2013
DOI: 10.1002/ptr.5011
|View full text |Cite
|
Sign up to set email alerts
|

Improved Lipid Profile in Hyperlipidemic Patients Taking Vaccinium arctostaphylos Fruit Hydroalcoholic Extract: A Randomized Double‐Blind Placebo‐Controlled Clinical Trial

Abstract: Dyslipidemia is a common contributory cause of cardiovascular disease. Vaccinium arctostaphylos L. (Caucasian whortleberry) fruit is rich of anthocyanins. Anthocyanins may exert cardioprotective effects by various mechanisms such as favorably modulating dyslipidemia. Therefore, in this randomized double-blind placebo-controlled clinical trial with hyperlipidemic (hypercholesterolemic and/or hypertriglyceridemic) patients aged 20-60 years, the effects of taking a standardized whortleberry fruit hydroalcoholic e… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
2
1

Citation Types

0
62
0
10

Year Published

2014
2014
2022
2022

Publication Types

Select...
8

Relationship

0
8

Authors

Journals

citations
Cited by 56 publications
(72 citation statements)
references
References 24 publications
0
62
0
10
Order By: Relevance
“…Berries and their constituent polyphenolic compounds have been shown to exert lipid-lowering effects in adults with CVD risk factors. Some of these findings can be summarized as follows: 1) they increase HDL cholesterol (25)(26)(27)(28)(29); 2) they lower total and/or LDL cholesterol (13,14,(27)(28)(29)(30); and 3) they have no effect on TGs in most of these reported clinical studies. Conversely, studies also reported no effects of berry polyphenols on serum lipid profiles in adults with the metabolic syndrome or other CVD risks (15,17,(31)(32)(33).…”
Section: Discussionmentioning
confidence: 91%
“…Berries and their constituent polyphenolic compounds have been shown to exert lipid-lowering effects in adults with CVD risk factors. Some of these findings can be summarized as follows: 1) they increase HDL cholesterol (25)(26)(27)(28)(29); 2) they lower total and/or LDL cholesterol (13,14,(27)(28)(29)(30); and 3) they have no effect on TGs in most of these reported clinical studies. Conversely, studies also reported no effects of berry polyphenols on serum lipid profiles in adults with the metabolic syndrome or other CVD risks (15,17,(31)(32)(33).…”
Section: Discussionmentioning
confidence: 91%
“…None of the six trials carried out ITT analysis. Among them, the dropout rates for 3 trails ranged from 2.2% to 7.41%, while one trail was 23.81%, which may affect the estimation[21]. The other five trials have almost equal number of dropout from each intervention group.…”
Section: Resultsmentioning
confidence: 99%
“…Meta-regression with age, BMI, dose of anthocyanin supplementation, intervention duration, sample size, baseline concentration of serum lipids, and country showed no significant impact on between-study heterogeneity (P>0.05). The leave-one-out analysis showed that the key contributor to this high heterogeneity was one study conducted by Kianbakht et al[21]. After excluding it, the heterogeneity was reduced to I 2 = 70% for TC, I 2 = 0% for LDL-C, and I 2 = 41% for HDL-C.…”
Section: Resultsmentioning
confidence: 99%
See 1 more Smart Citation
“…Besides grapes, other berries such as strawberry, acai ( Euterpe oleracea Mart. ), Caucasian whortleberry ( Vaccinium arctostaphylos L.), sea buckthorn, and bilberry also have a potent lipid-lowering effect [113,114,115,116,117,118,119,120,121]. The benefits of berries on the serum lipid metabolism might contribute to anthocyanin.…”
Section: Clinical Trialsmentioning
confidence: 99%