Improved growth of preterm infants receiving mother’s own raw milk compared with pasteurized donor milk

Montjaux-Régis, N.; Cristini, C.; Arnaud, Catherine; Glorieux, Isabelle; Vanpée, Mireille; Casper, Charlotte

doi:10.1111/j.1651-2227.2011.02389.x

Cited by 104 publications

(115 citation statements)

References 31 publications

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“…Interestingly, we observed significantly lower rates of severe complications, sepsis, persistent arterial duct, and BPD in neonates receiving early raw MOM. Similar observations have emerged from other recent studies [17,18,22,23,24]. However, a cause-effect relationship cannot be deduced from this observational study.…”

Section: Discussionsupporting

confidence: 61%

“…While pasteurisation prevents CMV transmission, it may alter bioactive and nutritional components [14,15]. Moreover, this process might delay the use of MOM and increase the consumption of donor milk or formula [16,17]. Thus, despite the national recommendations, practices regarding the use of raw MOM vary in French NICUs [17,18].…”

Section: Introductionmentioning

confidence: 99%

“…Moreover, this process might delay the use of MOM and increase the consumption of donor milk or formula [16,17]. Thus, despite the national recommendations, practices regarding the use of raw MOM vary in French NICUs [17,18]. The actual use of raw MOM in hospitalised neonates and its impact on breastfeeding remains unclear.…”

Section: Introductionmentioning

confidence: 99%

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Early Use of Mother's Own Raw Milk, Maternal Satisfaction, and Breastfeeding Continuation in Hospitalised Neonates: A Prospective Cohort Study

et al. 2017

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Background: Despite the critical importance of breast milk for preterm and sick neonates, there is no consensus regarding the use of raw mother's own milk (MOM) in neonatal units. Objectives: This study aimed to describe the use of raw MOM in hospitalised neonates before day 7 (early use), and to investigate: (i) related factors, (ii) maternal satisfaction, and (iii) the association with breastfeeding continuation. Methods: This prospective cohort included 516 neonates intended to be breastfed in 2 French neonatal units. Neonates receiving raw MOM before day 7 were compared to those who did not. The association between early use of MOM and breastfeeding continuation at hospital discharge, and up to 6 months later, was measured by logistic regression. Results: More than one-third (36.2%) of breastfed neonates did not receive any MOM during their first week, mainly due to organisational constraints and staff reluctance. Maternal satisfaction related to early raw MOM use was high (96%), and was coupled with a more frequent maternal feeling of being supported in breastfeeding (p = 0.003). There was a significant association between early use of MOM and breastfeeding continuation at discharge (OR 2.92, 95% CI 1.94-4.40, p < 0.0001), which persisted 6 months later (OR 2.70, 95% CI 1.21-6.03, p = 0.023). This association appeared independent in multivariable analyses (at discharge: aOR 2.03, 95% CI 1.27-3.25, p = 0.003; 6 months later: aOR 2.46, 95% CI 1.02-5.92, p = 0.045). Conclusion: While the early use of raw MOM in hospitalised neonates can be limited by multiple factors, it appears supportive for mothers, and might represent a simple opportunity to improve breastfeeding in neonatal units.

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Section: Discussionsupporting

confidence: 61%

Section: Introductionmentioning

confidence: 99%

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Early Use of Mother's Own Raw Milk, Maternal Satisfaction, and Breastfeeding Continuation in Hospitalised Neonates: A Prospective Cohort Study

et al. 2017

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“…In this context, the methods of increasing breastmilk production of mothers, nursing and breastfeeding should be investigated for preterm babies in neonatal units. The politics and applications of hospitals in relation with milk production, milking and keeping milk should be examined (25).…”

Section: Discussionmentioning

confidence: 99%

Mothers’ views of milk banking: sample of İzmir

2015

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Aim: The studies on human milk banking in Turkey, has being carried out at a hospital in Izmir province. There are different point of views about milk banking. The aim of the study is to determine the knowledge and the views of the mothers towards milk banking. Material and Methods:This study is a cross-sectional survey. The study was carried out with 404 mothers who gave birth in a two maternity hospitals and one university hospital in İzmir using the face-to-face interview technique between March 2014 and June 2014. The study data were collected using a 30-item socio-demographic questionnaire.Results: The mothers' mean age was 28.4 years (16-46 years). Of the mothers, 45.5% were primary school graduates, 80.2% were members of a nuclear family, 75.7% had less than three children, 63.4% gave birth by caesarean section and only 79.5 percent were able to breastfeed before being discharged. Of the mothers, 41.6% were aware of milk banking, 71.3% were willing to receive milk bank services and 68.8% were willing to donate breastmilk. 62.2% of those who did not want to make donation stated risk of contagion as a reason, 8.2% of the participants had worked as wet-nurse before. Conclusions:Most mothers revealed positive approaches and opinions about establishment of milk banking and milk donation. However, there were some concerns due to the risk of infectious diseases and religious beliefs. Efforts should be made to raise awareness and mothers should be informed about the importance of breast milk and breastfeeding so that milk banks can be regarded as an additional choice. (Turk Pediatri Ars 2015; 50: 83-9)

