Improved Biocompatibility of Titanium&amp;ndash;Zirconium (Ti&amp;ndash;Zr) Alloy: Tissue Reaction and Sensitization to Ti&amp;ndash;Zr Alloy Compared with Pure Ti and Zr in Rat Implantation Study

Ikarashi, Yoshiaki; Toyoda, Kazuhiro; Kobayashi, Equo; Doi, Hisashi; Yoneyama, Takayuki; Hamanaka, Hitoshi; Tsuchiya, Toshie

doi:10.2320/matertrans.46.2260

Cited by 96 publications

(28 citation statements)

References 41 publications

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“…However, an additional 3 were added as they were discovered during the analysis of the search retrieved papers. From the 12 articles that met the criteria, four were dedicated to in vitro and/or mechanical studies of TiZr [17,19,29,35], five articles investigated the performance of TiZr implants in animals [21,36,37,38,39], while three articles analyzed clinical outcomes of TiZr dental implants [6,40,41]. The results of these studies are summarized in Table 1, Table 2 and Table 3.…”

Section: Resultsmentioning

confidence: 99%

“…Early work by Ikarashi et al investigating the performance of TiZr in animals further illustrated its biocompatibility by comparing TiZr, cpTi and chromium (Cr) plates implanted in rats, with the finding that TiZr performed better, even, than pure Ti or Cr [21]. Prior to that, in 1987, a study by Shibata et al found that the sintering of larger particle sizes in the formation porous TiZr (40% Zr) implants led to a higher bone ingrowth, when implanted in rabbits, and higher bonding strength as determined by push-out tests [38].…”

Section: Discussionmentioning

confidence: 99%

“…In particular, alloys containing zirconium have demonstrated both the required mechanical strength and a high resistance to corrosion in biological fluids [13,17,19]. The biocompatibility of TiZr-based alloys indicates an improvement even over cpTi, the gold standard [20,21]. …”

Section: Introductionmentioning

confidence: 99%

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A Review of Titanium Zirconium (TiZr) Alloys for Use in Endosseous Dental Implants

2012

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Dental implants made from binary titanium-zirconium (TiZr) alloys have shown promise as a high strength, yet biocompatible alternative to pure titanium, particularly for applications requiring small diameter implants. The aim of this review is to summarize existing literature reporting on the use of binary TiZr alloys for endosseous dental implant applications as tested in vitro, in animals and clinically. And furthermore to show that TiZr is “at least as good as” pure titanium in terms of biocompatibility and osseointergration. From the twelve papers that met the inclusion criteria, the current literature confirms that TiZr alloys produce small diameter implants with a strength up to 40% higher than conventional, cold-worked, grade IV titanium implants, and with a corrosion resistance and biocompatibility that is at least as good as pure titanium. The surface structure of TiZr is compatible with established surface treatments proven to aid in the osseointegration of titanium implants. Furthermore, binary TiZr alloys have been shown to achieve good osseointegration and high success rates both in animal and in clinical studies.

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Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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A Review of Titanium Zirconium (TiZr) Alloys for Use in Endosseous Dental Implants

2012

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“…Moreover, other cations (e.g., Ag, Cu, Zn and Ce) might present additional therapeutic effects, e.g., angiogenesis that is essential for cicatrize process, and antimicrobial properties [18,37]. According to Ikarashi et al [38], titanium-zirconium (Ti-Zr) alloy-implants exhibit the best biocompatibility, improved properties (in respect to pure Ti) and a low level of fretting corrosion. Nowadays, toxicological effects, related to antibacterial properties of noble metals' ions, such as Ag + and Au + , which might be released by titanium alloys, have been a growing matter of concern [39].…”

Section: Toxicity Of Titanium and Its Alloysmentioning

confidence: 99%

Are Titania Photocatalysts and Titanium Implants Safe? Review on the Toxicity of Titanium Compounds

et al. 2020

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Titanium and its compounds are broadly used in both industrial and domestic products, including jet engines, missiles, prostheses, implants, pigments, cosmetics, food, and photocatalysts for environmental purification and solar energy conversion. Although titanium/titania-containing materials are usually safe for human, animals and environment, increasing concerns on their negative impacts have been postulated. Accordingly, this review covers current knowledge on the toxicity of titania and titanium, in which the behaviour, bioavailability, mechanisms of action, and environmental impacts have been discussed in detail, considering both light and dark conditions. Consequently, the following conclusions have been drawn: (i) titania photocatalysts rarely cause health and environmental problems; (ii) despite the lack of proof, the possible carcinogenicity of titania powders to humans is considered by some authorities; (iii) titanium alloys, commonly applied as implant materials, possess a relatively low health risk; (iv) titania microparticles are less toxic than nanoparticles, independent of the means of exposure; (v) excessive accumulation of titanium in the environment cannot be ignored; (vi) titanium/titania-containing products should be clearly marked with health warning labels, especially for pregnant women and young children; (vi) a key knowledge gap is the lack of comprehensive data about the environmental content and the influence of titania/titanium on biodiversity and the ecological functioning of terrestrial and aquatic ecosystems.

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“…Therefore, Zr coating is a useful technique to inhibit the assimilation of Ti alloys with bone. Another approach is the development of a Zr-based alloy, which is being actively studied in Japan (Kobayashi et al 1995;Ikarashi et al 2005).…”

Section: Inhibition Of Assimilationmentioning

confidence: 99%

An overview of biofunctionalization of metals in Japan

Hanawa

2009

J. R. Soc. Interface.

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Surface modification is an important and predominant technique for obtaining biofunction and biocompatibility in metals for biomedical use. The surface modification technique is a process that changes the surface composition, structure and morphology of a material, leaving the bulk mechanical properties intact. A tremendous number of surface modification techniques using dry and wet processes to improve the hard tissue compatibility of titanium have been developed. Some are now commercially available. Most of these processes have been developed by Japanese institutions since the 1990s. A second approach is the immobilization of biofunctional molecules to the metal surface to control the adsorption of proteins and adhesion of cells, platelets and bacteria. The immobilization of poly(ethylene glycol) to a metal surface with electrodeposition and its effect on biofunction are reviewed. The creation of a metal-polymer composite is another way to obtain metal-based biofunctional materials. The relationship between the shear bonding strength and the chemical structure at the bonding interface of a Ti-segmentated polyurethane composite through a silane coupling agent is explained.

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Improved Biocompatibility of Titanium–Zirconium (Ti–Zr) Alloy: Tissue Reaction and Sensitization to Ti–Zr Alloy Compared with Pure Ti and Zr in Rat Implantation Study

Cited by 96 publications

References 41 publications

A Review of Titanium Zirconium (TiZr) Alloys for Use in Endosseous Dental Implants

A Review of Titanium Zirconium (TiZr) Alloys for Use in Endosseous Dental Implants

Are Titania Photocatalysts and Titanium Implants Safe? Review on the Toxicity of Titanium Compounds

An overview of biofunctionalization of metals in Japan

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