Improved anti-Cutibacterium acnes activity of tea tree oil-loaded chitosan-poly(ε-caprolactone) core-shell nanocapsules

Silva, Natália Prado da; Pereira, Eloá Do Carmo Rapozo Lavinas; Duarte, Lucas Mattos; Freitas, Jhamine Caroline de Oliveira; Almeida, Camila G. de; Silva, Thiago Pereira da; Melo, Rossana C. N.; Apolônio, Ana Carolina Morais; Oliveira, Marcone Augusto Leal de; Brandão, Humberto M.; Pittella, Frederico; Fabri, Rodrigo Luiz; Tavares, Guilherme Diniz; Pinto, Priscila de Faria

doi:10.1016/j.colsurfb.2020.111371

Cited by 31 publications

(19 citation statements)

References 51 publications

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“…The results demonstrated that MIC values of TTO, NC-CS, and NC-TTO-CS against C. acnes were 0.56% v / v , greater than 0.56% v / v , and 0.14% v / v , respectively. Four-fold enhancement in antibacterial activity observed for NC-TTO-CS against C. acnes was attributed to synergism between TTO and CS proving nanocapsules as a promising vehicle for TTO topical delivery in acne therapy [ 157 ]. Rozman et al synthesized Homalomenapineodora essential oil-loaded chitosan nanoparticles (HP-CSNPs) using an ion gelation method to suppress diabetic microorganisms.…”

Section: Nanoparticles As Carriers Of Eomentioning

confidence: 99%

Nanoparticles—Attractive Carriers of Antimicrobial Essential Oils

et al. 2022

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Microbial pathogens are the most prevalent cause of chronic infections and fatalities around the world. Antimicrobial agents including antibiotics have been frequently utilized in the treatment of infections due to their exceptional outcomes. However, their widespread use has resulted in the emergence of multidrug-resistant strains of bacteria, fungi, viruses, and parasites. Furthermore, due to inherent resistance to antimicrobial drugs and the host defence system, the advent of new infectious diseases, chronic infections, and the occurrence of biofilms pose a tougher challenge to the current treatment line. Essential oils (EOs) and their biologically and structurally diverse constituents provide a distinctive, inexhaustible, and novel source of antibacterial, antiviral, antifungal, and antiparasitic agents. However, due to their volatile nature, chemical susceptibility, and poor solubility, their development as antimicrobials is limited. Nanoparticles composed of biodegradable polymeric and inorganic materials have been studied extensively to overcome these limitations. Nanoparticles are being investigated as nanocarriers for antimicrobial delivery, antimicrobial coatings for food products, implantable devices, and medicinal materials in dressings and packaging materials due to their intrinsic capacity to overcome microbial resistance. Essential oil-loaded nanoparticles may offer the potential benefits of synergism in antimicrobial activity, high loading capacity, increased solubility, decreased volatility, chemical stability, and enhancement of the bioavailability and shelf life of EOs and their constituents. This review focuses on the potentiation of the antimicrobial activity of essential oils and their constituents in nanoparticulate delivery systems for a wide range of applications, such as food preservation, packaging, and alternative treatments for infectious diseases.

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Section: Nanoparticles As Carriers Of Eomentioning

confidence: 99%

Nanoparticles—Attractive Carriers of Antimicrobial Essential Oils

et al. 2022

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“…Antimicrobial and antibiotics Fluoxetine Polymeric [54] Carvacrol Polymeric [55] Amoxicillin Polymeric [56] Florfenicol Polymeric [57] Tea tree oil Polymeric [58] Fusidic acid Lipid [59] Albendazole Lipid [60] Anticancer drugs Curcumin Polymeric [61][62][63] Hybrid lipid [64] Liquid lipid [65,66] Docetaxel Polymeric [67,68] Lipid [69] Perillyl alcohol Polymeric [70] Tamoxifen Polymeric [71,72] Aprepitant Polymeric [73] 5-fluoroacil Polymeric [74,75] Doxorubicin Polymeric [76] Paclitaxel Polymeric [77,78] Lipid [79] Oleic acid Hybrid [80] Simvastatin Hybrid [81] Thymoquinone Polymeric [82] Gemcitabine Lipid [83] Phloretin Lipid [84] Itraconazole Lipid [85,86] Regorafenib Lipid [87] Sorafenib Lipid [88] Imatinib Lipid [89] Ifosfamide Lipid [90] Vinorelbine Lipid [91] Anti . Chitosan-PCL core-shell nanocapsules were obtained and loaded with tea tree oil.…”