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“…Early introduction of enteral feeding is beneficial for intestinal maturation and protection against NEC, but the quality of the diet may critically affect these positive effects. For example, the feeding of mother's milk matures the preterm gut and reduces the risk of NEC relative to bovine milk-based infant formula (IF) and possibly also banked donor milk (22,29,34,39,40). Donor milk (DM) is normally obtained at a relatively late stage of lactation, and therefore may not be appropriate as the first diet, when infants are supposed to receive mother's colostrum.…”

mentioning

confidence: 99%

Raw bovine milk improves gut responses to feeding relative to infant formula in preterm piglets

Jensen

Chatterton

et al. 2014

American Journal of Physiology-Gastrointestinal and Liver Physi

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Kvistgaard AS, Sangild PT. Raw bovine milk improves gut responses to feeding relative to infant formula in preterm piglets. Am J Physiol Gastrointest Liver Physiol 306: G81-G90, 2014. First published October 24, 2013 doi:10.1152 doi:10. /ajpgi.00255.2013 neonates, the quality of the first milk is crucial for intestinal maturation and resistance to necrotizing enterocolitis (NEC). Among other factors, milk quality is determined by the stage of lactation and processing. We hypothesized that unprocessed mature bovine milk (BM; raw bovine milk) would have less bioactivity than corresponding bovine colostrum (BC) in a preterm pig model, but have improved bioactivity relative to its homogenized, pasteurized, spray-dried equivalent, whole milk powder (WMP), or a bovine milk proteinbased infant formula (IF). For 5 days, newborn preterm pigs received parenteral and enteral nutrition consisting of IF (n ϭ 13), BM (n ϭ 13), or BC (n ϭ 14). In a second study, WMP (n ϭ 15) was compared with IF (n ϭ 10) and BM (n ϭ 9). Compared with pigs fed IF, pigs that were fed BM had significantly improved intestinal structure (mucosal weight, villus height) and function (increased nutrient absorption and enzyme activities, decreased gut permeability, nutrient fermentation, and NEC severity). BC further improved these effects relative to BM (lactase activity, lactose absorption, plasma citrulline, and tissue interleukin-8). WMP induced similar effects as BM, except for lactase activity and lactose absorption. In conclusion, the maturational and protective effects on the immature intestine decreased in the order BCϾBMϾWMP, but all three intact bovine milk diets were markedly better than IF. The stage of lactation (colostrum vs. mature milk) and milk processing (e.g., homogenization, fractionation, pasteurization, spray-drying) are important factors in determining milk quality during the early postnatal period of preterm neonates. colostrum; mature milk; processing; preterm; intestinal maturation PRETERM NEONATES HAVE AN IMMATURE intestine that exhibits compromised nutrient absorption, reduced intestinal barrier function, and suboptimal immune responses toward microbes and food antigens (32). Consequently, preterm infants are very sensitive to enteral feeding and more prone to gastrointestinal complications, the most severe one of which is necrotizing enterocolitis (NEC). Early introduction of enteral feeding is beneficial for intestinal maturation and protection against NEC, but the quality of the diet may critically affect these positive effects. For example, the feeding of mother's milk matures the preterm gut and reduces the risk of NEC relative to bovine milk-based infant formula (IF) and possibly also banked donor milk (22,29,34,39,40). Donor milk (DM) is normally obtained at a relatively late stage of lactation, and therefore may not be appropriate as the first diet, when infants are supposed to receive mother's colostrum. Colostrum is the first milk after parturition (1-3 days) and contains trophic factors and immunoregulatory facto...

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Improved growth of preterm infants receiving mother’s own raw milk compared with pasteurized donor milk

Abstract: Mother's own raw milk improves weight gain compared with donor milk in preterm infants. Lactation strategies should be sought that helps mothers to increase their milk production.

Cited by 104 publications

References 31 publications

Early Use of Mother's Own Raw Milk, Maternal Satisfaction, and Breastfeeding Continuation in Hospitalised Neonates: A Prospective Cohort Study

Early Use of Mother's Own Raw Milk, Maternal Satisfaction, and Breastfeeding Continuation in Hospitalised Neonates: A Prospective Cohort Study

Mothers’ views of milk banking: sample of İzmir

Raw bovine milk improves gut responses to feeding relative to infant formula in preterm piglets

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