Relevant for the Association Between Long-Term Air Pollution Exposure and Incident Asthma

Susceptibility Factors Relevant for the Association Between Long-Term Air Pollution Exposure and Incident Asthma

Perspectives in Household Air Pollution Research: Who Will Benefit from Interventions?

Abdominal adiposity intensifies the negative effects of ambient air pollution on lung function in Korean men

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