2004
DOI: 10.1002/jbm.b.30051
|View full text |Cite
|
Sign up to set email alerts
|

Improved collagen bilayer dressing for the controlled release of drugs

Abstract: A novel bilayer dressing has been developed from bovine succinylated collagen. The dressing contains an antibiotic, Ciprofloxacin, for both immediate and time-regulated release for controlling the infection, as the infected open wounds need special care. The dressing consists of a sponge and a film, both prepared from succinylated bovine collagen. The sponge has a smooth surface on one side; its rough surface on the other side forms the bilayer system with the film. Both sponge and film act as an anionic reser… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
1

Citation Types

2
53
0

Year Published

2005
2005
2021
2021

Publication Types

Select...
6
2

Relationship

0
8

Authors

Journals

citations
Cited by 82 publications
(55 citation statements)
references
References 32 publications
2
53
0
Order By: Relevance
“…Vascular grafts sealed with albumin and gelatin have been shown to promote such interactions and therefore demonstrate a reduced burst release of antibiotics compared to uncoated grafts [11,12]. A wound dressing based on succinylated collagen, which behaves as an anion after swelling, has been shown to delay the release of the cationic drug ciprofloxacin via ionic interactions [17].…”
Section: Introductionmentioning
confidence: 99%
See 1 more Smart Citation
“…Vascular grafts sealed with albumin and gelatin have been shown to promote such interactions and therefore demonstrate a reduced burst release of antibiotics compared to uncoated grafts [11,12]. A wound dressing based on succinylated collagen, which behaves as an anion after swelling, has been shown to delay the release of the cationic drug ciprofloxacin via ionic interactions [17].…”
Section: Introductionmentioning
confidence: 99%
“…Hence, characteristic healing has been reported to take 3-7 weeks [14]. Common strategies that have been described in an attempt to overcome the problem of rapid drug release include the entrapment of the hydrophilic drug within a hydrophobic substance as a means to delay water penetration and outward drug diffusion [15,16], or enhancement of drug bonding to the carrying matrix [11,12,17]. The latter can be achieved either by selecting or modifying a matrix material to support the formation of covalent bonds, Van der Waals dispersion forces, hydrogen bonds, or ionic interactions between the drug and the matrix.…”
Section: Introductionmentioning
confidence: 99%
“…In addition, SPSC with increased negative charges acted as an anionic reservoir to hold the cationic drugs by ionic binding, which permitted only time-regulated release of drugs. 9) Meanwhile, the relative viscosity and intrinsic viscosity of SPSC became about 1.6-fold and 1.8-fold higher than those of PSC respectively, also because of the increase in negative charges of PSC and the hydrodynamic volume of the modified collagen.…”
mentioning
confidence: 96%
“…Proper chemical modification can be a good choice for overcoming this limitation of PSC. Succinylation has been widely used in soy protein modification in food industry 3,4) and in collagen modification in the biomedical field, such as time-regulated released drugs, 5) vascular prostheses, 6) and biomaterial carriers with a porous structure. 7) In order to apply succinylated collagen much more efficiently, it is of importance to study its physicochemical properties.…”
mentioning
confidence: 99%
“…The hydrophilic nature of soy protein enables relatively rapid water intake, leading to full swelling of the matrix within a few hours of immersion. Unfavorable more rapid drug release rates have been reported in the literature for other antibioticeluting systems [33]. Controlling the release of antibiotics from these systems is challenging due to the hydrophilic nature of both the drug and the host polymer.…”
Section: Gentamicin Release Profilementioning
confidence: 99%