Improved Insulin Resistance and Lipid Metabolism by Cinnamon Extract through Activation of Peroxisome Proliferator‐Activated Receptors

Sheng, Xiaoyan; Zhang, Yuebo; Gong, Zhaohui; Huang, Cheng; Zang, Ying

doi:10.1155/2008/581348

Cited by 166 publications

(141 citation statements)

References 25 publications

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“…4 PPARs are ligand-activated nuclear hormone receptors expressed mainly in brown adipose tissue and the liver. Activation of various isoforms lowers levels of plasma triglycerides, elevates levels of HDL-C, and increases insulin sensitivity.…”

Section: Discussionmentioning

confidence: 99%

“…4 In animal studies, aqueous cinnamon extracts have been shown to increase the expression of peroxisome proliferator-activated receptors (PPARs), which are transcriptional factors involved in the regulation of insulin resistance and adipogenesis, resulting in improved lipid and glucose metabolism. 5 Several randomized controlled trials (RCTs) in humans have been conducted to explore cinnamon's efficacy; however, they report conflicting results.…”

Section: Cinna M On Use In T Y Pe 2 Dia Be T Esmentioning

confidence: 99%

See 1 more Smart Citation

Cinnamon Use in Type 2 Diabetes: An Updated Systematic Review and Meta-Analysis

Allen

Schwartzman

Baker

et al. 2013

The Annals of Family Medicine

216

131

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PURPOSE Cinnamon has been studied in randomized controlled trials (RCTs) for its glycemic-lowering effects, but studies have been small and show conflicting results. A prior meta-analysis did not show significant results, but several RCTs have been published since then. We conducted an updated systematic review and meta-analysis of RCTs evaluating cinnamon's effect on glycemia and lipid levels.METHODS MEDLINE, Embase, and Cochrane Central Register of Controlled Trials (CENTRAL) were searched through February 2012. Included RCTs evaluated cinnamon compared with control in patients with type 2 diabetes and reported at least one of the following: glycated hemoglobin (A 1c ), fasting plasma glucose, total cholesterol, low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), or triglycerides. Weighted mean differences (with 95% confidence intervals) for endpoints were calculated using random-effects models. RESULTSIn a meta-analysis of 10 RCTs (n = 543 patients), cinnamon doses of 120 mg/d to 6 g/d for 4 to 18 weeks reduced levels of fasting plasma glucose (-24.59 mg/dL; 95% CI, -40.52 to -8.67 mg/dL), total cholesterol (-15.60 mg/ dL; 95% CI, -29.76 to -1.44 mg/dL), LDL-C (-9.42 mg/dL; 95% CI, -17.21 to -1.63 mg/dL), and triglycerides (-29.59 mg/dL; 95% CI, -48.27 to -10.91 mg/ dL). Cinnamon also increased levels of HDL-C (1.66 mg/dL; 95% CI, 1.09 to 2.24 mg/dL). No significant effect on hemoglobin A 1c levels (-0.16%; 95%, CI -0.39% to 0.02%) was seen. High degrees of heterogeneity were present for all analyses except HDL-C (I 2 ranging from 66.5% to 94.72%). CONCLUSIONSThe consumption of cinnamon is associated with a statistically significant decrease in levels of fasting plasma glucose, total cholesterol, LDL-C, and triglyceride levels, and an increase in HDL-C levels; however, no significant effect on hemoglobin A 1c was found. The high degree of heterogeneity may limit the ability to apply these results to patient care, because the preferred dose and duration of therapy are unclear.

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Section: Discussionmentioning

confidence: 99%

Section: Cinna M On Use In T Y Pe 2 Dia Be T Esmentioning

confidence: 99%

Cinnamon Use in Type 2 Diabetes: An Updated Systematic Review and Meta-Analysis

Allen

Schwartzman

Baker

et al. 2013

The Annals of Family Medicine

216

131

View full text Add to dashboard Cite

show abstract

“…Moreover, cinnamon bark proanthocyanidins prevents the formation of advanced glycation end-products [13]. Cinnamon extract also improves insulin resistance and lipid metabolism by activating peroxisome proliferator-activated receptors (PPARs) [14], and stimulates insulin secretion in pancreatic β-cell line [15]. Nevertheless, there has been no recent literature to evaluate the intestinal α-glucosidase and pancreatic α-amylase inhibitory activities of various cinnamon bark species.…”

Section: Introductionmentioning

confidence: 99%

Inhibitory Activity of Cinnamon Bark Species and their Combination Effect with Acarbose against Intestinal α-glucosidase and Pancreatic α-amylase

