Improved large-scale synthesis and characterization of small and medium generation PAMAM dendrimers

Ficker, Mario; Paolucci, Valentina; Christensen, Jørn B.

doi:10.1139/cjc-2017-0108

Cited by 28 publications

(30 citation statements)

References 35 publications

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“…The main challenge relies on preserving their purity and monodispersity upon up-scaled manufacture. Technical details with respect to improved reaction conditions and purification of half-and full-generation PAMAM dendrimers to overcome the critical limitations for upscaling this class of polymers are available elsewhere (Ficker et al, 2017).…”

Section: Dendrimersmentioning

confidence: 99%

Nanoscale Drug Delivery Systems: From Medicine to Agriculture

Vega-Vásquez

Mosier

Irudayaraj

2020

Front. Bioeng. Biotechnol.

210

107

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The main challenges in drug delivery systems are to protect, transport and release biologically active compounds at the right time in a safe and reproducible manner, usually at a specific target site. In the past, drug nano-carriers have contributed to the development of precision medicine and to a lesser extent have focused on its inroads in agriculture. The concept of engineered nano-carriers may be a promising route to address confounding challenges in agriculture that could perhaps lead to an increase in crop production while reducing the environmental impact associated with crop protection and food production. The main objective of this review is to contrast the advantages and disadvantages of different types of nanoparticles and nano-carriers currently used in the biomedical field along with their fabrication methods to discuss the potential use of these technologies at a larger scale in agriculture. Here we explain what is the problem that nano-delivery systems intent to solve as a technological platform and describe the benefits this technology has brought to medicine. Also here we highlight the potential drawbacks that this technology may face during its translation to agricultural applications, based on the lessons learned so far from its use for biomedical purposes. We discuss not only the characteristics of an ideal nano-delivery system, but also the potential constraints regarding the fabrication including technical, environmental, and legal aspects. A key motivation is to evaluate the potential use of these systems in agriculture, especially in the area of plant breeding, growth promotion, disease control, and post-harvest quality control. Further, we highlight the importance of a rational design of nano-carriers and identify current research gaps to enable scale-up relevant to applications in the treatment of plant diseases, controlled release of fertilizers, and plant breeding.

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Section: Dendrimersmentioning

confidence: 99%

Nanoscale Drug Delivery Systems: From Medicine to Agriculture

Vega-Vásquez

Mosier

Irudayaraj

2020

Front. Bioeng. Biotechnol.

210

107

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“…To date, none of these systems has been used for multicargo delivery in the clinical setting, clearly illustrating the need for further research on their bioactivity and safety. [82c] Considering that these systems have become relatively easy to scale‐up, with emerging production techniques, such as ethanol injection, use of vertical stirred tank reactors, and micellar electrospray, showing narrow size distribution, good reproducibility, and appropriate stability, in the years to come, advancements in chemistry and functionalization are expected to address cytotoxicity and adequate cargo‐loading/protection issues, bridging in that way the gap between proof of concept and clinical translation.…”

Section: Self‐assembly Technologiesmentioning

confidence: 99%

Advancements and Challenges in Multidomain Multicargo Delivery Vehicles

2018

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Reparative and regenerative processes are well-orchestrated temporal and spatial events that are governed by multiple cells, molecules, signaling pathways, and interactions thereof. Yet again, currently available implantable devices fail largely to recapitulate nature's complexity and sophistication in this regard. Herein, success stories and challenges in the field of layer-by-layer, composite, self-assembly, and core-shell technologies are discussed for the development of multidomain/multicargo delivery vehicles.

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“…It has furthermore a natural handle for attachment of a linker (the piperazine moiety) that should have minimal effect on the antimicrobial properties. A G0 DAB-core PAMAMdendrimer [38] ( Figure 2) was chosen as a compromise between multivalency, solubility of the conjugate and a wish to keep the molecular weight as low as possible. The molecular design is shown in Figure 3 and involves the covalent attachment of Ciprofloxacin via a linker to a small PAMAM-dendrimer.…”

Section: Resultsmentioning

confidence: 99%

Synthesis and Antimicrobial Properties of a Ciprofloxacin and PAMAM-dendrimer Conjugate

et al. 2020

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Infections caused by bacteria resistant to antibiotics are an increasing problem. Multivalent antibiotics could be a solution. In the present study, a covalent conjugate between Ciprofloxacin and a G0-PAMAM dendrimer has been synthesized and tested against clinically relevant Gram-positive and Gram-negative bacteria. The conjugate has antimicrobial activity and there is a positive dendritic effect compared to Ciprofloxacin itself.

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Improved large-scale synthesis and characterization of small and medium generation PAMAM dendrimers

Cited by 28 publications

References 35 publications

Nanoscale Drug Delivery Systems: From Medicine to Agriculture

Nanoscale Drug Delivery Systems: From Medicine to Agriculture

Advancements and Challenges in Multidomain Multicargo Delivery Vehicles

Synthesis and Antimicrobial Properties of a Ciprofloxacin and PAMAM-dendrimer Conjugate

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