Improved Detection of Adenocarcinoma of Serous Fluids with p53 Immunocytochemistry

Saleh, Husain; Bober, Paula; Tabaczka, Pamela

doi:10.1159/000332163

Cited by 5 publications

(3 citation statements)

References 16 publications

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“…115 In a study of cell blocks from pleural and peritoneal effusions, p53 positivity was found in 11 of 18 cases of AdCa and 3 of 4 suspicious specimens compared to 1 in 14 benign cases. 116 Immunocytochemical detection of p53 and other markers on ThinPrep was compared to cell block from the same effusion specimens.…”

Section: Evaluation Of Apoptosis In Cytologic Specimensmentioning

confidence: 98%

Evaluation of apoptosis in cytologic specimens

Shtilbans¹,

Burstein

2010

Diagnostic Cytopathology

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A hallmark of neoplasia is dysregulated apoptosis, programmed cell death. Apoptosis is crucial for normal tissue homeostasis. Dysregulation of apoptotic pathways leads to reduced cytocidal responses to chemotherapeutic drugs or radiation and is a frequent contributor to therapeutic resistance in cancer. The literature pertaining to detection of apoptotic pathway constituents in cytologic specimens is reviewed herein. Virtually all methods for detecting apoptosis, including classic cytomorphologic evaluation, TUNEL assay, immunocytochemistry, and gene sequence analysis, may be applied to cytologic samples as well as tissue. Components of both intrinsic and extrinsic apoptotic pathways have been studied, including many reports examining p53 and bcl-2, as well as studies of caspase inhibitory proteins XIAP and survivin, death receptors and ligands such as Fas, Fas-ligand, and TRAIL. p53 undergoes oncogenic alteration more than any other protein; its immunocytochemical detection almost always connotes loss of its physiologic role as an inducer of apoptosis in response to a damaged genome. Several reports establish cytologic sampling as being as useful as tissue sampling. In one respect cytologic sampling is superior to tissue sampling in particular, by allowing clinicians to repeat sampling of the same tumor before and after administration of therapy; a number of reports use this approach to attempt to predict tumor response by assaying the effect of chemotherapy on the induction of apoptosis.

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Section: Evaluation Of Apoptosis In Cytologic Specimensmentioning

confidence: 98%

Evaluation of apoptosis in cytologic specimens

Shtilbans¹,

Burstein

2010

Diagnostic Cytopathology

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show abstract

“…Recently it has been suggested that positive staining with proliferation markers such as p53 62 , 63 and Ki67 64 can be used to support a diagnosis of malignancy. The value of proliferation markers is yet to be fully evaluated, but does show some promise.…”

Section: The Immunocytochemical Approachmentioning

confidence: 99%

Invited review The cytology of malignant mesothelioma

Whitaker

2000

Cytopathology

127

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“…Two of eight suspicious cases stained positively, both were determined to have metastatic AdCa. Carcinoembryonic antigen (CEA) was also studied; the authors suggest p53 and CEA positivity in suspicious cases may help detect malignancy 115…”

Section: Apoptosis In Cytological Specimens From Specific Tissuesmentioning

confidence: 99%

Chemotherapy with rituximab followed by high‐dose therapy and autologous stem cell transplantation in patients with mantle cell lymphoma

Thiéblemont

Antal

Lacotte‐Thierry

et al. 2005

Cancer

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A hallmark of neoplasia is dysregulated apoptosis, programmed cell death. Apoptosis is crucial for normal tissue homeostasis. Dysregulation of apoptotic pathways leads to reduced cytocidal responses to chemotherapeutic drugs or radiation and is a frequent contributor to therapeutic resistance in cancer. The literature pertaining to detection of apoptotic pathway constituents in cytologic specimens is reviewed herein. Virtually all methods for detecting apoptosis, including classic cytomorphologic evaluation, TUNEL assay, immunocytochemistry, and gene sequence analysis, may be applied to cytologic samples as well as tissue. Components of both intrinsic and extrinsic apoptotic pathways have been studied, including many reports examining p53 and bcl‐2, as well as studies of caspase inhibitory proteins XIAP and survivin, death receptors and ligands such as Fas, Fas‐ligand, and TRAIL. p53 undergoes oncogenic alteration more than any other protein; its immunocytochemical detection almost always connotes loss of its physiologic role as an inducer of apoptosis in response to a damaged genome. Several reports establish cytologic sampling as being as useful as tissue sampling. In one respect cytologic sampling is superior to tissue sampling in particular, by allowing clinicians to repeat sampling of the same tumor before and after administration of therapy; a number of reports use this approach to attempt to predict tumor response by assaying the effect of chemotherapy on the induction of apoptosis. Diagn. Cytopathol. 2010;38:685–697. © 2010 Wiley‐Liss, Inc.

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Improved Detection of Adenocarcinoma of Serous Fluids with p53 Immunocytochemistry

Cited by 5 publications

References 16 publications

Evaluation of apoptosis in cytologic specimens

Evaluation of apoptosis in cytologic specimens

Invited review The cytology of malignant mesothelioma

Chemotherapy with rituximab followed by high‐dose therapy and autologous stem cell transplantation in patients with mantle cell lymphoma

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