Improved Aqueous Solubility of Crystalline Astaxanthin (3,3′‐dihydroxy‐β, β‐carotene‐4,4′‐dione) by Captisol® (Sulfobutyl Ether β‐Cyclodextrin)

Lockwood, Samuel F.; O’Malley, Sean; Mosher, Gerold L.

doi:10.1002/jps.10359

Cited by 87 publications

(52 citation statements)

References 15 publications

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“…Astaxanthin is a naturally occurring carotenoid pigment that is commonly used in salmonid feed to improve the colour appearance of the flesh. The pigment is water insoluble and usually deposited in the intramuscular fat tissue (LOOKWOOD et al, 2003). It could be suggested that in the older trout the longer astaxanthin intake and in the older as well as the (young and old) diploid trout the higher fat concentration in the fillets (Tab.…”

Section: Resultsmentioning

confidence: 99%

Flesh characteristics of pan-size triploid and diploid rainbow trout (<i>Oncorhynchus mykiss</i>) reared in a commercial fish farm

et al. 2008

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Flesh characteristics of pan-size triploid and diploid rainbow trout (Oncorhynchus mykiss) reared in a commercial fish farm AbstractSexual maturation of rainbow trout during production has a negative effect on the slaughter yields and flesh quality. Induction of triploidy is a method to prevent the development of fertile trout. In many investigations sexually mature triploid and diploid rainbow trout had been compared. In the present study the slaughter characteristics and flesh quality of female immature diploid and triploid rainbow trout reared up to 66 and 75 weeks (pan-size-format) were compared. Considering the age the old fish had significantly higher body and fillet weights accompanied with larger muscle fibres. The fillets of the old trout were brighter and redder, had a reduced water-holding capacity (WHC) and contained more fat and protein. With regard to the ploidy status the triploid trout had higher body and fillet weights and larger muscle fibres. The fillets of the triploid fish were brighter, had a reduced WHC and lower fat contents. With regard to the age-ploidy status interaction the young and old triploid trout had better growth characteristics but the WHC and the fillet fat concentration was reduced in these animals. The colour values were inconsistent. The pH and electrical conductivity values indicated no higher pre-or peri-mortal stress and/or different stress susceptibility of the investigated young as well as old triploid and diploid trout. In conclusion, it could be suggested that induction of triploidy positively influences body and fillet development mainly by muscle fibre hypertrophy, but the triploid fillets showed slightly worse flesh characteristics (Brightness, WHC).

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Section: Resultsmentioning

confidence: 99%

Flesh characteristics of pan-size triploid and diploid rainbow trout (<i>Oncorhynchus mykiss</i>) reared in a commercial fish farm

et al. 2008

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“…The combined extracts were evaporated to dryness under a stream of nitrogen gas. The dry extract was then reconstituted with methanol in required volumes to attain acceptable absorbance values at 446 nm [4]. A comparison between the test solutions and the external standard curve (range 0.26-4.0 lg/mL) established the amount of LUT in the test solutions.…”

Section: Phase Solubility Studymentioning

confidence: 99%

Preparation and characterization of spray dried complexes of lutein with cyclodextrins

Nalawade

Anuradha

2015

J Incl Phenom Macrocycl Chem

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Lutein (LUT) is one of the most important carotenoid and; the most prominent being its antioxidant activity. However, its use is limited due to poor solubility and instability under adverse conditions. An attempt is made to increase the solubility and hence bioavailability of LUT using various cyclodextrins viz., betacyclodextrin (bCD), hydroxypropyl betacyclodextrin (HP-bCD) and methyl betacyclodextrin (M-bCD). Physical mixtures and spray dried inclusion complexes were prepared and characterized using spectroscopic techniques, DSC and XRD studies. From the phase solubility and dissolution studies it was found that, M-bCD significantly improved the solubility of LUT. These complexes were further subjected to in vitro anti-proliferative activity in order to validate results obtained from solubility studies. The biological results were in congruence with the results of solubility studies. Spray dried complex of LUT:M-bCD showed significant percent growth inhibition as compared to other two complexes and LUT alone. Molecular modeling studies established the hostguest stoichiometry with the lowest energy to be 2:1, with the two hexatomic rings of a LUT molecule occupying the two M-bCD cavities. The present study forms the basis for the development of oral formulations of LUT with significantly improved solubility and bioavailability.