Section: Pharmacological Group Drug/compound Type Of Nanocapsule Refe...mentioning

confidence: 99%

Lipid and Polymeric Nanocapsules

Rochín-Wong¹,

Rivas²

2022

Drug Carriers

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In recent years, innovative drug nanocarriers have been developed to enhance stability, bioavailability, and provide sustained release. In this chapter, systems based on natural macromolecules, lipids, or polymeric/polyelectrolyte nanocapsules and their principal chemical and functional characteristics are described. Nano-vesicular systems are especially relevant in different fields. Particularly, a promising potential is offered by systems based on colloidal nanocapsules, that exhibit a typical core-shell structure in which the drug can be confined into the cavity or in the polymeric coating that surrounds it. Both the cavity and the active substance can be lipophilic or hydrophilic and in solid or liquid form depending on the materials and methods used, making these nanocapsules attractive carriers for drug delivery. In addition, a compilation of different methods and materials employed in the preparation of these nanosystems and a recent review of applications of lipid and polymeric nanocapsules have been made, focussing on the encapsulation of drugs.

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“…As communicable diseases threaten to reach epidemic proportions, affecting patients from all ages, societal and financial status, with high mortality rates and healthcare burden, the search for effective antimicrobial strategies is highly needed. In parallel, plant extracts (widely used as folk medicine) are increasingly considered as potential alternatives to antibiotics, having high potential for being a source of natural drugs that can be used to counteract microbial survival and prosperity [ 22 , 54 , 55 ]. Several natural drugs have already been approved for clinical use, namely for antioxidant and antimicrobial purposes [ 178 , 179 ].…”

Section: Conclusion and Future Perspectivesmentioning

confidence: 99%

Bioactivity of Chitosan-Based Particles Loaded with Plant-Derived Extracts for Biomedical Applications: Emphasis on Antimicrobial Fiber-Based Systems

et al. 2021

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Marine-derived chitosan (CS) is a cationic polysaccharide widely studied for its bioactivity, which is mostly attached to its primary amine groups. CS is able to neutralize reactive oxygen species (ROS) from the microenvironments in which it is integrated, consequently reducing cell-induced oxidative stress. It also acts as a bacterial peripheral layer hindering nutrient intake and interacting with negatively charged outer cellular components, which lead to an increase in the cell permeability or to its lysis. Its biocompatibility, biodegradability, ease of processability (particularly in mild conditions), and chemical versatility has fueled CS study as a valuable matrix component of bioactive small-scaled organic drug-delivery systems, with current research also showcasing CS’s potential within tridimensional sponges, hydrogels and sutures, blended films, nanofiber sheets and fabric coatings. On the other hand, renewable plant-derived extracts are here emphasized, given their potential as eco-friendly radical scavengers, microbicidal agents, or alternatives to antibiotics, considering that most of the latter have induced bacterial resistance because of excessive and/or inappropriate use. Loading them into small-scaled particles potentiates a strong and sustained bioactivity, and a controlled release, using lower doses of bioactive compounds. A pH-triggered release, dependent on CS’s protonation/deprotonation of its amine groups, has been the most explored stimulus for that control. However, the use of CS derivatives, crosslinking agents, and/or additional stabilization processes is enabling slower release rates, following extract diffusion from the particle matrix, which can find major applicability in fiber-based systems within ROS-enriched microenvironments and/or spiked with microbes. Research on this is still in its infancy. Yet, the few published studies have already revealed that the composition, along with an adequate drug release rate, has an important role in controlling an existing infection, forming new tissue, and successfully closing a wound. A bioactive finishing of textiles has also been promoting high particle infiltration, superior washing durability, and biological response.

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Improved anti-Cutibacterium acnes activity of tea tree oil-loaded chitosan-poly(ε-caprolactone) core-shell nanocapsules

Cited by 31 publications

References 51 publications

Nanoparticles—Attractive Carriers of Antimicrobial Essential Oils

Nanoparticles—Attractive Carriers of Antimicrobial Essential Oils

Lipid and Polymeric Nanocapsules

Bioactivity of Chitosan-Based Particles Loaded with Plant-Derived Extracts for Biomedical Applications: Emphasis on Antimicrobial Fiber-Based Systems

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