Improved highly accurate localized motion imaging for monitoring high-intensity focused ultrasound therapy

Qu, Xiaolei; Azuma, Takashi; Sugiyama, Ryusuke; Kanazawa, Kengo; Seki, Mika; Sasaki, Akira; Takeuchi, Hideki; Fujiwara, Keiichi; Itani, Kazunori; Tamano, Satoshi; Takagi, Shu; Sakuma, Ichiro; Matsumoto, Yoichiro

doi:10.7567/jjap.55.07kf04

Cited by 10 publications

(9 citation statements)

References 47 publications

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“…However, errors were found in the estimated lesions’ size and overtreatment occurred due to system delay after ceasing the HIFU sonication. Qu et al (2016) improved the LMI method by employing a dynamic cross-correlation window, which decreased the RMSE of the estimated coagulation length to 1.69 mm during porcine liver ablation ( N = 49), but increased processing time for displacement estimation from 2.05 ± 0.05 s to 2.64 ± 0.36 s for 28 A-mode scan lines.…”

Section: Introductionmentioning

confidence: 99%

Real-Time Spatiotemporal Control of High-Intensity Focused Ultrasound Thermal Ablation Using Echo Decorrelation Imaging in ex Vivo Bovine Liver

Abbass

Killin

Mahalingam

et al. 2018

Ultrasound in Medicine & Biology

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The ability to control high-intensity focused ultrasound (HIFU) thermal ablation using echo decorrelation imaging feedback was evaluated in ex vivo bovine liver. Sonications were automatically ceased when the minimum cumulative echo decorrelation within the region of interest exceeded an ablation control threshold, determined from preliminary experiments as -2.7 (log-scaled decorrelation per millisecond), corresponding to 90% specificity for local ablation prediction. Controlled HIFU thermal ablation experiments were compared with uncontrolled experiments employing two, five or nine sonication cycles. Means and standard errors of the lesion width, area and depth, as well as receiver operating characteristic curves testing ablation prediction performance, were computed for each group. Controlled trials exhibited significantly smaller average lesion area, width and treatment time than five-cycle or nine-cycle uncontrolled trials and also had significantly greater prediction capability than two-cycle uncontrolled trials. These results suggest echo decorrelation imaging is an effective approach to real-time HIFU ablation control.

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Section: Introductionmentioning

confidence: 99%

Real-Time Spatiotemporal Control of High-Intensity Focused Ultrasound Thermal Ablation Using Echo Decorrelation Imaging in ex Vivo Bovine Liver

Abbass

Killin

Mahalingam

et al. 2018

Ultrasound in Medicine & Biology

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“…New biomedical applications of this therapeutic method are also being explored, such as hemostasis and gene therapy [4]. Pioneering studies have demonstrated that HIFU, with spatial-peak temporal-average intensities (IsPTa) between 500 and 104 W/cm 2 at the beam focus [5], can produce necrotic lesions in deep-seated tissue through thermal coagulation and cavitation disruption, with minimal damage to the surrounding tissues [6][7][8].…”

Section: Introductionmentioning

confidence: 99%

Design of a High-Power Multilevel Sinusoidal Signal and High-Frequency Excitation Module Based on FPGA for HIFU Systems

et al. 2021

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High-intensity focused ultrasound (HIFU) is a noninvasive therapy that uses focused ultrasound to treat a part of the tissue; high temperatures can damage tissues by heat. HIFU has many applications in the field of surgery and aesthetics and is used increasingly in everyday life. In this article, we discuss the mainboard design that controls the HIFU system with the ability to create a multistep sine wave compatible with many different applications. The signal used to trigger the transducer is a sinusoidal signal with a frequency adjustable from 0.1 to 3 MHz. In addition, the power supplied to the HIFU transducer is also controlled easily by the configuration parameters installed in the control circuit board. The proposed control and design method generates a voltage signal that doubles the supply voltage, thereby reducing the current on the MOSFET. The hardware design is optimized for a surface-mounted device-type MOSFET without the need for an external heat sink. In tests, we conducted a harmonious combination of two output signals to activate the same HIFU probe. The results showed that the energy transferred to the HIFU transducer increased by 1.5 times compared to a single channel. This means that the HIFU treatment time is reduced when using this method, with absolutely no changes in the system structure.

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“…With different contact forces, the absolute threshold of hearing can be affected by more than 10 dB. 20) Unlike other transducers for mechanical systems using ultrasound [19][20][21][22][23][24][25][26][27][28][29][30][31][32] , a bone-conducted transducer is not used with matching layers or with rigid mounts. International standards on bone-conducted sound transducer calibration reflect the effect of contact force on bone-conducted sound.…”

Section: Introductionmentioning

confidence: 99%

Method of estimating contact force of bone-conducted sound transducer with a two-degrees-of-freedom vibrating model

Ogiso

Mizutani

Zempo

et al. 2019

Jpn. J. Appl. Phys.

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In this paper, we propose a method of estimating the contact force of a bone-conducted sound transducer with a two-degrees-of-freedom vibrating model. First, the electrical impedance of the transducer was measured by varying the contact force applied to 12 human subjects. The model was fit to the measurement electrical impedance by changing the damping coefficient. The results showed that the model's damping coefficient is related to the contact force. The fitting was valid when the contact force was below than 3.0 N. Second, a contact force estimation method utilizing the relationship between the damping coefficient and the contact force was proposed. The contact force was estimated by estimating the damping coefficient from the measured impedance and calculating the corresponding contact force from the damping-contact force curve. The estimation results showed that the proposed method achieves reasonable accuracy compared to a previous method using a neural network. Also, the proposed method can be achieved with only two calibration conditions, 0.3 N and 0.5 N, by employing a physical model. This drastically reduces the calibration process compared to the previous methods.

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Improved highly accurate localized motion imaging for monitoring high-intensity focused ultrasound therapy

Cited by 10 publications

References 47 publications

Real-Time Spatiotemporal Control of High-Intensity Focused Ultrasound Thermal Ablation Using Echo Decorrelation Imaging in ex Vivo Bovine Liver

Real-Time Spatiotemporal Control of High-Intensity Focused Ultrasound Thermal Ablation Using Echo Decorrelation Imaging in ex Vivo Bovine Liver

Design of a High-Power Multilevel Sinusoidal Signal and High-Frequency Excitation Module Based on FPGA for HIFU Systems

Method of estimating contact force of bone-conducted sound transducer with a two-degrees-of-freedom vibrating model

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