Improved exercise performance following single daily dose of atenolol in stable angina

Balu, V.; Masud, Arif; Dean, David C.; Naughton, John

doi:10.1016/0167-5273(83)90057-8

International Journal of Cardiology

1983

DOI: 10.1016/0167-5273(83)90057-8

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Improved exercise performance following single daily dose of atenolol in stable angina

V. Balu¹,

Arif Masud²,

David C. Dean³

et al.

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1985

1991

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Cited by 2 publications

References 6 publications

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Beta-Blockade and Response to Exercise: Influence of Training

Wilmore¹,

Joyner²,

Freund³

et al. 1985

The Physician and Sportsmedicine

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In brief: Beta-blockers and exercise training are recommended for treating cardiovascular disease and hypertension, and researchers have tried to determine the interaction of these two treatment modalities. Data from four studies conducted on 93 subjects over the past five years show that beta-blockade exerts a differential effect on the exercise capacity of subjects of different levels of health and fitness: It increases the capacity of angina patients; decreases the capacity of highly trained, fit individuals; and has little or no effect on the capacity of healthy, untrained individuals.

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Beta-Blockade and Response to Exercise: Influence of Training

Wilmore¹,

Joyner²,

Freund³

et al. 1985

The Physician and Sportsmedicine

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Bopindolol in chronic stable angina pectoris: duration and extent of antianginal action.

Carboni,

Scardovi,

D'Ermo

et al. 1991

Brit J Clinical Pharma

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The effects of bopindolol, a new beta‐adrenoceptor blocker, on the exercise tolerance of 12 in‐patients, mean age 57 (5 years), with stable angina pectoris and documented coronary artery disease were evaluated. All patients received on 4 different days a single oral dose of bopindolol 0.5 mg, bopindolol 1.0 mg, bopindolol 2.0 mg and placebo according to a double‐blind latin square design. Treadmill symptoms‐ limited exercise tests were performed using a Bruce protocol, 3, 12 and 24 h after dosing. Bipindolol improved (P less than 0.05) exercise tolerance in comparison with placebo (by a maximum of 33%, 52% and 26% after the 2.0 mg dose) with no adverse effect on ischaemia. The primary action of bopindolol appeared to be to reduce myocardial oxygen consumption (mainly by its negative chronotropic effect) for up to the 24th hour after oral administration. Eight (66%) patients were angina free at the 3rd, 12th and 24th h exercise test. The effects of bopindolol were not dose‐related. A short period of inactivity due to hospitalization may have influenced the exercise performance and led us to underestimate the presence of a dose‐response. The results of this report suggest that bopindolol has a long lasting effect in the treatment of patients with chronic stable angina pectoris.

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Improved exercise performance following single daily dose of atenolol in stable angina

Cited by 2 publications

References 6 publications

Beta-Blockade and Response to Exercise: Influence of Training

Beta-Blockade and Response to Exercise: Influence of Training

Bopindolol in chronic stable angina pectoris: duration and extent of antianginal action.

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