Improved delivery system for celastrol-loaded magnetic Fe3O4/α-Fe2O3 heterogeneous nanorods: HIF-1α-related apoptotic effects on SMMC-7721 cell

Liu, Ruijiang; Lv, Zhixiang; Liu, Xiao; Pan, Shuai; Yin, Ruitong; Yu, Lulu; Li, You; Zhang, Yanling; Zhang, Shaoshuai; Lu, Rongzhu; Li, Yongjin; Li, Shasha

doi:10.1016/j.msec.2021.112103

Cited by 15 publications

(5 citation statements)

References 90 publications

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“…Prussian blue test could certify whether magnetic α-Fe 2 O 3 /Fe 3 O 4 heterostructure nanorods could enter into the HepG2 cells, as shown in figure 6, compared with the control (figure 6(A)), many of the HepG2 cells in the magnetic nanomaterial group (figure 6(B)) had blue particles. The reason was that Fe 3+ reacted with Prussian blue to form a blue precipitate of ferricyanide [27]. The results suggested that magnetic α-Fe 2 O 3 /Fe 3 O 4 heterostructure nanorods could be taken up by HepG2 cells, indicating that magnetic α-Fe 2 O 3 /Fe 3 O 4 heterostructure nanorods could be used as a drug carrier to deliver targeted drugs into HepG2 cells.…”

Section: Resultsmentioning

confidence: 98%

“…According to the morphologies of nanomaterials, they can be divided into many species such as nanoparticles [23], nanosheets [24], nanotubes [25], and nanorods [26], etc Compared with other nanomaterials, nanorods are often used as targeted carriers because they are easier to penetrate cell membranes, etc [27]. Therefore, magnetic α-Fe 2 O 3 /Fe 3 O 4 heterostructure nanorods are chosen as the targeted drug carrier.…”

Section: Introductionmentioning

confidence: 99%

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Fabrication of magnetic α-Fe₂O₃/Fe₃O₄ heterostructure nanorods via the urea hydrolysis-calcination process and their biocompatibility with LO₂ and HepG₂ cells

Zhu,

Ouyang,

Ling

et al. 2023

Nanotechnology

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β-FeOOH nanorods were prepared via the urea hydrolysis process with the average length of 289.1 nm and average diameter of 61.2 nm, while magnetic α-Fe2O3/Fe3O4 heterostructure nanorods were prepared via the urea calcination process with β-FeOOH nanorods as precursor, and the optimum conditions were the calcination temperature of 400 °C, the calcination time of 2 h, the β-FeOOH/urea mass ratio of 1:6. The average length, diameter, and the saturation magnetization of the heterostructure nanorods prepared under the optimum conditions were 328.8 nm, 63.4 nm and 42 emu·g−1, respectively. The Prussian blue test demonstrated that the heterostructure nanorods could be taken up by HepG2 cells, and cytotoxicity tests proved that the heterostructure nanorods had no significant effect on the viabilities of LO2 and HepG2 cells within 72 h in the range of 100–1600 μg·ml−1. Therefore, magnetic α-Fe2O3/Fe3O4 heterostructure nanorods had better biocompatibility with LO2 and HepG2 cells.

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Section: Resultsmentioning

confidence: 98%

Section: Introductionmentioning

confidence: 99%

Fabrication of magnetic α-Fe₂O₃/Fe₃O₄ heterostructure nanorods via the urea hydrolysis-calcination process and their biocompatibility with LO₂ and HepG₂ cells

Zhu,

Ouyang,

Ling

et al. 2023

Nanotechnology

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“…In addition, it requires a short production cycle and only one solvent for the process, and the properties of its product can be easily controlled by changing the solvent volume. Therefore, the combustion method is often use for the preparation of magnetic nanoparticles [12,13].…”

Section: Introductionmentioning

confidence: 99%

Preparation of magnetic cobalt-cuprum-zinc ferrite nanoparticles and their adsorption mechanism of methyl blue

Ouyang¹,

Pan²,

Liu³

et al. 2022

Mater. Res. Express

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Magnetic cobalt-cuprum-zinc ferrites were prepared from anhydrous ethanol using the combustion method, and their structure and properties were characterized using the XRD, SEM, EDS, and VSM techniques, and its formation mechanism was discussed. The magnetic Co0.4Cu0.2Zn0.4Fe2O4 nanoparticles calcined at 400 oC with 25 mL anhydrous ethanol were used for the removal of methyl blue (MB). The results showed that the pseudo-second-order kinetic model best agreed with the adsorption method. In addition, analysis of the adsorption isotherms using the Freundlich, Langmuir, and Temkin models showed that theTemkin model was most consistent with experimental results, which revealed that the adsorption of MB onto the Co0.4Cu0.2Zn0.4Fe2O4 nanoparticles was a multi-molecular layer chemisorption. Further, the influence of pH on the adsorption capacity was evaluated and was highest at pH 11. The cyclability and removal rate of the nanoparticles were explored. The removal rate was approximately 80% after 7 cycles, revealing that the magnetic CoxCuyZn(1-x-y)Fe2O4 nanoparticles are important for wastewater treatment.

