Improved characterisation of focal liver tumours: dynamic power Doppler imaging using NC100100 echo-enhancer

Ramnarine, Kumar V.; Kyriakopoulou, Konstantina; Gordon, Paul B.; McDicken, Norman; McArdle, C. S.; Leen, Edward

doi:10.1016/s0929-8266(00)00074-4

Cited by 27 publications

(17 citation statements)

References 19 publications

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“…The enhancement patterns of dynamic sonography corresponded well to the findings in the dynamic CT [26] as well as in contrast-enhanced ultrasound [5,8,9,22,34]. For example, characteristic findings such as the homogeneous arterial contrast enhancement of the FNH and the peripheral contrast uptake of the hemangiomas could clearly be visualized.…”

Section: Discussionsupporting

confidence: 73%

Quantitative dynamic contrast-enhanced sonography of hepatic tumors

et al. 2004

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Liver tumors are defined using quantitative dynamic contrast-enhanced ultrasound compared to histological diagnosis, respectively, long-term follow-ups. Forty-two focal liver lesions in 39 patients were examined by contrast harmonic imaging over a period of 2 min after bolus injection of 10-ml galactose-based contrast agent. Vascular enhancement was quantified by using a dedicated software that allowed us to place representative regions of interest (ROI) in the center of the lesion, in the complete lesion, in regular liver parenchyma and in representative liver vessels (artery, vein and portal vein). Peak enhancement was judged to be either in the arterial, portal venous or in the late phase of liver perfusion. The lesion was described as hypovascular, isovascular and hypervascular compared to liver parenchyma. Contrast uptake was described as centrifugal or centripetal and peripheral or homogenous, respectively. Characterization of the lesions was performed unenhanced and after contrast by four independent specialists unaware of histology. Diagnosis of malignancy was evaluated by using a receiver operating characteristic (ROC) analysis, also overall accuracy, average sensitivity, specificity and negative and positive predictive values were calculated. Interobserver agreement was defined by the Kappa statistics. Histologic examination revealed 29 malignant [hepatocellular carcinoma (HCC), n=11; cholangiocellular carcinoma (CCC), n=1; lymphoma, n=1; metastases, n=16)] and 7 benign [hemangioma, n=1; focal nodular hyperplasia (FNH), n=4, adenoma, n=2)] lesions. Six benign lesions (hemangioma n=1; FNH n=5) were proved by long-term follow-up. ROC analysis regarding the diagnosis of malignancy showed values from 0.43 to 0.62 (mean 0.57) before and from 0.70 to 0.80 (mean 0.75) after contrast agent, respectively. The average values for sensitivity, specificity, accuracy and negative and positive predictive values were 66, 26, 62, 45 and 73% unenhanced and 83, 49, 73, 65 and 82% after contrast, respectively. The interobserver agreement was 0.54 and 0.65 for unenhanced and enhanced examinations, respectively. Quantitative dynamic contrast-enhanced sonography improves the diagnosis of malignancy in liver lesions.

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Section: Discussionsupporting

confidence: 73%

Quantitative dynamic contrast-enhanced sonography of hepatic tumors

et al. 2004

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“…A white "veil" corresponding to a wave of contrast destruction can be seen descending through the scan plane. Haemangiomas did not participate in this "veil"; hepatomas always participated in the "veil" whilst only the margin of colorectal metastases did [11,12] Tumour visualisation with echo contrast agents Primary and secondary neoplasms of the liver demonstrate wide variability in their vascularity, which is dependent to some extent upon the size and growth of the tumour. It is now generally accepted that when the tumour is small (about 1 mm) the main blood supply is via the portal vein.…”

Section: Recent Clinical Trials and New Perspectivesmentioning

confidence: 99%

The role of contrast-enhanced ultrasound in the characterisation of focal liver leasions

Leen

2001

Eur Radiol

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“…It provides persistent and stable enhancement during the post-vascular phase, as well as real-time fine vascular images during the vascular phase [10,11,12]. CEUS with sonazoid has been reported to be a useful method to predict macroscopic findings of HCC [13,14].…”

Section: Introductionmentioning

confidence: 99%

Comparison of Contrast-Enhanced Ultrasound and Gadolinium-Ethoxybenzyl-Diethylenetriamine Pentaacetic Acid-Enhanced MRI for the Diagnosis of Macroscopic Type of Hepatocellular Carcinoma

Inomata

Imai

Kogita

et al. 2016

Dig Dis

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Objective: We compared the efficacy of contrast-enhanced ultrasound sonography (CEUS) with sonazoid and gadolinium-ethoxybenzyl-diethylenetriamine pentaacetic acid (Gd-EOB-DTPA)-enhanced MRI for the assessment of macroscopic classification of nodular hepatocellular carcinoma (HCC). Methods: Seventy-seven consecutive patients with 79 surgically resected HCCs who underwent both preoperative CEUS and Gd-EOB-DTPA-enhanced MRI were enrolled in this retrospective study. Based on the macroscopic diagnosis of resected specimens, nodules were categorized into the simple nodular (SN) and non-SN type HCC. Two hepatologists independently assessed image datasets of the post-vascular phase of CEUS and hepatobiliary phase of Gd-EOB-DTPA-enhanced MRI to compare their diagnostic performance. Results: Gd-EOB-DTPA-enhanced MRI enabled the evaluation of macroscopic classification in a significantly larger number of nodules than CEUS (78/79 (98.7%) vs. 70/79 (88.6%), p < 0.05). Of 70 nodules that could be evaluated by both modalities, 41 and 29 nodules were pathologically categorized as SN and non-SN, respectively. The areas under the receiver operating characteristic curve (AUC) for non-SN did not differ between CEUS and Gd-EOB-DTPA-enhanced MRI (reader 1: 0.748 for CEUS, 0.808 for MRI; reader 2: 0.759 for CEUS, 0.787 for MRI). The AUC of combined CEUS and Gd-EOB-DTPA-enhanced MRI for SN HCC was 0.855 (reader 1) and 0.824 (reader 2), indicating higher AUC values for the combined modalities. Conclusions: The diagnostic performance for macroscopic classification of nodular HCC of CEUS was comparable with that of Gd-EOB-DTPA-enhanced MRI, although some HCCs could not be evaluated by CEUS owing to lower detectability. The combination of the 2 modalities had a more accurate diagnostic performance.

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Improved characterisation of focal liver tumours: dynamic power Doppler imaging using NC100100 echo-enhancer

Cited by 27 publications

References 19 publications

Quantitative dynamic contrast-enhanced sonography of hepatic tumors

Quantitative dynamic contrast-enhanced sonography of hepatic tumors

The role of contrast-enhanced ultrasound in the characterisation of focal liver leasions

Comparison of Contrast-Enhanced Ultrasound and Gadolinium-Ethoxybenzyl-Diethylenetriamine Pentaacetic Acid-Enhanced MRI for the Diagnosis of Macroscopic Type of Hepatocellular Carcinoma

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