In horizontal and highly deviated portions of an Extended Reach Drilling (ERD) well, cuttings beds form on the low-side of the annulus. The bed partially blocks the annulus resulting in excessive pressure loss and a higher equivalent circulating density (ECD) that is exacerbated by the increase in length of the annulus. This condition limits hole-cleaning capabilities. As a result, selecting favorable drilling parameters is not always sufficient to overcome the hole cleaning problem. Recently, the use of downhole Mechanical Cleaning Devices (MCDs) has been introduced to the industry to mitigate the problem without inducing excessive ECD. Although the use of these tools is increasing, very limited studies have been conducted to optimize their performance.This paper presents results of an experimental study that was carried out to evaluate cuttings removal efficiency of MCDs and applications of MCDs for optimizing ERD systems. Experiments were carried out in a large-scale flow loop that has an 8-inch transparent test section. Three different drillpipe sizes were considered in the investigation. The Taguchi approach was implemented to reduce the number of experiments while covering the most relevant parameters such as flow rate, ROP, diameter ratio, tool design and drillpipe rotation speed. For each test, the amount of cuttings accumulated in the test section was determined from weight measurements. Results indicate that the tools significantly reduce the amount of cuttings in the annulus, especially around the MCDs, compared to locations where there is no tool.Experimental results were evaluated to obtain the overall effect of operating parameters on annular cuttings concentration and develop correlations. The results show that the flow rate and inclination angle have the most significant impact. The correlations are useful to develop an analytical model for designing and optimizing drilling systems with MCDs, either in terms of operating parameters or drillstring design.