Improved effect on 2 cases of disseminated superficial actinic porokeratosis with daylight photodynamic therapy

Effects of Blue Light on the Skin and Its Therapeutic Uses: Photodynamic Therapy and Beyond

“…These 2 patients experienced approximately 70% lesion reduction with good cosmetic outcome and no relapse at the 1-year follow-up. 61 There is also a report of several facial flat warts successfully treated with 2 sessions of DL-PDT separated by 1 month. The patient experienced complete resolution of all warts without scarring.…”

Improvements in two subtypes of porokeratosis by superficial X‐ray radiotherapy

“…used to treat the skin disorder with conflicting results. 2,4 Although photodynamic therapy has shown efficacy in recent cases, 5 its application is limited because of its high cost and the painful experience of patients. Thus, we attempted a novel treatment regimen for both patients.…”

Porokeratoses—A Comprehensive Review on the Genetics and Metabolomics, Imaging Methods and Management of Common Clinical Variants

“…Slightly better results were achieved with the use of methyl aminolevulinate (MAL) in one DSAP patient, possibly due to higher lipophilicity and better penetration to the cells [122,123]. In a larger series of 13 DSAP patients treated with MAL, 19% of them achieved a >75% reduction in the lesions [124]. In another smaller case series treated using MAL-PDT (mean 5.5 sessions, every 15 days), only a slight reduction in roughness was noted [125].…”

“…MAL-PDT was described to be ultimately unsuccessful in DSAP (33.3% effectiveness) and characterised by an unfavourable safety profile (pigmentation disorders, inflammation, erythema and discomfort) [121]. Salas et al and Guillen et al reported no recurrence after 10 months and 1 year, respectively [123,124]. PDT utilising hypericin (St. John's wort-derived herbal photosensitiser) does seem promising.…”