Improved Antigenic Methods for Differential Diagnosis of Bovine, Caprine, and Cervine Alphaherpesviruses Related to Bovine Herpesvirus 1

Keuser, Véronique; Schynts, Frédéric; Detry, Bruno; Collard, Alfred; Robert, B; Vanderplasschen, Alain; Pastoret, Paul-Pierre; Thiry, Étienne

doi:10.1128/jcm.42.3.1228-1235.2004

Cited by 32 publications

(24 citation statements)

References 53 publications

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“…More recently, an immunofluorescence assay able to differentiate the five related herpesviruses has been developed. This method is based on the use of four monoclonal antibodies directed against gC, and one against gD, of these related viruses [62] (Fig. 4). …”

Section: Virological Diagnosismentioning

confidence: 99%

Ruminant alphaherpesviruses related to bovine herpesvirus 1

et al. 2006

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-Herpesviruses have mainly co-evolved with their hosts for millions of years. Consequently, different related host species may have been infected by various genetically related herpesviruses. Illustrating this concept, several ruminant alphaherpesviruses have been shown to form a cluster of viruses closely related to bovine herpesvirus 1 (BoHV-1): namely bovine herpesvirus 5, bubaline herpesvirus 1, caprine herpesvirus 1, cervid herpesviruses 1 and 2 and elk herpesvirus 1. These viruses share common antigenic properties and the serological relationships between them can be considered as a threat to BoHV-1 eradication programmes. BoHV-1 is a herpesvirus responsible for infectious bovine rhinotracheitis, which is a disease of major economic concern. In this article, the genetic properties of these ruminant alphaherpesviruses are reviewed on a comparative basis and the issue of interspecific recombination is assessed. The pathogenesis of these infections is described with emphasis on the host range and crossing of the host species barrier. Indeed, the non bovine ruminant species susceptible to these ruminant alphaherpesviruses may be potential BoHV-1 reservoirs. The differential diagnosis of these related infections is also discussed. In addition, available epidemiological data are used to assess the potential of cross-infection in ruminant populations. A better knowledge of these ruminant alphaherpesvirus infections is essential to successfully control infectious bovine rhinotracheitis.

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Section: Virological Diagnosismentioning

confidence: 99%

Ruminant alphaherpesviruses related to bovine herpesvirus 1

et al. 2006

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“…In order to develop a specific immunofluorescence assay for BoHV-1.2 and BoHV-5, MAbs were first selected by flow cytometric analysis as previously described (28).…”

Section: Methodsmentioning

confidence: 99%

Interspecific Recombination between Two Ruminant Alphaherpesviruses, Bovine Herpesviruses 1 and 5

Meurens

Keil

Muylkens

et al. 2004

J Virol

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Homologous recombination between different species of alphaherpesviruses has been described between herpes simplex viruses 1 and 2 but has not yet been observed between other alphaherpesviruses. In the present study we chose to assess to what extent in vitro recombination can occur between members of a well-defined group of closely related viruses such as ruminant alphaherpesviruses. At 24 h after infection of epithelial bovine kidney cells with a double-deleted mutant of bovine herpesvirus 1 (BoHV-1) (containing green fluorescent protein and red fluorescent protein genes) and different ruminant alphaherpesviruses, four types of progeny viruses were detected and distinguished according to their phenotype. Frequent recombination events between identical or different strains of BoHV-1 were observed (up to 30%), whereas only two BoHV-1/BoHV-5 recombinants were identified, and no recombinants between BoHV-1 and less closely related caprine and cervine herpesviruses were detected. Restriction analysis of the genomes of the two BoHV-1/BoHV-5 recombinants showed different genetic backgrounds. One possessed a restriction pattern close to BoHV-1, whereas the other one was close to BoHV-5. This exhaustive analysis of each combination of coinfection in a unique situation of five closely related alphaherpesviruses revealed the importance of a high degree of genetic relatedness and similar parental virus growth kinetics for successful interspecific recombination.

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“…In addition, Chlamydophila abortus was recently detected by polymerase chain reaction from a mummified fetus from a healthy roe deer from our study area . Antibodies to BHV-1 also were not detected, and although serologic cross-reactions can occur among alphaherpesviruses (Keuser et al, 2004), we cannot discount the possible presence of other herpesviruses in these populations.…”

mentioning

confidence: 97%

Serosurvey of Roe Deer, Chamois and Domestic Sheep in the Central Italian Alps

Gaffuri

Giacometti²,

Tranquillo

et al. 2006

Journal of Wildlife Diseases

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ABSTRACT:Roe deer (Capreolus capreolus), chamois (Rupicapra rupricapra rupicapra), and domestic sheep in the Orobie Alps, Italy, were serologically tested for antibodies to selected pathogens that may be transmitted across species. Antibodies against Brucella spp. and bovine herpesvirus 1 (roe deer and chamois only) were not detected in any species. In roe deer, antibodies were detected against Toxoplasma gondii (13%) and Neospora caninum (3%). Chamois tested positive for antibodies to T. gondii (5%), N. caninum (21%), bovine respiratory syncytial virus (BRSV) (41%), bovine parainfluenza type-3 virus (17%), pestiviruses (18%), and Mycoplasma conjunctivae (17%). In the sheep, particularly high antibody prevalence rates were found for T. gondii (78%), Chlamydophila spp. (20%), pestiviruses (90%), BRSV (82%), and M. conjunctivae (81%).

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Improved Antigenic Methods for Differential Diagnosis of Bovine, Caprine, and Cervine Alphaherpesviruses Related to Bovine Herpesvirus 1

Cited by 32 publications

References 53 publications

Ruminant alphaherpesviruses related to bovine herpesvirus 1

Ruminant alphaherpesviruses related to bovine herpesvirus 1

Interspecific Recombination between Two Ruminant Alphaherpesviruses, Bovine Herpesviruses 1 and 5

Serosurvey of Roe Deer, Chamois and Domestic Sheep in the Central Italian Alps

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