Improved functional recovery of rat transected spinal cord by peptide-grafted PNIPAM based hydrogel

An injectable thermosensitive hydrogel with a self-assembled peptide coupled with an antimicrobial peptide for enhanced wound healing

“…In a recent study, an IKVAV peptide-grafted PNIPAM hydrogel was fabricated to treat a traumatic disease that inhibits the formation of glial scar tissue and repairs damaged tissue. 73 A crosslinked PNIPAM grafted sodium alginate injectable dressing was prepared for wound healing which was able to form a thermosensitive gel in situ for the release of curcumin to achieve antioxidant and anti-inflammatory properties. 74 A hyaluronic acid (HA)-based composite hydrogel, with an antimicrobial peptide [AMP, KK(SLKL)3KK] as a cross-linking agent was explored as an antibiotic-free hydrogel-based biomaterial that exhibits the characteristics of acid triggering AMP release in the pathological environment of bacterial infected wounds (pH: 5.5–5.6).…”

Mimicking the neural stem cell niche: An engineer’s view of cell: material interactions

“…Biodegradable and biocompatible polymer to support neural stem cell transplantation Shi et al (2009); Bible et al (2009) Polycaprolactone (PCL) FDA-approved synthetic polymer with slow biodegradability, biocompatibility, capability to be chemically functionalized, tailorable flexibility and toughness Amores de Sousa et al (2020) Polyacrylamide (PAAM) Non-toxic, non-resorbable, and hydrophilic polymer with tunable stiffness and ease of handling Pandamooz et al (2020) poly(N-isopropylacrylamide) (pNIPAAm) Thermoresponsive, biocompatible, with good mechanical properties and lower critical solution temperature (LCST) close to physiological temperature Malekzadeh and Zhang Newby (2020); Chai et al (2022) poly(2-hydroxyethyl methacrylate) (pHEMA)…”

Peptide-Based Hydrogels: New Materials for Biosensing and Biomedical Applications

“…Additionally, this RAD/SA1 peptide inhibited the p-ERK expression through Ca 2+ -dependent p-ERK signaling pathways, showing that this peptide hydrogel with the short motif of Sa12b is a suitable scaffold for nucleus pulposus tissue engineering. Chai et al used a peptide hydrogel scaffold to study its effect on the improvement of angiogenesis, inhibition of the differentiation and adhesion of keratinocytes, as well as reduction of the formation of glial scar tissue [ 139 ]. This scaffold showed the promotion of angiogenic factors expression and decreased the secretion of pro-inflammatory factors to a certain extent, as well as showed an inhibition of glial scar tissue formation and could repair damaged tissue, suitable for tissue engineering of the central nervous system (CNS).…”