Improved Glucose Homeostasis in Obese Mice Treated With Resveratrol Is Associated With Alterations in the Gut Microbiome

Abstract

Oral administration of resveratrol is able to improve glucose homeostasis in obese individuals. Herein we show that resveratrol ingestion produces taxonomic and predicted functional changes in the gut microbiome of obese mice. In particular, changes in the gut microbiome were characterized by a decreased relative abundance of Turicibacteraceae, Moryella, Lachnospiraceae, and Akkermansia and an increased relative abundance of Bacteroides and Parabacteroides Moreover, fecal transplantation from healthy resveratrol-fed donor mice is sufficient to improve glucose homeostasis in obese mice, suggesting that the resveratrol-mediated changes in the gut microbiome may play an important role in the mechanism of action of resveratrol.

Hydroxytyrosol in the Prevention of the Metabolic Syndrome and Related Disorders

“…In this sense, modulation of gut microbiota could be the most remarkable local effect exerted by HT. Recently, another component of the Mediterranean diet, resveratrol, has been shown to modulate positively gut microbiota enhancing glucose tolerance in a mice model of obesity [142] and also through a duodenal Sirt-1 pathway into the hypothalamus [143] enhancing hypothalamic insulin-resistance. Sirt-1 is an energy sensitizer upregulating antioxidative and anti-inflammatory gene expression and improving mitochondrial biogenesis through PGC-1α.…”

Characteristic of polysaccharides from Flammulina velutipes in vitro digestion under salivary, simulated gastric and small intestinal conditions and fermentation by human gut microbiota

“…B). As reported, a lower risk of obesity positively correlated with a larger Bacteroidetes to Firmicutes ratio (Sung et al ., ). These two bacteria were mainly related to energy intake and they have different properties on energy conversion and metabolism (Million et al ., ).…”

Identification of therapeutic effect of glucagon‐like peptide 1 in the treatment of STZ‐induced diabetes mellitus in rats by restoring the balance of intestinal flora

“…As a potent incretin, GLP-1 has been clinically used in the medical management of obese or overweight adults with T2DM. 9,10 Several metabolic pathways, such as amino acid metabolism pathways, energy metabolism pathways, and carbohydrate metabolism pathways, are deregulated in obese mice, whereas the treatment by resveratrol can significantly alleviate these disorders. [5][6][7][8] It has been shown that intestinal flora plays an important role in the control of glucose hemeostasis, while resveratrol was found to be able to maintain the glucose hemeostasis by regulating the balance of intestinal flora.…”

“…4 The ability of GLP-1 analogues to induce weight loss has been repeatedly demonstrated in several clinical trials studying the weight loss efficacy of a GLP-1 analogue (liraglutide) in nondiabetic obese and overweight individuals. 9 Furthermore, shotgun metagenomics has shown that the glucose-lowering effects of orally administered resveratrol were exerted by significant modification of gut microbial composition and relevant functional pathways. 9,10 Several metabolic pathways, such as amino acid metabolism pathways, energy metabolism pathways, and carbohydrate metabolism pathways, are deregulated in obese mice, whereas the treatment by resveratrol can significantly alleviate these disorders.…”