“…The most critical feature of solid-phase synthesis is the attachment of substrate to the polymeric resin (Scott, 2009), so the first anchoring unit should be loaded efficiently with polystyrene support and the linkage should be stable enough to tolerate the subsequent chemical transformations and chemical environment. Trityl linker is commonly used in solidphase peptide synthesis which allows the "protected" compound to be subjected to various chemical manipulations and consequently to afford pure compounds without numerous purification steps (Park et al, 2004;Olsen et al, 2004;Lundquist et al, 2006;Crestey et al, 2008). Additionally, the trityl linker is readily cleaved under mild acidic condition (1% TFA in dichloromethane) owing to the high stability of trityl cations (Rothman et al, 2003).…”