Seismic compression is the accrual of contractive volumetric strain in unsaturated or partially saturated sandy soils during earthquake shaking and has caused significant distress to overlying and nearby structures. The phenomenon can be well characterized by load-dependent, interaction macro-level fatigue theories. Toward this end, the Byrne cyclic shear-volumetric strain coupling model is expanded and calibrated for evaluating seismic compression for several soil types. In addition, the model was transformed to allow it to be implemented in a “simplified” manner, in addition to the original “non-simplified” formulation. Both implementation approaches are used to analyze a site in Japan impacted by the 2007, Mw6.6 Niigata-ken Chuetsu-oki earthquake. The results from the analyses are in general accord with the post-earthquake field observations and highlight the sensitivity of predicted magnitude of the seismic compression to the input variables used and modeling assumptions (e.g. relative density of the soil, magnitude of the volumetric threshold strain, orientation of the ground motions, settlement of soils below the ground water table, and accounting for multidirectional shaking). Although additional studies are needed to further validate the findings presented herein, estimation of relative density and threshold shear strain of the soil and ground motion orientation individually have moderate-to-significant influence on the computed magnitude of seismic compression, but they have a significant influence when taken in combination. Also, the seismic compression models can seemingly be used to predict the settlement in fully saturated sand when the excess pore water pressures are limited. Finally, accounting for multidirectional shaking has a significant influence on the computed magnitude of seismic compression.