Improved Antitumoral Activity of Extracts Derived from Cultured &lt;i&gt;Penicillus dumetosus&lt;/i&gt;

Moo‐Puc, Rosa; Robledo, Daniel; Freile, Yolanda

doi:10.4314/tjpr.v10i2.66561

Cited by 8 publications

(3 citation statements)

References 22 publications

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“…The cytotoxic and antiproliferative activity of several green, brown and red seaweed extracts appear to be related to their content of lipophilic compounds, phenols and lectins, respectively (Moo-Puc et al 2009); however, variations in lipid content and composition (i.e., fatty acids) did not explained the antiproliferative activity assessed against several cancer cell lines in cultured green seaweeds Penicillus dumetosus (Moo-Puc et al 2011b) and Udotea flavelum (Moo-Puc et al 2011a). Moreover, flavonoids and to a lesser extent phenolic compounds, contained in brown and red seaweeds mainly extracted with organic solvents, exerted a higher toxicity and growth cell inhibition in lung adenocarcinoma (A549) and osteosarcoma (MG-63) than in colon (HCT-15) and prostate (PC-3) cancer cells (Murugan & Iyer 2014).…”

Section: Discussionmentioning

confidence: 99%

Antioxidant, antimutagenic and antiproliferative activities in selected seaweed species from Sinaloa, Mexico

Osuna-Ruíz

López-Saiz

Burgos‐Hernández

et al. 2016

Pharmaceutical Biology

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Context Seaweeds from the Mexican Pacific Ocean have not been evaluated as a source of chemoprotectants. Objective The objective of this study is to evaluate chemopreventive activities of the seaweeds Phaephyceae - Padina durvillaei (Dictyotaceae) - Rodhophyceae - Spyridia filamentosa (Spyridiaceae), Gracilaria vermiculophylla (Gracilariaceae) - and Chlorophyceae - Ulva expansa (Ulvaceae), Codium isabelae (Codiaceae), Rhizoclonium riparium (Cladophoraceae) and Caulerpa sertularioides (Caulerpaceae). Materials and methods Methanol, acetone and hexane seaweed extracts were assessed at 30 and 3 mg/mL on antioxidant capacity (DPPH and ABTS assays), 0.003-3.0 mg/plate on antimutagenic activity against AFB1 using Salmonella typhimurium TA98 and TA100 tester strains in Ames test, and 12.5 to 100 μg/mL on antiproliferative activity on Murine B-cell lymphoma. Phenols, flavonoids and pigments content were also assessed as antioxidant compounds. Results Extraction yield was higher in methanol than in acetone and hexane extracts (6.4, 2.7 and 1.4% dw). Antioxidant capacity was higher in brown and green than in red seaweed species, particularly in P. durvillaei extracted in acetone (EC50 value= 16.9 and 1.56 mg/mL for DPPH and ABTS). Flavonoids and chlorophylls were identified as mainly antioxidant components; particularly in hexane extracts, which were correlated with the antioxidant capacity. Highest mutagenesis inhibition (> 40%) occurred in R. riparium at the lowest concentration assayed (0.003 mg/plate), while highest antiproliferative inhibition (37 and 72% for 12.5 and 25 μg/mL) occurred in C. sertularioides. Discussion and conclusion Flavonoids and chlorophylls explained the chemopreventive activities assessed in S. filamentosa, R. riparium and C. sertularioides. These seaweeds have a high potential as a source of novel chemoprotectants.

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Section: Discussionmentioning

confidence: 99%

Antioxidant, antimutagenic and antiproliferative activities in selected seaweed species from Sinaloa, Mexico

Osuna-Ruíz

López-Saiz

Burgos‐Hernández

et al. 2016

Pharmaceutical Biology

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“…Other uses on seaweeds of the coasts de Yucatan and Quintana Roo are Antileishmanial properties ( Freile-Pelegrin et al, 2008 ), anti-trichomonal activity ( Moo-puc et al, 2008 ), antioxidant activities ( Zubia et al, 2014 ), antitrypanosomal activity ( León-Denizet al, 2009 ), source of antiprotozoal compounds ( Cantillo-Ciau et al, 2010 ), antitumoral activity ( Moo-Puc et al, 2009 , Moo-Puc et al, 2011a , Moo-Puc et al, 2011b ) and hepatoprotective effect of the fucoidan, a sulfated polysaccharide isolated from algae ( Chale-Dzul et al, 2015 ).…”

Section: Introductionmentioning

confidence: 99%

Antimicrobial activity of some macroalgae of the Veracruzano Reef System (SAV), Mexico

Avila-Romero

García-Bores

Garduño-Solorzano

et al. 2023

Saudi Journal of Biological Sciences

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“…Similarly, Spyridia filamentosa , a red alga cultured at different light irradiances, had contrasting antibiotic activities that were strongly influenced by irradiance level [ 7 ]. Most recently, extracts obtained from Penicillus dumetosus cultured at different light irradiances displayed varying antiproliferative activity against diverse cancer cell lines [ 8 ]. The feasibility of algal cultivation can help to induce adaptations that can be measured through metabolite synthesis or biological activity.…”

Section: Introductionmentioning

confidence: 99%

Enhanced Antitumoral Activity of Extracts Derived from Cultured Udotea flabellum (Chlorophyta)

Moo-Puc

Robledo

Freile‐Pelegrín

2011

Evidence-Based Complementary and Alternative Medicine

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Very few studies have been performed to evaluate the effect of culture conditions on the production or activity of active metabolites in algae. Previous studies suggest that the synthesis of bioactive compounds is strongly influenced by irradiance level. To investigate whether the antiproliferative activity of Udotea flabellum extracts is modified after cultivation, this green alga was cultured under four photon flux densities (PFD) for 30 days. After 10, 20, and 30 days, algae were extracted with dichloromethane: methanol and screened for antiproliferative activity against four human cancer cell lines (laryngeal—Hep-2, cervix—HeLa, cervix squamous—SiHa and nasopharynx—KB) by SRB assay. Lipid and phenol content were evaluated by standardized methods on algae organic extracts. After 10 days of cultivation, organic U. flabellum extracts showed a significant increase in antiproliferative activity on Hela and SiHa cells when compared to noncultured algae extracts. Extracts obtained after 10 and 20 days of culture were active on KB and Hep-2 cells. Total phenol and polyunsaturated fatty acid content in organic extracts changed with cultivation time but not by irradiance treatment. Extracts from U. flabellum obtained after 10 and 20 days of culture have been selected for fractionation and isolation of active compounds.

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Improved Antitumoral Activity of Extracts Derived from Cultured <i>Penicillus dumetosus</i>

Cited by 8 publications

References 22 publications

Antioxidant, antimutagenic and antiproliferative activities in selected seaweed species from Sinaloa, Mexico

Antioxidant, antimutagenic and antiproliferative activities in selected seaweed species from Sinaloa, Mexico

Antimicrobial activity of some macroalgae of the Veracruzano Reef System (SAV), Mexico

Enhanced Antitumoral Activity of Extracts Derived from Cultured Udotea flabellum (Chlorophyta)

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