Improved anti-breast cancer activity by doxorubicin-loaded super stealth liposomes

Paolino, Donatella; d'Avanzo, Nicola; Canato, Elena; Ciriolo, Luigi; Grigoletto, Antonella; Cristiano, Maria Chiara; Mancuso, Antonia; Celia, Christian; Pasut, Gianfranco; Fresta, Massimo

doi:10.1039/d4bm00478g

Biomater. Sci.

2024

DOI: 10.1039/d4bm00478g

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Improved anti-breast cancer activity by doxorubicin-loaded super stealth liposomes

Donatella Paolino,

Nicola d'Avanzo,

Elena Canato

et al.

Abstract: PEGylated dendron phospholipids increase the anchoring effect of PEG to Dox-loaded liposomes, thus improving the pharmacokinetic profile and anti-cancer effect in breast cancer lung metastasis tumor-bearing mice.

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Lipid Nanovesicles for Antioxidant Delivery in Skin: Liposomes, Ufasomes, Ethosomes, and Niosomes

Ricci,

Stefanuto,

Gasperi

et al. 2024

Antioxidants

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The skin, being the largest organ of the human body, serves as the primary barrier against external insults, including UV radiation, pollutants, and microbial pathogens. However, prolonged exposure to these environmental stressors can lead to the generation of reactive oxygen species (ROS), causing oxidative stress, inflammation, and ultimately, skin aging and diseases. Antioxidants play a crucial role in neutralizing ROS and preserving skin health by preventing oxidative damage. In recent years, nanotechnology has emerged as a powerful tool for enhancing the delivery of antioxidants onto the skin. In particular, liposomal formulations have offered unique advantages such as improved stability, controlled release, and enhanced penetration through the skin barrier. This has led to a surge in research focused on developing liposomal-based antioxidant delivery systems tailored for skin health applications. Through a comprehensive analysis of the literature from the 2019–2024 period, this review provides an overview of emerging trends in the use of liposomal delivery systems developed for antioxidants aimed at improving skin health. It explores the latest advancements in liposomal formulation strategies, vesicle characterization, and their applications in delivering antioxidants to combat oxidative stress-induced skin damage and other associated skin pathologies. A comparison of various delivery systems is conducted for the most common antioxidants. Finally, a brief analysis of lipid nanovesicles used in the cosmeceutical industry is provided.

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Lipid Nanovesicles for Antioxidant Delivery in Skin: Liposomes, Ufasomes, Ethosomes, and Niosomes

Ricci,

Stefanuto,

Gasperi

et al. 2024

Antioxidants

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show abstract

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Improved anti-breast cancer activity by doxorubicin-loaded super stealth liposomes

Abstract: PEGylated dendron phospholipids increase the anchoring effect of PEG to Dox-loaded liposomes, thus improving the pharmacokinetic profile and anti-cancer effect in breast cancer lung metastasis tumor-bearing mice.

Cited by 1 publication

References 64 publications

Lipid Nanovesicles for Antioxidant Delivery in Skin: Liposomes, Ufasomes, Ethosomes, and Niosomes

Lipid Nanovesicles for Antioxidant Delivery in Skin: Liposomes, Ufasomes, Ethosomes, and Niosomes

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