Improved brightness of multiarylpyrroles in the near-infrared region via coordination-induced supramolecular system

Multifunctional Self-Assembled Nanoplatform with AIEgen and Rapamycin-Mediated Tumor Microenvironment Remodeling via mTOR Axis to Enhance Photodynamic Therapy

“…Due to the existence of sulfonates and quaternary ammonium cations, the synthesized AIEgen have amphiphilic properties, and promote self-assembly to form carrier-free nanoparticles. The thiophene part, as the junction of the π bridge into the molecular structure, provides superior flatness and higher D−π–A strength for the electron-rich ion π-connected AIEgen, which is conducive to intramolecular electron transfer and reduces the energy level difference (Δ E st ) between singlet and triplet states and improves the production of type I ROS. ,, According to a report by Professor Zhu’s team, a thiophene structure with epoxy ethyl attachment was selected as the π bridges are beneficial for promoting the self-assembly of AIEgen into uniform spherical nanoparticles in water, which is more conducive to tumor-targeted biological imaging performance …”

“…The thiophene part, as the junction of the π bridge into the molecular structure, provides superior flatness and higher D−π−A strength for the electron-rich ion π-connected AIEgen, which is conducive to intramolecular electron transfer and reduces the energy level difference (ΔE st ) between singlet and triplet states and improves the production of type I ROS. 12,36,12 According to a report by Professor Zhu's team, a thiophene structure with epoxy ethyl attachment was selected as the π bridges are beneficial for promoting the self-assembly of AIEgen into uniform spherical nanoparticles in water, which is more conducive to tumor-targeted biological imaging performance. 37 As illustrated in Scheme 2, zwitterionic compounds TNTP with a D−π−A structure was facilely synthesized through fewstep reactions.…”