Adisakwattana

Lerdsuwankij

Poputtachai

et al. 2011

Plant Foods Hum Nutr

162

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Inhibition of α-glucosidase and pancreatic α-amylase is one of the therapeutic approaches for delaying carbohydrate digestion, resulting in reduced postprandial glucose. The aim of this study was to evaluate the phytochemical analysis and the inhibitory effect of various cinnamon bark species against intestinal α-glucosidase and pancreatic α-amylase. The results showed that the content of total phenolic, flavonoid, and condensed tannin ranged from 0.17 to 0.21 g gallic acid equivalent/g extract, from 48.85 to 65.52 mg quercetin equivalent/g extract, and from 0.12 to 0.15 g catechin equivalent/g extract, respectively. The HPLC fingerprints of each cinnamon species were established. Among cinnamon species, Thai cinnamon extract was the most potent inhibitor against the intestinal maltase with the IC(50) values of 0.58 ± 0.01 mg/ml. The findings also showed that Ceylon cinnamon was the most effective intestinal sucrase and pancreatic α-amylase inhibitor with the IC(50) values of 0.42 ± 0.02 and 1.23 ± 0.02 mg/ml, respectively. In addition, cinnamon extracts produced additive inhibition against intestinal α-glucosidase and pancreatic α-amylase when combined with acarbose. These results suggest that cinnamon bark extracts may be potentially useful for the control of postprandial glucose in diabetic patients through inhibition of intestinal α-glucosidase and pancreatic α-amylase.

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“…The mechanisms of interaction between the components of dietary supplements and oral anti-diabetic agents have not been explicitly described in the literature. The possible mechanisms of hypoglycemic action have been summarized for many dietary supplements, which makes it possible to hypothesize that drug-dietary supplement interaction may indeed occur [11][12][13][14]. In this study, almost half the T2DM patients took dietary supplements, which could indicate a high potential risk of interactions with drugs or nutrients.…”

Section: Discussionmentioning

confidence: 84%

Dietary Supplementation During Diabetes Therapy and the Potential Risk of Interactions

Zabłocka‐Słowińska¹,

Dzielska²,

Gryszkin³

et al. 2014

Adv Clin Exp Med

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Background. The classification of dietary supplements as foodstuffs promotes widespread access to them and increases the possibility of patients using them without being monitored. Unreasonable or excessive consumption of these preparations poses risks to type-2 diabetes mellitus (T2DM) patients (among others) because it may induce disturbances in glycemic control. The aim of this study was to assess the frequency of dietary supplementation among patients using anti-diabetic drugs and such patients' nutrient intake in order to evaluate the potential risk of interactions. Material and Methods. The study participants were 150 diabetic patients who were asked about the type of pharmacotherapy and dietary supplementation they used. The intake of minerals, vitamins, dietary fiber and long-chain polyunsaturated fatty acids (LC-PUFAs) from the patients' diets were also assessed, using the 24-h dietary recall method. Results. The highest percentage of patients taking individual anti-diabetic drugs used supplements containing magnesium and herbs. They also often took antioxidant vitamins, B-group vitamins and omega-3 fatty acids. In the majority of patients (both those using supplements and those not), the dietary recall showed insufficient intake of potassium, calcium and magnesium, as well as of vitamin E, folic acid, vitamin D and LC-PUFAs. In addition, their diets provided high median amounts of iron, copper, vitamin A and β-carotene. Conclusions. The level of dietary supplementation and the ill-balanced diets reported by the majority of the recruited T2DM patients indicate a high possible risk of interactions with the anti-diabetic drugs. Therefore, patients should always consult their physicians regarding dietary supplementation, and medically trained staff should routinely assess dietary intake to avoid hazardous changes in the activity of drugs (Adv Clin Exp Med 2014, 23, 6, 939-946).

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Improved Insulin Resistance and Lipid Metabolism by Cinnamon Extract through Activation of Peroxisome Proliferator‐Activated Receptors

Cited by 166 publications

References 25 publications

Cinnamon Use in Type 2 Diabetes: An Updated Systematic Review and Meta-Analysis

Cinnamon Use in Type 2 Diabetes: An Updated Systematic Review and Meta-Analysis

Inhibitory Activity of Cinnamon Bark Species and their Combination Effect with Acarbose against Intestinal α-glucosidase and Pancreatic α-amylase

Dietary Supplementation During Diabetes Therapy and the Potential Risk of Interactions

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