Improved delivery of natural alkaloids into lung cancer through woody oil-based emulsive nanosystems

Zhao, Jing; Liu, Shan; Hu, Xueyuan; Zhang, Yunmei; Yan, Sheng-Lei; Zhao, Hua; Zeng, Mei; Li, Yao; Yang, Lan; Zhang, Jingqing

doi:10.1080/10717544.2018.1474970

Cited by 27 publications

(14 citation statements)

References 34 publications

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“…To enhance the bioactivity of evodiamine in lung cancer cells, a previous study used the fructus bruceae oil-based emulsive nanosystems to increase the bioavailability of evodiamine in A549 cells [ 41 ]. Moreover, the antitumor effects of evodiamine were also enhanced with the emulsive nanosystems in A549-tumor-bearing mice [ 42 ].…”

Section: Pharmacological Activitymentioning

confidence: 99%

Antiproliferative Effects of Alkaloid Evodiamine and Its Derivatives

Chang

et al. 2018

IJMS

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Alkaloids, a category of natural products with ring structures and nitrogen atoms, include most U.S. Food and Drug Administration approved plant derived anti-cancer agents. Evodiamine is an alkaloid with attractive multitargeting antiproliferative activity. Its high content in the natural source ensures its adequate supply on the market and guarantees further medicinal study. To the best of our knowledge, there is no systematic review about the antiproliferative effects of evodiamine derivatives. Therefore, in this article the review of the antiproliferative activities of evodiamine will be updated. More importantly, the antiproliferative activities of structurally modified new analogues of evodiamine will be summarized for the first time.

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Section: Pharmacological Activitymentioning

confidence: 99%

Antiproliferative Effects of Alkaloid Evodiamine and Its Derivatives

Chang

et al. 2018

IJMS

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“…The microemulsion was prepared by aqueous titration method and pseudoternary phase diagrams were constructed to identify the optimal microemulsion formulation by comparison of the area of the microemulsion (Zhao et al., 2018 ). As depicted in Figure S1 , the total area of the microemulsion reached the maximum when Cremophor RH40 and PEG400 were used as the surfactant and cosurfactant respectively with the K m at 3:1.…”

Section: Resultsmentioning

confidence: 99%

Ganoderma lucidum-derived polysaccharide enhances coix oil-based microemulsion on stability and lung cancer-targeted therapy

et al. 2018

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The aim of this study is to explore the influence of Ganoderma lucidum-derived polysaccharides (GLP) to coix oil-based microemulsion on pharmaceutical performance and anti-lung cancer treatment. GLP-integrated coix oil-based microemulsion (MEs(PS-GLP)) exhibited a clear spherical shape, small particle size, and good hydrodynamics similar to the coix oil-based microemulsion, but showed a lower zeta potential and a better stability. Fluorescence resonance energy transfer analysis presented that GLP was integrated with microemulsion as a single system. Notably, the average molecular distance between polysaccharide and microemulsion was approximately 1.7 nm. The half-maximal inhibitory concentration of MEs(PS-GLP) against A549 cells was about 119 μg/mL. In vivo imaging studies showed that introduction of GLP promoted the tumor-specific accumulation of microemulsion in comparison with controls. In vivo, antitumor results showed that MEs(PS-GLP) markedly inhibited the tumor growth of A549-bearing xenograft nude mice and obviously improve the serum immune index. Collectively, this study demonstrates the potential mechanism of spatial relation between polysaccharides and microemulsion and validates the significances of GLP on tumoral accumulation and antitumor efficacy.

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“…45 Approximately 40-70% of all clinical drugs are subjected to glucuronidation reactions metabolized by uridine diphosphate-glucuronosyl transferases (UGTs) in humans. 46 UGTs are a superfamily of membrane-bound enzymes that catalyze the formation of https://doi.org/10.2147/IJN.S315705…”

Section: Enzymatic System Related To Metabolism Of Avdsmentioning

confidence: 99%

Antiviral Drug Delivery System for Enhanced Bioactivity, Better Metabolism and Pharmacokinetic Characteristics

Chen¹,

Wang²,

Song³

et al. 2021

IJN

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Antiviral drugs (AvDs) are the primary resource in the global battle against viruses, including the recent fight against corona virus disease 2019 . Most AvDs require multiple medications, and their use frequently leads to drug resistance, since they have poor oral bioavailability and low efficacy due to their low solubility/low permeability. Characterizing the in vivo metabolism and pharmacokinetic characteristics of AvDs may help to solve the problems associated with AvDs and enhance their efficacy. In this review of AvDs, we systematically investigated their structure-based metabolic reactions and related enzymes, their cellular pharmacology, and the effects of metabolism on AvD pharmacodynamics and pharmacokinetics. We further assessed how delivery systems achieve better metabolism and pharmacology of AvDs. This review suggests that suitable nanosystems may help to achieve better pharmacological activity and pharmacokinetic behavior of AvDs by altering drug metabolism through the utilization of advanced nanotechnology and appropriate administration routes. Notably, such AvDs as ribavirin, remdesivir, favipiravir, chloroquine, lopinavir and ritonavir have been confirmed to bind to the severe acute respiratory syndrome-like coronavirus (SARS-CoV-2) receptor and thus may represent anti-COVID-19 treatments. Elucidating the metabolic and pharmacokinetic characteristics of AvDs may help pharmacologists to identify new formulations with high bioavailability and efficacy and help physicians to better treat virus-related diseases, including COVID-19.

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Improved delivery of natural alkaloids into lung cancer through woody oil-based emulsive nanosystems

Cited by 27 publications

References 34 publications

Antiproliferative Effects of Alkaloid Evodiamine and Its Derivatives

Antiproliferative Effects of Alkaloid Evodiamine and Its Derivatives

Ganoderma lucidum-derived polysaccharide enhances coix oil-based microemulsion on stability and lung cancer-targeted therapy

Antiviral Drug Delivery System for Enhanced Bioactivity, Better Metabolism and Pharmacokinetic Characteristics

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