The genus Goniothalamus is belonging to the Annonaceae family, consists of ca. 2500 species and found in tropical Southeast Asia. The Goniothalamus essential oils were recognized to possess considerable biological activities with varied chemical composition. This article aims to overview the medicinal uses, chemical compositions, and biological activities of Malaysian Goniothalamus essential oils considered as a medicinal plants, widely used as traditional herbal medicines in the treatment of various diseases. The data were collected from the scientific electronic databases including SciFinder, Scopus, Elsevier, PubMed and Google Scholar. Ten Goniothalamus species have been reported for their essential oils and biological activities. It can be observed that the major components were α-cadinol, terpinen-4-ol, β-eudesmol, β-selinene, linalool, limonene, α-copaene, 1,8-cineole and β-cubebene. In addition, the selected chemical components from the bark, leaf and root oils were analysed using Principal Component Analysis (PCA) and Hierarchical Cluster Analysis (HCA) and were able to cluster in four groups based on relationships and chemical patterns in essential oils. This multivariate data analysis may be used for the identification and characterization of essential oils from different Goniothalamus species that are to be used as raw materials of traditional herbal products.