Improved Dissolution Rate of Piroxicam by Fusion Solid Dispersion Technique

Abstract

Article Information Improving oral bioavailability of drugs those given as solid dosage forms remains a challenge for the formulation scientists due to solubility problems. The dissolution rate could be the rate-limiting process in the absorption of a drug from a solid dosage form of relatively insoluble drugs. Therefore increase in dissolution of poorly soluble drugs by solid dispersion technique presents a challenge to the formulation scientists. In the present work solid dispersed drug was prepared by Fusion technique as a novel system for enhancing the delivery of piroxicam, a non-steroidal anti-inflammatory drug. This solid dispersed drug was prepared from polyvinyl pyrrolidone (PVP) (pharmaceutical grade), a biodegradable polymer, to obtain a solution with drug: polymer ratio of 1:5. The release rate of the piroxicam solid dispersed drug was studied in simulated gastric fluid. Fourier transform infrared (FTIR) and scanning electron microscopy (SEM) are used to evaluate the chemical and physical nature. The results showed that the release rates were twice increased in comparison with the pure drug. However, the blend of drug and polymer could be varied to optimize the release rates depending upon the need and formulation.

Formulation and Characterization of Piroxicam as Self-Nano Emulsifying Drug Delivery System

“…In this study, the peak at 1637.27 cm -1 was found in IR spectrum of PIR, suggesting that the needle form of PIR was used in the present study (37) . The PIR spectra also exhibited other characteristic peaks like, C=C stretching of aromatic ring at 1434.78 cm -1 , C-N stretching at 1351.86 cm -1 , C-O stretching at 1288.22 cm -1 , S(=O)2 stretching at 1149.37cm -1 , -SO2-N stretching at 1033.66 cm -1 , aromatic CH bending at 825.38 cm -1 , ortho-disubstituted phenyl at 771.39 cm -1 and C-S stretching at 669.18 cm -1 , which indicate purity of drug (38)(39)(40) . From the FTIR results, it was found there was no changes in the peaks of PIR spectrum to that of the spectra of the selected formula F4, the results indicate that no chemical interactions have been happened between the PIR and excipients that utilized in the preparation.…”

Preparation, Characterization and <i>In Vitro</i> Drug Release Studies of 6-mercaptopurine Thin Film

“…At predetermined time intervals (0, 15, 30 min, 1 h, 2 h, 3 h, 4 h, 8 h, 12 h, 16 h, 24 h and 48 h, an aliquot of 4 ml of the release media was withdrawn and the concentration of the drug in release media was estimated by UV spectroscopy (Evolution 300; Thermo Fisher Scientific, USA) at 325nm. The dissolution medium was replaced with fresh buffer (4ml) to maintain constant total volume (Manohara et al, 2014).…”