Improved and rapid synthesis of new coumarinyl chalcone derivatives and their antiviral activity

Antimicrobial and Antileishmanial Studies of Novel (2E)-3-(2-Chloro-6-methyl/methoxyquinolin-3-yl)-1-(Aryl)prop-2-en-1-ones

“…5,6) Chalcones, either natural or synthetic, are known to exhibit various biological activities such as anti-inflammatory, 7,8) antifungal, [9][10][11][12] antioxidant, [13][14][15][16] antimalarial, [17][18][19][20] antituberculosis, 21) analgesic, 22) anti-human immunodeficiency virus (HIV) 23) and antitumor activities. [23][24][25] Some of them act as anticancer, 26) antiviral 27) and anti-AIDS agents. 28) Quinoline-based chalcones have been reported to possess antimalarial activity.…”

Crystal structure of (E)-2-(4-hydroxy-3-methoxybenzylidene)-6-methoxy-3,4-dihydronaphthalen-1(2H)-one, C19H18O4

“…This synthon is considered as a versatile building block that can be used to construct heterocyclic rings having one or more heteroatoms and of di erent ring sizes such as 2-pyrazoline [1], pyrimidine [2,3], pyran, and isooxazoline [4]. Generally chalcones and their analogs are prepared by Claisen-Schmidt reactions under basic conditions using bases such as sodium hydroxide or potassium hydroxide [5], lithium hydroxide [6] and piperidine [7]. Acid catalyzed synthesis is also well established using p-toluene sulfonic acid under focused microwave irradiation [8], thionyl chloride [9], dry hydrochloric acid and borontri uoride-etherate [10].…”

Crystal Structures of Two Macrocyclic Bischalcones Possessing 26-Membered Rings

“…Compounds containing the chalcone (1,3-diphenyl-2-propen-1-one) moiety [1] are known to possess important biological activities such as antimicrobial [2], antiviral [3], antibacterial [4,5], antihelminthic [5], antimalarial [6,7], and antitumor [8] activities. Moreover, these compounds can be transformed in a number of ways into other biologically active heterocycles, for example, pyrimidines [9], isoxazole and pyrazole [10], and pyridines [11].…”