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“…Cotemporary techniques for synthesizing magnetic nanomaterials include the coprecipitation process [16], sol-gel process [17], hydrothermal process [18], nitrate solution combustion process [19,20] and so on. Among these, the nitrate solution combustion process is preferred owing to its short production cycle, uniform production particle size, and facile operation [21][22][23][24].…”

Section: Introductionmentioning

confidence: 99%

Adsorption performance of magnetic Mg_0.5Ni_0.5Fe₂O₄ nanoparticles for reactive red 2BF

Ouyang

Liu

Wang

et al. 2022

Mater. Res. Express

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A novel nitrate solution combustion process for formation of magnetic Mg0.5Ni0.5Fe2O4 nanoparticles was introduced, and XRD, VSM, SEM, TEM, and BET techniques were employed to characterize the nanoparticles. For Mg0.5Ni0.5Fe2O4 nanoparticles prepared at 400 °C for 2 h with 20 mL absolute ethanol, the average size and the saturation magnetization were approximately 22 nm and 8.1 A·m2/kg, respectively. Mg0.5Ni0.5Fe2O4 nanomaterials were subjected to reactive red 2BF adsorption, and the adsorption performances were investigated. The results revealed that the experimental data fit the Temkin isotherm model and the pseudo-second-order kinetics model, suggesting that the RR-2BF adsorption process was a monolayer-multilayer-associated chemisorption mechanism. The effects of pH on the adsorption capacity and cycle capacity of the magnetic Mg0.5Ni0.5Fe2O4 nanoparticles for the adsorption of reactive red 2BF were revealed.

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Improved delivery system for celastrol-loaded magnetic Fe3O4/α-Fe2O3 heterogeneous nanorods: HIF-1α-related apoptotic effects on SMMC-7721 cell

Cited by 15 publications

References 90 publications

Fabrication of magnetic α-Fe₂O₃/Fe₃O₄ heterostructure nanorods via the urea hydrolysis-calcination process and their biocompatibility with LO₂ and HepG₂ cells

Fabrication of magnetic α-Fe₂O₃/Fe₃O₄ heterostructure nanorods via the urea hydrolysis-calcination process and their biocompatibility with LO₂ and HepG₂ cells

Preparation of magnetic cobalt-cuprum-zinc ferrite nanoparticles and their adsorption mechanism of methyl blue

Adsorption performance of magnetic Mg_0.5Ni_0.5Fe₂O₄ nanoparticles for reactive red 2BF

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Improved delivery system for celastrol-loaded magnetic Fe3O4/α-Fe2O3 heterogeneous nanorods: HIF-1α-related apoptotic effects on SMMC-7721 cell

Cited by 15 publications

References 90 publications

Fabrication of magnetic α-Fe2O3/Fe3O4 heterostructure nanorods via the urea hydrolysis-calcination process and their biocompatibility with LO2 and HepG2 cells

Fabrication of magnetic α-Fe2O3/Fe3O4 heterostructure nanorods via the urea hydrolysis-calcination process and their biocompatibility with LO2 and HepG2 cells

Preparation of magnetic cobalt-cuprum-zinc ferrite nanoparticles and their adsorption mechanism of methyl blue

Adsorption performance of magnetic Mg0.5Ni0.5Fe2O4 nanoparticles for reactive red 2BF

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Product

Resources

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Fabrication of magnetic α-Fe₂O₃/Fe₃O₄ heterostructure nanorods via the urea hydrolysis-calcination process and their biocompatibility with LO₂ and HepG₂ cells

Fabrication of magnetic α-Fe₂O₃/Fe₃O₄ heterostructure nanorods via the urea hydrolysis-calcination process and their biocompatibility with LO₂ and HepG₂ cells

Adsorption performance of magnetic Mg_0.5Ni_0.5Fe₂O₄ nanoparticles for reactive red 2BF