Improved healing of the deeply incisional wounds in partially scaled common carp by zinc sulphate bath

El‐Adl, Mohamed; Abdelkhalek, Nevien; Mahgoub, Hebatallah A.; Salama, Mohamed; Ali, M.A.

doi:10.1111/are.13805

Cited by 6 publications

(1 citation statement)

References 52 publications

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“…Copper, zinc and methylene blue (MB) are commonly used to eradicate external parasites and fungal diseases in fish; copper and zinc are commonly used as therapeutic agents for protozoan parasites and fixed ciliates, respectively (El‐Adl et al ., 2018; Jezierska et al ., 2009; Owatari et al ., 2020; Tavares‐Dias, 2021; Virgula et al ., 2017). MB is a phenothiazine cationic compound that is often used as an alternative to malachite green to control bacterial, fungal and parasitic infections (Robertson et al ., 2009).…”

Section: Introductionmentioning

confidence: 99%

Toxicity of common biocides used in aquaculture to embryos and larvae of Brachymystax tsinlingensis Li

Guo

Chu

Song

et al. 2023

Journal of Fish Biology

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Brachymystax tsinlingensis Li is a threatened fish species endemic to China. With the problems of environmental factors and seeding breeding diseases, it is important to further improve the efficiency of seeding breeding and the basis of resource protection. This study investigated the acute toxicity of copper, zinc and methylene blue (MB) on hatching, survival, morphology, heart rate (HR) and stress behaviour of B. tsinlingensis. Eggs (diameter: 3.86 ± 0.07 mm, weight: 0.032 ± 0.004 g) of B. tsinlingensis were selected randomly from artificial propagation and developed from eye‐pigmentation‐stage embryos to yolk‐sac stage larvae (length: 12.40 ± 0.02 mm, weight: 0.03 ± 0.001 g) and exposed to different concentrations of Cu, Zn and MB for 144 h in a series of semi‐static toxicity tests. The acute toxicity tests indicated that the 96‐h median lethal concentration (LC50) values of the embryos and larvae were 1.71 and 0.22 mg l−1 for copper and 2.57 and 2.72 mg l−1 for zinc, respectively, whereas the MB LC50 after 144‐h exposure for embryos and larvae were 67.88 and 17.81 mg l−1, respectively. The safe concentrations of copper, zinc and MB were 0.17, 0.77 and 6.79 mg l−1 for embryos and 0.03, 0.03 and 1.78 mg l−1 for larvae, respectively. Copper, zinc and MB treatments with concentrations greater than 1.60, 2.00 and 60.00 mg l−1, respectively, led to a significantly low hatching rate and significantly high embryo mortality (P < 0.05), and copper and MB treatments with concentrations greater than 0.2 and 20 mg l−1 led to significantly high larvae mortality (P < 0.05). Exposure to copper, zinc and MB resulted in developmental defects, including spinal curvature, tail deformity, vascular system anomalies and discolouration. Moreover, copper exposure significantly reduced the HR of larvae (P < 0.05). The embryos exhibited an obvious change in behaviour, converting from the normal behaviour of emerging from the membrane head first to emerging tail first, with probabilities of 34.82%, 14.81% and 49.07% under copper, zinc and MB treatments, respectively. The results demonstrated that the sensitivity of yolk‐sac larvae to copper and MB was significantly higher than that of embryos (P < 0.05) and that B. tsinlingensis embryos or larvae might be more resistant to copper, zinc and MB than other members of the Salmonidae family, which benefits their resource protection and restoration.

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Section: Introductionmentioning

confidence: 99%

Toxicity of common biocides used in aquaculture to embryos and larvae of Brachymystax tsinlingensis Li

Guo

Chu

Song

et al. 2023

Journal of Fish Biology

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Chitosan composite hydrogels cross‐linked by multifunctional diazo resin as antibacterial dressings for improved wound healing

Gao

Zhang

et al. 2020

J Biomedical Materials Res

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Skin lesions and injuries can increase the risk of pathogen infections. Developing efficacious wound dressings could effectively prevent bacterial infection and accelerate wound healing. Herein, we developed chitosan composite hydrogels cross‐linked by multifunctional diazo resin (DR) as antibacterial dressings for improved wound healing. The composite hydrogels were in situ formed by electrostatic interactions, chelation interactions, and covalent bonds between carboxylated chitosan and DR under ultraviolet assisted without small photosensitizer. The resultant hydrogels (noted as DR‐CCH) showed good stability at different DR concentrations in physiological buffers. The antibacterial assays showed the DR‐CCH could inhibit and kill Escherichia coli and Staphylococcus aureus. What is more, our hydrogels could accelerate wound healing in vivo. The present study demonstrates this composite DR‐CCH with trace zinc has potential for accelerated wound healing.

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Dietary Zinc Oxide for Growth and Immune Stimulation of Aquatic Animals Species: A Review

et al. 2023

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Improved healing of the deeply incisional wounds in partially scaled common carp by zinc sulphate bath

Cited by 6 publications

References 52 publications

Toxicity of common biocides used in aquaculture to embryos and larvae of Brachymystax tsinlingensis Li

Toxicity of common biocides used in aquaculture to embryos and larvae of Brachymystax tsinlingensis Li

Chitosan composite hydrogels cross‐linked by multifunctional diazo resin as antibacterial dressings for improved wound healing

Dietary Zinc Oxide for Growth and Immune Stimulation of Aquatic Animals Species: A Review

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