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“…In particular, SBE-b-CyD is one of the most popular bCyD derivatives used as a pharmaceutical excipient [15][16][17][18][19], which provides an extended hydrophobic cavity and an extremely hydrophilic exterior surface in comparison to bCyD. The SBE groups variably substitute at the 2-, 3-, and 6-positions of the total 21 hydroxyl groups of b-CyD [20][21][22].…”

Section: Introductionmentioning

confidence: 99%

Isoflavone aglycons-sulfobutyl ether-β-cyclodextrin inclusion complexes: in solution and solid state studies

Stancanelli

Venuti

Arigò

et al. 2015

J Incl Phenom Macrocycl Chem

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The effect of a polyanionic variably substituted sulfobutyl ether-b-cyclodextrin (SBE-b-CyD), complexation on the UV absorption of genistein (Gen) and daidzein (Dai) was studied in pure water. A phase solubility study was performed, according to the method reported by Higuchi and Connors, to evaluate the changes of isoflavones in the complexation state and type-A L solubility diagrams for both isoflavones were obtained suggesting that they form complexes with 1:1 molar ratio. These results were confirmed by Job's plot method. Complexation strongly increases the water solubility of isoflavones. The in vitro dissolution of isoflavones entrapped into SBE-b-CyD significantly surpassed that of the free isoflavones (over 90 % of the loaded Gen and Dai dissolved in 15 and 30 min, respectively). Finally, 1:1 molar ratio solid complexes were prepared by the kneading method and characterized in solid state by FTIR-ATR spectroscopy, with particular regard to O-H and C=O stretching vibrations, achieving structural information on the modifications induced by complexation on the H-bond scheme, also by applying band decomposition and curve-fit.

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Improved Aqueous Solubility of Crystalline Astaxanthin (3,3′‐dihydroxy‐β, β‐carotene‐4,4′‐dione) by Captisol® (Sulfobutyl Ether β‐Cyclodextrin)

Cited by 87 publications

References 15 publications

Flesh characteristics of pan-size triploid and diploid rainbow trout (<i>Oncorhynchus mykiss</i>) reared in a commercial fish farm

Flesh characteristics of pan-size triploid and diploid rainbow trout (<i>Oncorhynchus mykiss</i>) reared in a commercial fish farm

Preparation and characterization of spray dried complexes of lutein with cyclodextrins

Isoflavone aglycons-sulfobutyl ether-β-cyclodextrin inclusion complexes: in solution and solid state studies

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Improved Aqueous Solubility of Crystalline Astaxanthin (3,3′‐dihydroxy‐β, β‐carotene‐4,4′‐dione) by Captisol® (Sulfobutyl Ether β‐Cyclodextrin)

Cited by 87 publications

References 15 publications

Flesh characteristics of pan-size triploid and diploid rainbow trout (&lt;i&gt;Oncorhynchus mykiss&lt;/i&gt;) reared in a commercial fish farm

Flesh characteristics of pan-size triploid and diploid rainbow trout (&lt;i&gt;Oncorhynchus mykiss&lt;/i&gt;) reared in a commercial fish farm

Preparation and characterization of spray dried complexes of lutein with cyclodextrins

Isoflavone aglycons-sulfobutyl ether-β-cyclodextrin inclusion complexes: in solution and solid state studies

Contact Info

Product

Resources

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Flesh characteristics of pan-size triploid and diploid rainbow trout (<i>Oncorhynchus mykiss</i>) reared in a commercial fish farm

Flesh characteristics of pan-size triploid and diploid rainbow trout (<i>Oncorhynchus mykiss</i>) reared in a commercial fish farm