Improved Coagulation with Saline Solution Pretreatment during Radiofrequency Tumor Ablation in a Canine Model

Ahmed, Muneeb; Lobo, S. Melvyn; Weinstein, Joseph; Kruskal, Jonathan B.; Gazelle, G. Scott; Halpern, Elkan F.; Afzal, S. Karim; Lenkinski, Robert E.; Goldberg, S. Nahum

doi:10.1016/s1051-0443(07)61850-8

Cited by 85 publications

(43 citation statements)

References 38 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Our computer results suggest that delivering RF power by current pulses delays roll-off and creates larger coagulation zones. A possible way of ensuring this working condition would be to reduce tissue impedance, for instance, by saline infusion before heating [28].…”

Section: Comparison Between Current Pulses and Voltage Pulsesmentioning

confidence: 99%

Computer modelling of an impedance-controlled pulsing protocol for RF tumour ablation with a cooled electrode

Trujillo

Bon

Rivera

et al. 2016

International Journal of Hyperthermia

View full text Add to dashboard Cite

Purpose: To develop computer models to mimic the impedance-controlled pulsing protocol implemented in RF generators used for clinical practice of radiofrequency ablation (RFA), and to assess the appropriateness of the models by comparing the computer results with those obtained in previous experimental studies.Methods: A 12-minute RFA was modeled using a cooled electrode (17G, 3 cm tip) inserted in hepatic tissue. The short (transverse) diameter of the coagulation zone was assessed under in vivo (with blood perfusion and considering clamping) and ex vivo (at 21ºC) conditions.The computer results obtained by programming voltage pulses were compared with current pulses.Results: The differences between voltage and current pulses protocol were noticeable: using current instead of voltage allows larger coagulation zones to be created, due to the higher energy applied by current pulses. If voltage pulses are employed, the model can accurately predict number of roll-offs, although the waveform of the applied power is clearly not realistic. If current voltages are employed, the applied power waveform matches well with those reported experimentally, but there are significantly fewer roll-offs. Our computer results were overall into the ranges of experimental ones. Conclusions:The proposed models reproduce reasonably well the electrical-thermal performance and coagulation zone size obtained during an impedance-controlled pulsing protocol.

show abstract

Section: Comparison Between Current Pulses and Voltage Pulsesmentioning

confidence: 99%

Computer modelling of an impedance-controlled pulsing protocol for RF tumour ablation with a cooled electrode

Trujillo

Bon

Rivera

et al. 2016

International Journal of Hyperthermia

View full text Add to dashboard Cite

show abstract

“…Several working groups have reported on ex vivo experiments on livers, with different experimental setups, where saline solution was used as an additive to enhance the effectiveness of RFA [7,9,10,12,23,[25][26][27]. These studies have shown that the use of perfusion liquids has a positive effect on necrosis size.…”

Section: Discussionmentioning

confidence: 99%

“…Ahmed et al [25] succeeded in creating significantly larger lesions of up to 5.2 cm diameter by using highly concentrated saline solution (36% NaCl). However they did not provide exact data on the perfusion rate because of using internal cooled needle applicators.…”

Section: Discussionmentioning

confidence: 99%

“…However they did not provide exact data on the perfusion rate because of using internal cooled needle applicators. In this context Ahmed et al [25] did not analyze the effect of permanent wet perfusion during RFA. In contrast we used a wet needle system with variable perfusion rates to study the change of perfusion.…”

Section: Discussionmentioning

confidence: 99%

“…At first physiological saline solution or lower concentrated saline solutions were used to simulate physiological conditions. However, further studies using high osmolar saline solutions in a wet needle system should be conducted [25].…”

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Radiofrequency Ablation of Liver Tumors: How to Enlarge the Necrotic Zones?

Frieser

Haensler²,

Schaber³

et al. 2004

Eur Surg Res

View full text Add to dashboard Cite

In an attempt to increase necrotic zones in liver tissue by radiofrequency ablation fresh bovine liver was coagulated by means of a needle electrode continuously perfused with NaCl solution. Power output (60 W) and application time (15 min) were kept constant while the perfusion was varied in terms of saline concentration (0.9, 5.85 and 10%) and perfusion rate (40 or 80 ml/h). Our results showed that the use of higher osmolar saline solutions in radiofrequency ablation with perfused needle electrodes did not lead to significantly larger coagulation volumes. By contrast, increasing the perfusion rate produced significantly larger necrotic zones. Doubling the perfusion rate made it possible to reach higher temperatures (>60°C) within significantly shorter time.

show abstract

Effectivity of laser-induced thermotherapy: In vivo comparison of arterial microembolization and complete hepatic inflow occlusion

et al. 2005

View full text Add to dashboard Cite

show abstract

Improved Coagulation with Saline Solution Pretreatment during Radiofrequency Tumor Ablation in a Canine Model

Cited by 85 publications

References 38 publications

Computer modelling of an impedance-controlled pulsing protocol for RF tumour ablation with a cooled electrode

Computer modelling of an impedance-controlled pulsing protocol for RF tumour ablation with a cooled electrode

Radiofrequency Ablation of Liver Tumors: How to Enlarge the Necrotic Zones?

Effectivity of laser-induced thermotherapy: In vivo comparison of arterial microembolization and complete hepatic inflow occlusion

Contact Info

Product

Resources

About