Improved assessment of body cell mass by segmental bioimpedance analysis in malnourished subjects and acromegaly

Pirlich, Matthias; Schütz, Tatjana; Ockenga, Johann; Biering, H.; Gerl, H; Schmidt, Bernd; Ertl, S; Plauth, Mathias; Lochs, Herbert

doi:10.1054/clnu.2002.0617

Cited by 23 publications

(12 citation statements)

References 33 publications

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“…Another possibility is that combinations of segmental measurements may improve prediction of whole-body components in some conditions. Pirlich et al (2003) investigated the value of segmental BIA for body cell mass (BCM) estimation in malnourished subjects and acromegaly.…”

Section: Discussionmentioning

confidence: 99%

New bioimpedance analysis system: improved phenotyping with whole-body analysis

et al. 2004

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Objective: Bioimpedance analysis (BIA) is a potential field and clinical method for evaluating skeletal muscle mass (SM) and %fat. A new BIA system has 8-(two on each hand and foot) rather than 4-contact electrodes allowing for rapid 'whole-body' and regional body composition evaluation. Design: This study evaluated the 50 kHz BC-418 8-contact electrode and TBF-310 4-contact electrode foot-foot BIA systems (Tanita Corp., Tokyo, Japan). Subjects: There were 40 subject evaluations in males (n ¼ 20) and females (n ¼ 20) ranging in age from 6 to 64 y. BIA was evaluated in each subject and compared to reference lean soft-tissue (LST) and %fat estimates in the appendages and remainder (trunk þ head) provided by dual-energy X-ray absorptiometry (DXA). Appendicular LST (ALST) estimates from both BIA and DXA were used to derive total body SM mass. Results: The highest correlation between total body LST by DXA and impedance index (Ht 2 /Z) by BC-418 was for the foot-hand segments (r ¼ 0.986; left side only) compared to the arm (r ¼ 0.970-0.979) and leg segments (r ¼ 0.942-0.957)(all Po0.001).The within-and between-day coefficient of variation for %fat and ALST evaluated in five subjects was o1% and B1-3.7%, respectively. The correlations between 8-electrode predicted and DXA appendicular (arms, legs, total) and trunk þ head LST were strong and highly significant (all rX0.95, Po0.001) and group means did not differ across methods. Skeletal muscle mass calculated (Kim equation) from total ALST by DXA (X7s.d.)(23.779.7 kg) was not significantly different and highly correlated with BC-418 estimates (25.279.6 kg; r ¼ 0.96, Po0.001). There was a good correlation between total body %fat by 8-electrode BIA vs DXA (r ¼ 0.87, Po0.001) that exceeded the corresponding association with 4-electrode BIA (r ¼ 0.82, Po0.001). Group mean segmental %fat estimates from BC-418 did not differ significantly from corresponding DXA estimates. No betweenmethod bias was detected in the whole body, ALST, and skeletal muscle analyses. Conclusions:The new 8-electrode BIA system offers an important new opportunity of evaluating SM in research and clinical settings. The additional electrodes of the new BIA system also improve the association with DXA %fat estimates over those provided by the conventional foot-foot BIA.

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Section: Discussionmentioning

confidence: 99%

New bioimpedance analysis system: improved phenotyping with whole-body analysis

et al. 2004

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“…Data on lean body mass using total-body potassium (TBK) measurements, a more reliable method for assessing body cell mass, have been conflicting in acromegaly. Pirlich et al [35] evaluated body cell mass in 18 subjects with acromegaly and did not detect differences in TBK and body cell mass versus controls. In a study by Landin et al [36] of nine acromegalic patients, surgical resection of a GH-secreting adenoma was associated with a reduction in body cell mass as measured by TBK.…”

Section: Lean Body Massmentioning

confidence: 98%

Alterations in body composition in acromegaly

Katznelson

2008

Pituitary

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Acromegaly is a condition characterized by growth hormone (GH) and insulin-like growth factor-1 (IGF-1) hypersecretion, and is associated with boney overgrowth, and soft tissue abnormalities due to anabolic, lipolytic, and sodium retaining actions of GH. GH and IGF-1 excess is associated with alterations in body composition, including an increase in body water and lean body mass, and a reduction in body fat. Achievement of biochemical control of the disease results in a reduction in body water and fat-free mass, and an increase in body fat. BMD is generally increased in acromegaly, though the anabolic effect of GH excess on bone is reduced, if not negated, by the presence of hypogonadism, particularly with regard to the trabecular compartment. Further studies are necessary to determine the effect of long-term biochemical control on bone density in subjects with acromegaly.

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“…Only one study published segmental Xc values at 100 kHz (Bracco et al 1996) and no study used 5 kHz. Data on segmental PA at 50 kHz were not included in the table because there were only three studies present (Zillikens et al 1992;Bracco et al 1996;Pirlich et al 2003). Most studies used a technique comparable to T1 of the present study.…”

Section: Comparisons With Other Studies By Techniquementioning

confidence: 99%

“…In contrast, electrode sites on the hip varied. Some authors (present study, Bracco et al 1996;Pirlich et al 2003) applied the definition of Fuller and Elia (1989), where the sensing electrode is situated anterior to the iliac crest. Others Baumgartner et al 1989;Zillikens et al 1992;Woodrow et al 1996Woodrow et al , 1997Zhu et al 1999Zhu et al , 2000 followed the definition of Chumlea et al (1988), where the sensing electrode is located on the level of the gluteal crease.…”

Section: Comparisons With Other Studies By Techniquementioning

confidence: 99%

Comparison of three segmental multifrequency bioelectrical impedance techniques in healthy adults

Mally

Dittmar

2012

Annals of Human Biology

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Differences exist between the three techniques which are primarily caused by inconsistent current pathways. A comparison with literature data showed that, in addition, subject's posture during measurement, electrode contact and electrode site may lead to inconsistent resistance and reactance values. This makes comparisons between different populations difficult. Therefore, this study recommends generally using the T2 technique which is standardized, easy to use and, thereby, well suited for field studies in large population groups.

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Improved assessment of body cell mass by segmental bioimpedance analysis in malnourished subjects and acromegaly

Cited by 23 publications

References 33 publications

New bioimpedance analysis system: improved phenotyping with whole-body analysis

New bioimpedance analysis system: improved phenotyping with whole-body analysis

Alterations in body composition in acromegaly

Comparison of three segmental multifrequency bioelectrical impedance techniques in healthy adults

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