Improved frequency/voltage converters for fast quartz crystal microbalance applications

Torres, Róbinson; García, José Manuel Miralles; Arnau, Antonio; Perrot, Hubert; Kim, L. To Thi; Gabrielli, C.

doi:10.1063/1.2908430

Cited by 14 publications

(12 citation statements)

References 17 publications

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“…Key advances in the field of acoustics and biophysics will continue to drive forward the sensitivity and specificity limits of piezoelectric assays. These include ultra‐thin, high frequency ‘inverted mesa’ sensors formed by deep‐reactive ion etching (Abe and Kato, 2007), novel sensors with both electrodes on one face of the quartz (Abe and Kato, 2007) or no electrodes (Ogi et al , 2006; Ogi et al , 2007; Larsson et al , 2009; Ogi et al ., 2009a; Ogi et al ., 2009b), novel drive and electronic interface circuits (Arnau et al , 2008; Torres et al , 2008), multiplexed sensor arrays (Hsiao et al , 2009), and systems capable of operating at multiple frequencies and oscillation amplitudes (Cooper et al , 2001; Edvardsson et al , 2005; Kankare et al , 2006). More recently completely new micromechanical devices based on the principles of resonant acoustic biosensing have appeared involving torsional piezoelectric (Bucking et al , 2007) and suspended piezoelectric resonators (Burg et al , 2007).…”

Section: Discussionmentioning

confidence: 99%

A survey of the 2006–2009 quartz crystal microbalance biosensor literature

Becker

Cooper

2011

J of Molecular Recognition

163

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Since the publication of the original review of piezoelectric acoustic sensors in this series there has been a consistent, gradual expansion in the number of published papers using 'quartz crystal microbalances' (QCM). Between 2001 and 2009, the number of QCM publications per annum has increased from 49 to 273, with a two-fold increase in papers per annum between 2004 and 2008. Within the field, comparing the time covered by the current to the previous review, there are trends towards increasing use of QCM in the study of protein adsorption to surfaces (93% increase), homeostasis (67% increase), protein-protein interactions (40% increase) and carbohydrates (43% increase). New commercial systems have been released that are driving the uptake of the technology for characterization of binding specificities, affinities, kinetics and conformational changes associated with a molecular recognition event. This paper highlights theoretical and practical aspects of the principles that underpin acoustic analysis, then reviews exemplary papers in key application areas involving small molecular weight ligands, carbohydrates, proteins, nucleic acids, viruses, bacteria, cells and membrane interfaces.

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Section: Discussionmentioning

confidence: 99%

A survey of the 2006–2009 quartz crystal microbalance biosensor literature

Becker

Cooper

2011

J of Molecular Recognition

163

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“…Thus, the analyzer selection should take such points into consideration [ 63 , 74 ]. Other electronic characterization techniques based on lock-in oscillator concepts were also introduced in literature to overcome the problem for fast QCM applications [ 75 ].…”

Section: Qcm Electronic Interfacing Systems For Sensing Applicatiomentioning

confidence: 99%

Quartz Crystal Microbalance Electronic Interfacing Systems: A Review

Alassi

Benammar

Brett

2017

Sensors

159

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Quartz Crystal Microbalance (QCM) sensors are actively being implemented in various fields due to their compatibility with different operating conditions in gaseous/liquid mediums for a wide range of measurements. This trend has been matched by the parallel advancement in tailored electronic interfacing systems for QCM sensors. That is, selecting the appropriate electronic circuit is vital for accurate sensor measurements. Many techniques were developed over time to cover the expanding measurement requirements (e.g., accommodating highly-damping environments). This paper presents a comprehensive review of the various existing QCM electronic interfacing systems. Namely, impedance-based analysis, oscillators (conventional and lock-in based techniques), exponential decay methods and the emerging phase-mass based characterization. The aforementioned methods are discussed in detail and qualitatively compared in terms of their performance for various applications. In addition, some theoretical improvements and recommendations are introduced for adequate systems implementation. Finally, specific design considerations of high-temperature microbalance systems (e.g., GaPO 4 crystals (GCM) and Langasite crystals (LCM)) are introduced, while assessing their overall system performance, stability and quality compared to conventional low-temperature applications.

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“…A system proposed for solving this problem in ac -electrogravimetry applications has been introduced elsewhere [55, 107-109] whose block diagram is shown in Figure 23.…”

Section: Systems For Sensor Parameter Characterizationmentioning

confidence: 99%

A Review of Interface Electronic Systems for AT-cut Quartz Crystal Microbalance Applications in Liquids

Arnau

2008

Sensors

163

133

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From the first applications of AT-cut quartz crystals as sensors in solutions more than 20 years ago, the so-called quartz crystal microbalance (QCM) sensor is becoming into a good alternative analytical method in a great deal of applications such as biosensors, analysis of biomolecular interactions, study of bacterial adhesion at specific interfaces, pathogen and microorganism detection, study of polymer film-biomolecule or cell-substrate interactions, immunosensors and an extensive use in fluids and polymer characterization and electrochemical applications among others. The appropriate evaluation of this analytical method requires recognizing the different steps involved and to be conscious of their importance and limitations. The first step involved in a QCM system is the accurate and appropriate characterization of the sensor in relation to the specific application. The use of the piezoelectric sensor in contact with solutions strongly affects its behavior and appropriate electronic interfaces must be used for an adequate sensor characterization. Systems based on different principles and techniques have been implemented during the last 25 years. The interface selection for the specific application is important and its limitations must be known to be conscious of its suitability, and for avoiding the possible error propagation in the interpretation of results. This article presents a comprehensive overview of the different techniques used for AT-cut quartz crystal microbalance in in-solution applications, which are based on the following principles: network or impedance analyzers, decay methods, oscillators and lock-in techniques. The electronic interfaces based on oscillators and phase-locked techniques are treated in detail, with the description of different configurations, since these techniques are the most used in applications for detection of analytes in solutions, and in those where a fast sensor response is necessary.

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Improved frequency/voltage converters for fast quartz crystal microbalance applications

Cited by 14 publications

References 17 publications

A survey of the 2006–2009 quartz crystal microbalance biosensor literature

A survey of the 2006–2009 quartz crystal microbalance biosensor literature

Quartz Crystal Microbalance Electronic Interfacing Systems: A Review

A Review of Interface Electronic Systems for AT-cut Quartz Crystal Microbalance Applications in Liquids

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