Improved image quality with simultaneously reduced radiation exposure: Knowledge-based iterative model reconstruction algorithms for coronary CT angiography in a clinical setting

André, Florian; Fortner, Philipp; Vembar, Mani; Müeller, Dirk; Stiller, Wolfram; Buss, Sebastian J.; Kauczor, Hans‐Ulrich; Katus, Hugo A.; Korosoglou, Grigorios

doi:10.1016/j.jcct.2017.02.007

Cited by 16 publications

(7 citation statements)

References 16 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…There are a few limitations of this study. First, FBP was not compared with HIR and IMR, although some studies in the literature have reported that HIR can reduce image noise and help obtain images of good quality during CCTA compared with FBP (192425). Second, diagnostic accuracy in the detection of high-risk plaques was not verified using the gold standard.…”

Section: Discussionmentioning

confidence: 99%

Coronary CT Angiography with Knowledge-Based Iterative Model Reconstruction for Assessing Coronary Arteries and Non-Calcified Predominant Plaques

Tang

et al. 2019

Korean J Radiol

View full text Add to dashboard Cite

Objective To assess the effects of iterative model reconstruction (IMR) on image quality for demonstrating non-calcific high-risk plaque characteristics of coronary arteries. Materials and Methods This study included 66 patients (53 men and 13 women; aged 39–76 years; mean age, 55 ± 13 years) having single-vessel disease with predominantly non-calcified plaques evaluated using prospective electrocardiogram-gated 256-slice CT angiography. Paired image sets were created using two types of reconstruction: hybrid iterative reconstruction (HIR) and IMR. Plaque characteristics were compared using the two algorithms. The signal-to-noise ratio (SNR) and contrast-to-noise ratio (CNR) of the images and the CNR between the plaque and adjacent adipose tissue were also compared between the two reformatted methods. Results Seventy-seven predominantly non-calcified plaques were detected. Forty plaques showed napkin-ring sign with the IMR reformatted method, while nineteen plaques demonstrated napkin-ring sign with HIR. There was no statistically significant difference in the presentation of positive remodeling, low attenuation plaque, and spotty calcification between the HIR and IMR reconstructed methods (all p > 0.5); however, there was a statistically significant difference in the ability to discern the napkin-ring sign between the two algorithms (χ 2 = 12.12, p < 0.001). The image noise of IMR was lower than that of HIR (10 ± 2 HU versus 12 ± 2 HU; p < 0.01), and the SNR and CNR of the images and the CNR between plaques and surrounding adipose tissues on IMR were better than those on HIR ( p < 0.01). Conclusion IMR can significantly improve image quality compared with HIR for the demonstration of coronary artery and atherosclerotic plaques using a 256-slice CT.

show abstract

Section: Discussionmentioning

confidence: 99%

Coronary CT Angiography with Knowledge-Based Iterative Model Reconstruction for Assessing Coronary Arteries and Non-Calcified Predominant Plaques

Tang

et al. 2019

Korean J Radiol

View full text Add to dashboard Cite

show abstract

“…For native coronary arteries, André et al. found IMR CR and CS likewise to offer improved image quality in comparison to FBP and HIR images (35).…”

Section: Discussionmentioning

confidence: 99%

Knowledge-based iterative reconstructions for imaging of coronary artery stents: first in-vitro experience and comparison of different radiation dose levels and kernel settings

