Deformation is one important failure mode of turbine blades. e quality of a model seriously influences the reliability optimization of turbine blades in turbo machines. To improve the reliability optimization of turbine blades, this paper proposes a novel machine learning-based reliability optimization approach, named improved support vector regression (SR) model (ISRM) method, by fusing artificial bee colony (ABC), traditional SR model, and multipopulation genetic algorithm (MPGA). In this proposed method, the ABC algorithm was applied to find the optimal parameters in the SR model to establish accurate ISRM, following the thought of the surrogate model method and the randomness of constraints. en the reliability optimization model and procedure with the ISRM method were resolved by the MPGA. Regarding many design parameters (i.e., rotor speed, temperature, and aerodynamic pressure), design objective (i.e., blade deformation), and the randomness constraints of reliability degree and boundary conditions, we performed the reliability optimization of a turbine blade deformation. From the optimization results, we find that the turbine blade deformation is reduced by 0.09329 mm, and the ISRM learning method can improve the reliability optimization design of complex structures with the emphasis on modeling precision and optimization efficiency. e works of this paper provide a machine learning-based reliability optimization approach for the reliability optimization of complex structures and enrich and develop mechanical reliability theory and methods.