Improved delivery of doxorubicin using rationally designed PEGylated platinum nanoparticles for the treatment of melanoma

Mukherjee, Sudip; Kotcherlakota, Rajesh; Haque, Shagufta; Bhattacharya, Debapriya; Kumar, Jerald Mahesh; Chakravarty, Sumana; Patra, Chitta Ranjan

doi:10.1016/j.msec.2019.110375

Cited by 76 publications

(51 citation statements)

References 48 publications

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“…Further investigation should be developed according to pharmaceutical perspective and it should be designed as in situ, preclinical, and clinical studies. It is needed to perform an evaluation on the effect on cell cycle and apoptosis as described in the literature [ 12 , 45 ].…”

Section: Discussionmentioning

confidence: 99%

Efficient Doxorubicin Loading to Isolated Dexosomes of Immature JAWSII Cells: Formulated and Characterized as the Bionanomaterial

et al. 2020

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Immature dendritic cells (IDc), ‘dexosomes’, are promising natural nanomaterials for cancer diagnose and therapy. Dexosomes were isolated purely from small-scale-up production by using t25-cell-culture flasks. Total RNA was measured as 1.43 ± 0.33 ng/106 cell. Despite the fact that they possessed a surface that is highly abundant in protein, this did not become a significant effect on the DOX loading amount. Ultrasonication was used for doxorubicin (DOX) loading into the IDc dexosomes. In accordance with the literature, three candidate DOX formulations were designed as IC50 values; dExoIII, 1.8 µg/mL, dExoII, 1.2 µg/mL, and dExoI, 0.6 µg/mL, respectively. Formulations were evaluated by MTT test against highly metastatic A549 (CCL-185; ATTC) cell line. Confocal images of unloaded (naïve) were obtained by CellMaskTM membrane staining before DOX loading. Although, dexosome membranes were highly durable subsequent to ultrasonication, it was observed that dexosomes could not be stable above 70 °C during the SEM-image analyses. dExoIII displayed sustained release profile. It was found that dynamic light scattering (DLS) and nanoparticle tracking analysis (NTA) results were in good agreement with each other. Zeta potentials of loaded dexosomes have approximately between −15 to −20 mV; and, their sizes are 150 nm even after ultrasonication. IDcJAWSII dexosomes can be able to be utilized as the “BioNanoMaterial” after DOX loading via ultrasonication technique.

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Section: Discussionmentioning

confidence: 99%

Efficient Doxorubicin Loading to Isolated Dexosomes of Immature JAWSII Cells: Formulated and Characterized as the Bionanomaterial

et al. 2020

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“…Mukherjee and co-workers reported the synthesis of poly ethylene glycol (PEG) assisted colloidal platinum nanoparticles (PtNPs) by borohydride reduction method at room temperature [ 63 ]. PtNPs were stable at room temperature for more than 2 years and also in a serum and phosphate buffer (pH = 7.4) solution for one week.…”

Section: Nanoparticles Useful For Melanoma Treatmentmentioning

confidence: 99%

Recent Advances in Nanotechnology for the Treatment of Melanoma

et al. 2021

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Melanoma is one of the most aggressive forms of skin cancer, with few possibilities for therapeutic approaches, due to its multi-drug resistance and, consequently, low survival rate for patients. Conventional therapies for treatment melanoma include radiotherapy, chemotherapy, targeted therapy, and immunotherapy, which have various side effects. For this reason, in recent years, pharmaceutical and biomedical research has focused on new sito-specific alternative therapeutic strategies. In this regard, nanotechnology offers numerous benefits which could improve the life expectancy of melanoma patients with very low adverse effects. This review aims to examine the latest advances in nanotechnology as an innovative strategy for treating melanoma. In particular, the use of different types of nanoparticles, such as vesicles, polymers, metal-based, carbon nanotubes, dendrimers, solid lipid, microneedles, and their combination with immunotherapies and vaccines will be discussed.

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“…It modifies the proteins and peptides, antibody fragments and oligonucleotides (Savale, 2016). PEGylation of nanoparticles is a widespread technique that upsurges blood passage and retaining time, drops prompt clearance along with nonspecific interfaces using serum proteins (Pelaz et al, 2015;Mukherjee et al, 2020). PEG provide more stability for drug transfer and improved circulation period (Liu et al, 2016).…”

Section: Pegylationmentioning

confidence: 99%

Approaches and Recent Advances in Protein and Peptide Drug Delivery System

Naz¹,

Saeed²,

Irfan³

2020

Pakistan J. Med. Health Sci.

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Peptide and protein drug are commercially available as therapeutics and are prepared by various biotechnology processes.As they lack drug stability during their delivery, so protein structures are modified to maintain pharmaceutical properties of proteins. Various approaches for delivery of protein and peptide drugs are used for proper formulation of drugs. In addition, various advancements in protein and peptide drug delivery have try to overcome the issues during delivery of these therapeutics like increased stability, low toxicity level and increased resistance to proteolytic inactivation, bioavailability, efficiency and improve circulation period. There is a need to develop multifunctional drugdelivery systems and advance technologies that allow production of high quality products at affordable cost. The study was conducted to check various approaches and recent advances in protein/peptide drug delivery system to improve patient compliance when compared with conventionalmethods for drug delivery.

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Improved delivery of doxorubicin using rationally designed PEGylated platinum nanoparticles for the treatment of melanoma

Cited by 76 publications

References 48 publications

Efficient Doxorubicin Loading to Isolated Dexosomes of Immature JAWSII Cells: Formulated and Characterized as the Bionanomaterial

Efficient Doxorubicin Loading to Isolated Dexosomes of Immature JAWSII Cells: Formulated and Characterized as the Bionanomaterial

Recent Advances in Nanotechnology for the Treatment of Melanoma

Approaches and Recent Advances in Protein and Peptide Drug Delivery System

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