et al. 2018

View full text Add to dashboard Cite

Background Advanced knowledge-based iterative model reconstructions (IMR) became recently available for routine computed tomography (CT). Using more realistic physical models it promises improved image quality and potential radiation dose reductions, both possibly beneficial for non-invasive assessment of coronary stents. Purpose To evaluate the influence of different IMR settings at different radiation doses on stent lumen visualization in comparison to filtered back projection (FBP) and first-generation (hybrid) iterative reconstruction (HIR). Material and Methods Ten coronary stents in a coronary phantom were examined at four different dose settings (120 kV/125 mAs, 120 kV/75 mAs, 100 kV/125 mAs, 100 kV/75 mAs). Images were reconstructed with stent-specific FBP and HIR kernels and with IMR using CardiacRoutine (CR) and CardiacSharp (CS) settings at three different iteration levels. Image quality was evaluated using established parameters: image noise; in-stent attenuation difference; and visible lumen diameter. Results Image noise was significantly lower in IMR than in corresponding HIR and FBP images. At lower radiation doses, image noise increased significantly except with IMR CR3 and IMR CS3. Visible lumen diameters were significantly larger with IMR CS than with FBP, HIR, and IMR CR. IMR CR showed the smallest attenuation difference, while attenuation was artificially decreased extensively with IMR CS. FBP and HIR showed moderately increased in-stent attenuations. No relevant influence of used radiation doses on visible lumen diameters or attenuation differences was found. Conclusion IMR CR reduces image noise significantly while offering comparable stent-specific image quality in comparison to FBP and HIR and therefore potentially facilitates stent lumen delineation. Utilization of IMR CS for stent evaluation seems unfavorable due to artificial image alterations.

show abstract

“…The iterative algorithm performs iterative reconstruction of the projection data of metal objects according to certain criteria. Compared with the projection interpolation algorithm, it can effectively remove the metal artefacts and correct the image to yield a higher quality 48 . In addition, this study showed that liquid metal gallium is discharged slowly from the body, which seriously affects the body's activity, food consumption, and defecation, and its biological safety is low.…”

Section: Postoperative Observationsmentioning

confidence: 99%

Experimental Analysis of the Utility of Liquid Metal Gallium as a Contrast Agent for CT Hepatic Artery Angiography in Living Rabbits

Liu

Wang

Zhao

et al. 2020

Preprint

View full text Add to dashboard Cite

CT angiography (CTA) technology, as a non-invasive or minimally invasive examination method, is commonly used in the clinic to obtain vascular network images, and iodinated contrast agents play a vital role in it. At present, the second-generation non-ionic contrast agent ioversol are most commonly used in CTA, but its preparation process is complicated, the manufacture technology of it is high, and it is associated with some adverse drug reactions (ADRs), such as allergies and drug toxicity. In this work, based on the low melting point (29.78℃) and low viscosity of liquid metal gallium, it was used for the first time as an angiographic contrast agent for in vivo hepatic artery angiography. According to the statistical analysis of the smallest visible diameter of the hepatic artery and the contrast effect between the blood vessels and their surrounding tissues in CT images, we confirmed that compared with CT imaging using ioversol for hepatic artery angiography, that using liquid metal gallium produced more intuitive and excellent vascular imaging effects.In other words, the use of liquid metal gallium as an angiographic contrast agent has a certain value in living organ angiography. However, the lower overall image quality and higher side-effects of liquid metal gallium in CTA indicate that the use of liquid metal gallium as a contrast agent for living organs still needs to overcome some problems, such as the metallic artefacts and its hypertonicity. Only in this way can liquid metal gallium become a potential contrast agent candidate for angiography in animal experiments and possibly even in the clinical.

show abstract

Improved image quality with simultaneously reduced radiation exposure: Knowledge-based iterative model reconstruction algorithms for coronary CT angiography in a clinical setting

Cited by 16 publications

References 16 publications

Coronary CT Angiography with Knowledge-Based Iterative Model Reconstruction for Assessing Coronary Arteries and Non-Calcified Predominant Plaques

Coronary CT Angiography with Knowledge-Based Iterative Model Reconstruction for Assessing Coronary Arteries and Non-Calcified Predominant Plaques

Knowledge-based iterative reconstructions for imaging of coronary artery stents: first in-vitro experience and comparison of different radiation dose levels and kernel settings

Experimental Analysis of the Utility of Liquid Metal Gallium as a Contrast Agent for CT Hepatic Artery Angiography in Living Rabbits

Contact Info

Product

Resources

About