Improved Efficiency of Budesonide Nebulization Using Surface-Active Agents

Abstract

Our aim was to improve the efficiency of nebulised budesonide using surface-active agents. Cationic, anionic, and nonionic detergents were added to commercial budesonide suspension, and the particle size distribution during nebulization was measured using both cascade impaction and laser diffraction. Our results showed that the emitted dose was increased after addition of cationic (p < 0.001) and nonionic detergents (p < 0.01) compared with the commercial formulation alone. The respirable fraction was increased for all detergent formulations (p < 0.001) compared with the commercial formulation. We concluded that cationic and nonionic detergent increased the total output of budesonide from the Sidestream. All detergent formulations increased the respirable fraction of nebulized budesonide.

Preparation and Characterization of a Novel Multiparticulate Dosage Form Carrying Budesonide-Loaded Chitosan Nanoparticles to Enhance the Efficiency of Pellets in the Colon

“…All prepared formulations showed positive zeta-potential ranges from +26.6 ± 1.1 to +31.0 ± 1.2 mV. Since BU is a slightly anionic molecule [ 72 ], positive zeta potentials are due to the positively charged amino groups of chitosan molecules present at the surface of particles. It can be postulated that nanoparticles with zeta potential below −25 mV and above +25 mV can be considered stable at physiological pH [ 73 ]; therefore, all nanoparticles produced in the current study can be expected to be stable under physiological conditions.…”