2003
DOI: 10.1016/j.jtcvs.2003.07.029
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Improved early outcome for end-stage dilated cardiomyopathy in children

Abstract: Recent refinements in the management of end-stage dilated cardiomyopathy in children have significantly reduced early mortality. Identification of markers of early myocardial recovery and development of mechanical devices for longer term and more physiologic support are essential to achieve further improvements in outcome.

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Cited by 42 publications
(31 citation statements)
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“…1 Survival can be improved by more aggressive use of transplantation and mechanical circulatory support. 2,3 Although the decision to perform a heart transplantation (HTx) for a child on inotropes or mechanical support is straightforward, risk stratification of ambulatory pediatric outpatients with dilated cardiomyopathy (DCM) remains challenging. However, it is also clear that children who are stable at home with chronic heart failure remain at risk of death with a survival benefit of transplantation out to 4 years after transplantation.…”
mentioning
confidence: 99%
“…1 Survival can be improved by more aggressive use of transplantation and mechanical circulatory support. 2,3 Although the decision to perform a heart transplantation (HTx) for a child on inotropes or mechanical support is straightforward, risk stratification of ambulatory pediatric outpatients with dilated cardiomyopathy (DCM) remains challenging. However, it is also clear that children who are stable at home with chronic heart failure remain at risk of death with a survival benefit of transplantation out to 4 years after transplantation.…”
mentioning
confidence: 99%
“…In some patients with cardiomyopathy, after 2-3 week period, adequate ventricular improvement of ECMO weaning had been detected. These patients are put into transplant list and a very close follow-up is done (McMahon et al, 2003). Although there is an increase in the number of pediatric ECMO applications, it is disappointing that the survival rate still remains at 40 % for postcardiotomy patients who have undergone mechanical support (ECLS Registry, 2005).…”
Section: When To End the Mechanical Support?mentioning
confidence: 99%
“…9 -11 Some centers report improved pretransplantation survival in more recent eras as the result of improved medical therapy, innovative strategies to improve the efficiency of donor allocation (eg, ABO incompatible transplantation in infants), and increased use of mechanical support devices in children. [12][13][14][15] Because sudden death in children awaiting heart transplantation is rare, the majority of deaths in this population are due to progressive heart and multi-organ failure and are therefore, at least in theory, amenable to salvage therapy with mechanical circulatory support (MCS). 10 The experience with adults supported long-term by MCS is sobering, with a 66% mortality rate at 1 year.…”
Section: Article P 2313mentioning
confidence: 99%