Improved Insulin Resistance, Adiponectin and Liver Enzymes without Change in Plasma Vaspin Level after 12 Weeks of Exercise Training among Obese Male Adolescents

Abstract

Background: The purpose of this study was to investigate (1) the association among anthropometric measurements, cardiopulmonary fitness, liver enzymes and inflammatory markers including vaspin levels among male adolescents, and (2) the effects of a 12 week aerobic exercise training on insulin resistance, liver enzymes and inflammatory markers including vaspin levels among obese male adolescents were also studied. Methods: We compared anthropometric and metabolic parameters between thirty obese (BMI ≧ 25) and fifteen lean (BMI < 23) male high school students (17.0 ± 0.1 y). Obese male subjects were randomly assigned to either exercise intervention group (OIG, n = 18) or control group (OCG, n = 12). OIG participated in aerobic exercise (5 days/wk) for 12 weeks, while the OCG participated only in regular physical education class. Results: Partial correlation coefficient analysis showed no association between vaspin levels and metabolic parameters including insulin resistance. However, vaspin levels have significantly correlated with intima-media thickness (IMT). Parameters which were significantly associated with insulin resistance were gamma-glutamyltransferase (GGT) and VO2max, while adiponectin levels showed significant association with VO2max and fasting insulin levels. Twelve weeks of exercise training significantly improved insulin resistance with concurrent improvement in adiponectin and GGT without affecting the vaspin levels. Conclusion: Our findings suggest that 12 week of aerobic exercise training significantly improved insulin resistance and metabolic parameters. However, it did not affecting the plasma vaspin levels.

The effects of physical activity on adipokines in individuals with overweight/obesity across the lifespan: A narrative review

“…283 The potential reasons for these discrepancies in these studies could be due to differences in age, BMIs and the cohorts employed. 283 Vaspin response is proposed as a compensatory mechanism to the lower insulin resistance found with obesity. 284 In support, vaspin levels correlate with fasting insulin and homeostasis model assessment of insulin resistance in individuals with obesity and also decreases with PA. 285 These data suggest that vaspin diminishes insulin resistance 285 and that PA lowers vaspin level by decreasing insulin resistance.…”

“…277,281,282 However, a cross-sectional study found no significant differences in vaspin levels between control adolescent male subjects and individuals with obesity (BMI ≥ 25) subjected to 12 weeks of aerobic exercise. 283 However, vaspin levels were significantly associated with intima-media thickness, an early indicator of atherosclerosis. 283 The potential reasons for these discrepancies in these studies could be due to differences in age, BMIs and the cohorts employed.…”

“…283 However, vaspin levels were significantly associated with intima-media thickness, an early indicator of atherosclerosis. 283 The potential reasons for these discrepancies in these studies could be due to differences in age, BMIs and the cohorts employed. 283 Vaspin response is proposed as a compensatory mechanism to the lower insulin resistance found with obesity.…”

Layperson-Led vs Professional-Led Behavioral Interventions for Weight Loss in Pediatric Obesity

“…We initially identified 25 586 citations and, after removing duplicates, we reviewed 20 514 unique citations. Of those, 78 RCTs 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 , 49 , 50 , 51 , 52 , 53 , 54 , 55 , 56 , 57 , 58 , 59 , 60 , 61 , 62 , 63 , 64 , 65 , 66 , 67 , 68 , 69 , 70 , 71 , 72 , 73 , 74 , 75 , 76 , 77 , 78 , 79 , 80 , 81 , 82 , 83 , 84 , 85 , 86 , 87 , 88 , 89 , 90 , 91 , 92 ...…”

“…Details for each individual trial are presented in eTable 3 in the Supplement . The majority of RCTs were performed in children aged 1-12 years (n = 53) 9 , 11 , 32 , 33 , 39 , 40 , 43 , 44 , 45 , 46 , 48 , 49 , 52 , 53 , 54 , 56 , 58 , 59 , 62 , 63 , 64 , 67 , 68 , 69 , 70 , 71 , 73 , 76 , 77 , 80 , 83 , 84 , 85 , 86 , 87 , 88 , 89 , 91 , 92 , 93 , 95 , 99 , 100 , 101 , 102 , 103 , 104 , 107 , 108 , 110 , 111 , 112 , 114 ; 25 were conducted in adolescents aged 13-18 years, 10 , 34 , 35 , 36 , 37 ,…”